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Vesicular rash in a newborn
2 Department of Dermatology, Venereology, Hospital S. João, EPE; Faculty of Medicine, Oporto University, Portugal
3 Department of Pathology, Hospital S. João, EPE, Portugal
Correspondence Address:
A Nogueira
Department of Dermatology and Venereology, Hospital S. João, EPE, Alameda Prof. Hernâni Monteiro, 4200 - 319 Porto
Portugal
How to cite this article: Nogueira A, Lisboa C, Eloy C, Mota A, Azevedo F. Vesicular rash in a newborn. Indian J Dermatol Venereol Leprol 2009;75:330 |
A full-term female newborn, with no history of consanguinity in the parents, presented at birth with generalized vesicles, pustules and blisters, appearing in crops, with preferential distribution on the limbs. She was otherwise well and was afebrile. A herpetic infection was considered, so after taking swabs, she was started on intravenous acyclovir. After an initial good response, the dermatosis worsened, assuming a roughly linear pattern [Figure - 1] and manifested with an impressive blood eosinophilia. The infectious cause was excluded (Tzanck test showed no giant cells, and there was a negative PCR for HSV, VZV and bacteriologic examination), and a skin biopsy was performed, which revealed spongiotic intraepidermal vesicles with a rich eosinophil infiltrate [Figure - 2]. Her mother recalled a history of a similar rash in her infancy, and displayed faint linear hypopigmented streaks on her calves, which were better observed with the Wood′s lamp [Figure - 3], conical incisor teeth and vertex alopecia.
What is your Diagnosis ?
1. |
Ehrenreich M, Tarlow MM, Godlwska-Janusz E, Schwartz RA. Incontinentia pigmenti (Bloch Sulzberger Syndrome): A systemic disorder. Cutis 2007;79:355-62.
[Google Scholar]
|
2. |
Berlin AL, Paller AS, Chan LW. Incontinentia pigmenti: A review and update on the molecular basis of pathophysiology. J Am Acad Dermatol 2002;47:169-87.
[Google Scholar]
|
3. |
Nelson DL. NEMO, NFkB signaling and incontinentia pigmenti. Cur Op Gen Develop 2006;16:282-8.
[Google Scholar]
|
4. |
Stitt W, Scott G, Caserta M, Goldsmith L. Coexistence of incontinentia pigmenti and neonatal herpes simplex infection. Pediatr Dermatol 1998;15:112-5.
[Google Scholar]
|
5. |
Aradhya S, Woffendin H, Jakins T, Bardaro T, Esposito T, Smahi A, et al . A recurrent deletion in the ubiquitously expressed NEMO (IKK-g) gene accounts for the vast majority of incontinentia pigmenti mutations. Hum Mol Genet 2001;10:2171-9.
[Google Scholar]
|
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