Antifungal activity of allylamines against agents of eumycetoma

Abstract

The antifungal activity of the two allylamines naftifine and terbinafine was investigated against 22 strains of eumycetes isolated from cases of eumycetoma by agar dilution. The isolates included Madurella mycetomatis (4), M. Grisea (8), Pyrenochaeta romeroi (2), Exophiala jeanselmei (2) and Leptosphaeria tompkinsii (1) from black grain eumycetomas and Pseudalescheria boydii (3) Acremonium kiliense (1) and A. recifei (1) form pale grain eumycetomas. Terbinafine was more active than naftifine inhibiting 50% (MIC50) and 90% (MIC90) of the black grain eumycetoma agents at 0.5 and 2.5 ?g/ml respectively. The MIC50s and MIC90s of naftifine were 1 and 5 ?g/ml. For pale grain eumycetoma agents, the MIC range for terbinafine and naftifine were ??0.01 - 100 and 0.1 - 100 ?g/ml.