Evaluation of Furacin - S (nitrofurazone and Hydrocortisone Acetate) in the Treatment of Different Dermatoses

Abstract

Nitrofurazone (Furacin) is well known for its antibacterial activity. Its topical application although quite effective, is often alleged to be associated with local irritation and sensitization. Hence a new product 'Furacin-s' incorporating hydrocortisone 1%, in Furacin, is tested in a clinical trial in impetigo, folliculitis, pompholyx, eczematoid, and seborrhoeic dermatitis with 3 other preparations, (Framycetin sulphate + Dexamethasone acetate -0.1% and Neomycin, Bacitracin, Polymyxin B sulf + Hydrocortisone 1% in a control study. A total of 190 cases divided into variable of number was studied. Results showed Furacin-s to be more effective and acceptable for treating impetigo and folliculitis. Pompholyx lesions with possible microbic background responded very satisfactory, the product gave comparatively poor result in cases of seborrhoeic and eczematoid dermatitis. No side effect was observed with Furacin-s. A routine bacteriological culture done in all the cases of and folliculitis showed that coagulase-positive staph aureus was the major pathogen in both these conditions.