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B-cell chronic lymphocytic leukemia with bilateral ear involvement
Corresponding author: Dr. Alberto Andamoyo Castañeda, Plaza Hospital Civil, 29009 Málaga, Spain. alberto.andamoyo.castaneda@gmail.com
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Received: ,
Accepted: ,
How to cite this article: Andamoyo-Castañeda A, Godoy-Díaz DJ, Ayala-Blanca M. B-cell chronic lymphocytic leukemia with bilateral ear involvement. Indian J Dermatol Venereol Leprol 2022;88:562-3.
A 66-year-old woman, presented with multiple, painless, plum-colored nodules in both ears for the past year, associated with partial destruction of the auricular cartilage [Figures 1a and b]. The histopathologic examination revealed a monomorphic lymphocyte infiltrate which expressed CD5, CD20, CD23, CD43 and was negative for CD3, CD10, cyclin D1, Bcl2 and Bcl6. The findings were compatible with B-cell chronic lymphocytic leukemia (CLL-B). The myelogram done showed a lymphocyte clone with a similar immunohistochemical profile. Pan-body CT-scan and blood tests were normal. This patient responded well to a local radiation therapy (total dose of 16 Gy) with resolution of the nodules. In the literature, bilateral ear involvement as an initial presentation of CLL-B, mimicking a red rosary or cauliflower, is exceptional, but characteristic.1,2
- Right ear. Plum-colored nodules with partial destruction of the auricular cartilage
- Left ear. Multiple erythematous to violaceous nodules
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent.
Financial support and sponsorship
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Conflicts of interest
There are no conflicts of interest.
References
- Leukemia cutis in a patient with chronic lymphocytic leukemia presenting as bilateral helical nodules. SAGE Open Med Case Rep. 2016;4:1-5.
- [CrossRef] [PubMed] [Google Scholar]
- Bilateral cauliflower ear as the presenting sign of B-cell chronic lymphocytic leukemia. J Cutan Pathol. 2014;41:73-7.
- [CrossRef] [PubMed] [Google Scholar]
