Generic selectors
Exact matches only
Search in title
Search in content
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Special Article
Specialty Interface
Studies
Study Letter
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Systematic Reviews and Meta-analysis
Tables
Technology
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
View Point
Viewpoint
What’s new in Dermatology
View/Download PDF

Translate this page into:

Case Letters
87 (
1
); 64-66
doi:
10.25259/IJDVL_112_20

A case series and literature review of erythema palmare hereditarium (Lane’s disease)

Department of Dermatology, School of Medicine, Marmara University, Istanbul, Turkey
Corresponding author: Dr. Meryem Aktas, Marmara University, Istanbul, Turkey Marmara University Pendik Education and Research Hospital, Department of Dermatology Fevzi Cakmak , Muhsin Yazicioglu Street. No: 10 34899 Pendik, Istanbul, Turkey. meryemaktas72@gmail.com
Licence
This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

How to cite this article: Özer EC, Demir G, Aktas M, Salman A. A case series and literature review of erythema palmare hereditarium (Lane’s disease). Indian J Dermatol Venereol Leprol 2021;87:64-6.

Sir,

Erythema palmare hereditarium, also known as Lane’s disease, is characterized by an early-onset palmar erythema in the absence of any underlying causes1 We believe that an increased awareness of this rarely-reported, or possibly under-recognized, entity is important to assure the patients and their families regarding the benign nature of erythema palmare hereditarium. Herein, we report two unrelated families with erythema palmare hereditarium and review the previously published data.

An 18-year-old lady presented with asymptomatic palmar erythema which was present since her childhood. Dermatological examination showed diffuse bilateral palmar erythema without any scaling [Figure 1a]. Family history revealed that her father had similar lesions on both palms as long as he could remember [Figure 1b].Telangiectasias on a homogenous pink background were noticed on dermoscopic examination [Figure 1c].

Figure 1a:: Diffuse palmar erythema and telangiectasias
Figure 1b:: Mild erythema and telangiectasias on her father’s palms
Figure 1c:: Telangiectasias on a homogenous pink background on dermoscopy (Heine Delta 20, non-polarized dermoscope, ×10)

A 5-year-old girl presented with asymptomatic palmar redness. The lesions were first noticed shortly after her birth. The dermatological examination was normal except for the ill-defined erythematous patches on palms [Figure 2a]. Similar lesions were also evident on bilateral palms of her elder brother [Figure 2b]. Dermoscopic examination revealed homogenous pink-red areas [Figure 2c].

Figure 2a:: Ill-defined erythema on palms
Figure 2b:: Erythematous patches on the palms of her elder brother
Figure 2c:: Telangiectasias on dermoscopy (Heine Delta 20, non-polarized dermoscope, ×10)

The other possible causes of palmar erythema, including pregnancy, liver dysfunction, connective tissue diseases and medications were excluded through a detailed history, physical examination and laboratory tests. The lesions were not associated with any physical stimuli such as changes in temperature. Therefore, a diagnosis of erythema palmare hereditarium were made based on the clinical, laboratory findings and positive family history in all patients. Palmar erythema may occur as a primary/physiologic condition or may be a cutaneous manifestation of hepatic, endocrine, autoimmune, infectious diseases or neoplasms. Primary or physiologic palmar erythema can be classified as idiopathic, pregnancy-related and hereditary, the latter being the most common form of primary palmar erythema among children.2

Erythema palmare hereditarium was first described in two adult patients presenting with diffuse palmar erythema without any underlying cause by Lane in 1929.3 We found only 17 patients who have been reported with this condition since then in literature.1,4-12 We think that the paucity of the reports in literature might be attributed to under-recognition, rather than the rarity of the condition. Females were more commonly affected than males, with 11 of 17 patients reported in the literature being female. All patients had positive family history and very early-onset palmar erythema. Recessive or dominant transmissions have been suggested. However, the exact mode of inheritance has not been elucidated yet. The increased recognition of this condition may lead to diagnosis of more patients and help the elucidation of the underlying genetic defect, if any. The clinical characteristics of previously reported patients with erythema palmare hereditarium are given in Table 1.

Table 1:: Summary of the reported patients in the literature
Reference Number of patients Female/male Family history (n) Involvement Symptoms
Lane, 1929 2 0/2 2/2 Bilateral palmar None
Meirowsky, 1933 1 0/1 2 Bilateral palmar, thenar and hypothenar eminences None
Walsh, 1941 2 2/0 1/1 Bilateral palmar erythema None
Dorn, 1958 1 1/0 1/1 Palmar erythema None
Rupec, 2000 1 1/0 4 Bilateral palmar, thenar and hypothenar eminences None
Sarma and Wang, 2007 1 0/1 2 Bilateral palmar None
Kluger, 2010 1 1/0 1 Bilateral palmar monticule, thenar and hypothenar eminences, phalanges None
Langanauer, 2014 1 1/0 0 Bilateral palmar, hypothenar eminences None
Duriex, 2016 1 1/0 2 Bilateral palmar, thenar and hypothenar eminences, the palmar aspect of fingers None
Gurioli, 2017 5 3/2 1/1/0/1/1 Bilateral palmar, thenar and hypothenar eminences None
de lorenzi, 2019 1 1/0 2 Bilateral palmar erythema with telangiectasia to the thenar and hypothenar eminences None
Present report 4 2/2 1/1/1/1 Bilateral palmar erythema None

n: Number of patients

The diagnosis of erythema palmare hereditarium requires a positive family history, onset shortly after birth or during childhood and exclusion of any systemic disease through a careful history and physical examination.1,11

The dermoscopic features of erythema palmare hereditarium have been previously defined in only one study.11 A dermoscopic pattern consisting of arborizing vessels on a red, structureless background, similar to observation in our patients, was reported to be suggestive of erythema palmare hereditarium. Future studies might help to understand if the use of dermoscopy in the diagnosis of erythema palmare hereditarium is of benefit.

In conclusion, erythema palmare hereditarium is an innocuous, familial form of palmar erythema and should be kept in mind in patients with early-onset palmar erythema without any underlying cause. Considering the comprehensive list of differential diagnosis of secondary palmar erythema, increased recognition of this entity among physicians seems important to prevent patients from undergoing excessive laboratory testing which might cause anxiety in patients.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form, the patient has given her consent for her images and other clinical information to be reported in the journal. The patient understand that name and initials will not be published and due efforts will be made to conceal identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

References

  1. , . Erythema palmare hereditarium (Lane's red palms): A forgotten entity? J Am Acad Dermatol. 2010;63:e46.
    [CrossRef] [PubMed] [Google Scholar]
  2. , , . Palmar erythema. Am J Clin Dermatol. 2007;8:347-56.
    [CrossRef] [PubMed] [Google Scholar]
  3. . Erythema Palmare Hereditarum (Red palms) Arch Dermatol. 1929;20:445.
    [CrossRef] [Google Scholar]
  4. . Über das Krankheitsbild des Erythema palmo-plantare symmetricum hereditarium. Arch Dermatol Syph. 1933;168:420-8.
    [CrossRef] [Google Scholar]
  5. , . Erythema palmare and naevus-araneus-like telangiectases. Arch Dermatol. 1941;44:616.
    [CrossRef] [Google Scholar]
  6. , , . Unregelmäßig dominanter Erbgang bei Erythema palmare et plantare (Lane) Z Haut Geschl Kr. 1958;25:141-5.
    [Google Scholar]
  7. , , , . Erythema palmare hereditarium ("red palms") Hautarzt. 2000;51:264-5.
    [CrossRef] [PubMed] [Google Scholar]
  8. , . Erythema Palmare hereditarium (red palms): Lane's disease. Dermatol Online J. 2007;13:28.
    [Google Scholar]
  9. . Erythema palmare hereditarium ('Red Palms', 'Lane's Disease') Case Rep Dermatol. 2014;6:245-7.
    [CrossRef] [PubMed] [Google Scholar]
  10. , , , . Erythema palmare hereditarium (Lane's disease): Report of a paediatric case. Ann Dermatol Venereol. 2016;143:32-5.
    [CrossRef] [PubMed] [Google Scholar]
  11. , , , . Lane's disease (Erythema Palmare Hereditarium): A report of five cases and a review of the literature. Pediatr Dermatol. 2017;34:590-4.
    [CrossRef] [PubMed] [Google Scholar]
  12. , . Erythema palmare hereditarum. Presse Med. 2019;48:582-3.
    [CrossRef] [PubMed] [Google Scholar]

Fulltext Views
1,218

PDF downloads
758
View/Download PDF
Download Citations
BibTeX
RIS
Show Sections