Generic selectors
Exact matches only
Search in title
Search in content
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obervation Letter
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Special Article
Specialty Interface
Studies
Study Letter
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Tables
Technology
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
View Point
Viewpoint
What’s new in Dermatology
View/Download PDF
Net Study
2008:74:3;298-298
doi: 10.4103/0378-6323.41402

Acne neonatorum in the eastern Saudi Arabia

Omar M Alakloby1 , Iqbal A Bukhari1 , Bassam Hassan Awary2 , Khalid Mohammed Al-Wunais1
1 Department of Dermatology, College of Medicine, King Faisal University, Dammam, Saudi Arabia
2 Department of Pediatrics, College of Medicine, King Faisal University, Dammam, Saudi Arabia

Correspondence Address:
Iqbal A Bukhari
King Fahad Hospital of the University, P.O. Box 40189, Alkhobar 31952
Saudi Arabia
How to cite this article:
Alakloby OM, Bukhari IA, Awary BH, Al-Wunais KM. Acne neonatorum in the eastern Saudi Arabia. Indian J Dermatol Venereol Leprol 2008;74:298
Copyright: (C)2008 Indian Journal of Dermatology, Venereology, and Leprology

Abstract

Background: Acne neonatorum (AN) is characterized by a facial eruption of inflammatory and noninflammatory acne lesions in a neonate. Hyperactivity of sebaceous glands, stimulated by neonatal androgens, is implicated in its pathogenesis. Aim: To elucidate the clinical profile of AN in eastern Saudi Arabia. Methods: All patients diagnosed with AN in King Fahd Hospital of the University in Khobar, Saudi Arabia, during the year 2005 were evaluated clinically. Results: AN was diagnosed in 26 patients (male/female ratio 1:1). The lesions included mainly facial comedones (30.8%); papules and pustules (15.3% each); and combination of papules, pustules, and cysts (53.4%). Conclusion: All patients recovered spontaneously. In 50% of the cases, one of the parents reported having had acne vulgaris during adolescence. Hereditary factors seem to play a significant role in our series.
Keywords: Acne neonatorum, Infantile acne

Introduction

Acne neonatorum (AN) is not an uncommon pediatric dermatological condition and usually appears during the neonatal period. It has been estimated that up to 20% of newborns may be affected with this condition. [1] Clinically, the patients present with facial eruption of inflammatory and noninflammatory acne lesions. AN runs a short and self-limited course. [2] The aim of this study was to elucidate the clinical profile of AN in eastern Saudi Arabia.

Methods

This was a prospective study conducted at the outpatient department (OPD) of King Fahd Hospital of the University (KFHU) in Al-Khobar, Saudi Arabia, during the year 2005. The diagnosis of AN was made on clinical grounds alone. All patients were evaluated in detail including a physical examination, with the emphasis being on evaluating the number and type of lesions and the sites of involvement. A standardized questionnaire was given to the parents, that sought information on parents′ acne history, such as age at onset, sex of the parent, and duration of the disease; history of the present pregnancy and delivery, with special emphasis on history of any drug intake during pregnancy or delivery was also taken.

Results

Twenty six neonates with AN were identified during the study period. There were 13 (50%) males and 13 (50%) females. The mean age at onset was 1.19 weeks. In 13 (50%) cases, one of the parents had a positive history of acne vulgaris in adolescence or early adulthood. All pregnancies and deliveries were with no reported complications, except for one case where the mother had had hypertension during pregnancy. Clinical examination of the neonates revealed the presence of different types of lesions: 8 (30.8%) patients had comedones only; 4 (15.3%) had papules and pustules [Figure - 1]; and 14 (53.4%) had a combination of papules, pustules, and cysts. The sites of involvement were the forehead, cheeks, and chin; two of these were affected in 9 (34.6%) neonates while 13 (50%) patients had more than two areas affected and 4 (15.3%) had only a single area affected. The duration of the disease was less than 1 month in all the patients; the lesions did not tend to persist beyond this period. None of the patients received any anti-acne medical treatment, but daily cleansing with water and soap was advised for all of them.

Discussion

AN is a condition that is usually mild and transient, thus making it liable to be underreported. [1] It is mentioned that male neonates with this condition outnumber females [1],[3] but this trend was not seen in our series. Lesions of AN are primarily closed comedones, but open comedones as well as inflammatory lesions, such as papules and pustules, may also be observed. [4] Cysts and nodules are rare and may even lead to scarring in an occasional neonate. [5] The face is usually affected, specifically the cheeks or the forehead. [1],[3] Lesions most commonly appear during the first 2-4 weeks of life and spontaneously resolve within a couple of months. [4],[6] Classically, infantile acne starts after the third month of life. It seems difficult to draw a demarcation line between neonatal and infantile acne, since some cases of neonatal acne may persist beyond the neonatal period and these then share features with infantile acne and may even be considered infantile acne. [4],[6],[7],[8],[9],[10],[11],[12],[13],[14]

The etiopathogenesis is unknown, but several factors may contribute to AN. These include genetic factors - which is supported by the positive family history in our study - and an intrinsic hormonal effect due to the production of 3-hydroxysteroids by hyperactive adrenal glands. [1],[3] Some male infants, from birth until 6-12 months of life, produce pubertal levels of luteinizing hormone and even testosterone, [3],[15] which may be responsible for the male predominance seen in some studies. [1],[3],[16] The hormonal role is evident from other forms of acne as well, eg, steroid acne, premenstrual acne, and menopausal acne. [17] The correlation between familial hyperandrogenism and AN has been shown. [18] The role of Malassezia furfur in neonatal pustulosis has been suggested as a contributing factor for the development of AN. [19],[20]

Our results showed a male: female ratio of 1:1 in contrast to previous studies, which found a male predominance. [1],[3],[7],[8] Most lesions were mainly on the face, with only a few extrafacial lesions. Morphologically, they were primarily papules, pustules, and cysts, similar to the study of Katsambas et al . [8]

The differential diagnosis of AN includes: infectious diseases of bacterial, viral, or fungal etiology; erythema toxicum neonatorum; neonatal sebaceous gland hyperplasia; acne infantum; acne venenata infantum; and acneiform reactions to drugs such as lithium or phenytoin. [1],[12],[19],[20],[21] Recalcitrant or severe disease requires investigation for adrenal cortical hyperplasia, presence of a virilizing tumor, or underlying endocrinopathy. [3],[4],[7],[22]

Usually, no treatment is needed as spontaneous recovery is the rule, as was seen in most of our cases. [4],[6] However, cases that persist beyond the neonatal period are categorized and treated as infantile acne. [23] The principle of the treatment of these cases is the same as for acne vulgaris. For mild cases, topical treatment like benzoyl peroxide, erythromycin, and retinoids are recommended. Oral erythromycin, 125 mg twice daily, is recommended for moderate cases. [1],[3],[7] Severe cases or erythromycin-resistant patients can be given isotretinoin in a dose of 0.2-1.5 mg/kg/day for 5-14 months. [7],[24],[25] Close monitoring is mandatory to avoid the serious side effects of isotretinoin.

References
1.
Jansen T, Burgdorf WHC, Plewig G. Pathogenesis and treatment of acne in childhood. Pediatr Dermatol 1997;14:17-21.
[Google Scholar]
2.
Yonkovsky DM, Pochi PE. Acne vulgaris in childhood: Pathogenesis and management. Pediatr Dermatol 1986;4:127-36.
[Google Scholar]
3.
Lucky AW. A review of infantile and pediatric acne. Dermatology 1998;196:95-7.
[Google Scholar]
4.
Kaminer MS, Gilchrest BA. The many faces of acne. J Am Acad Dermatol 1995;32:S6-14.
[Google Scholar]
5.
Giknis FL, Hall WK, Tolman MM. Acne neonatorum. Arch Dermatol Syph 1952;66:717-21.
[Google Scholar]
6.
Duke EM. Infantile acne associated with transient increases in plasma concentration of luteinizing hormone, follicle-stimulating hormone and testosterone. Br Med J 1981:282:1275-8.
[Google Scholar]
7.
Cunliffe WJ, Baron SS, Coulson IH. Clinical and Therapeutic Study of 29 Patients with Infantile Acne. Br J Dermatol 2002;145:463-6.
[Google Scholar]
8.
Katsambas A, Katoulis A, Stavropoulos P. Acne neonatorum: A study of 22 cases. Int J Dermatol 1999;38:128-30.
[Google Scholar]
9.
Janniger CK. Neonatal and infantile acne vulgaris. Cutis 1993;52:16.
[Google Scholar]
10.
Sigurdsson V, De Wit RF, De Groot AC. Infantile acne. Br J Dermatol 1991;125:285.
[Google Scholar]
11.
Stankler L, Campbell AG. Neonatal acne vulgaris: A possible feature of fetal hydantoin syndrome. Br J Dermatol 1980;103:453-5.
[Google Scholar]
12.
Chew EW, Bingham A, Burrows D. Incidence of acne vulgartis in patients with infantile acne. Clin Exp Dermatol 1990;15:376-7.
[Google Scholar]
13.
Dupont C. A study of juvenile acne. Clin Exp Dermatol 1989;12:175-6.
[Google Scholar]
14.
Herane MI, Ando I. Acne in infancy and acne genetics. Dermatology 2003;206:24-8.
[Google Scholar]
15.
Forest MG, Cathiard AM, Bertrand JA. Evidence of testicular activity in early infancy. J Clin Endocrinol Metab 1973;37:148-51.
[Google Scholar]
16.
Van Praag MCG, Rooij RW, Folkers E, Spritzer R, Menke HE, Oranje AP. Diagnosis and treatment of pustular disorders in the neonate. Pediatr Dermatol 1997;14:131-43.
[Google Scholar]
17.
Bergler-Czo PB, Bizezinska-WcisLo L. Hormonal factors in etiology of common acne. Pol Merkur Lekarski 2004;16:490-2.
[Google Scholar]
18.
Bekaert C, Song M, Delvigne A. Acne neonatorum and familial hyperandrogenism. Dermatology 1998;196:453-4.
[Google Scholar]
19.
Rapelanoro R, Mortureux P, Couprie B, Maleville J, Taοeb A. Neonatal malassezia fur-fur pustulosis. Arch Dermatol 1996;132:190-3.
[Google Scholar]
20.
Bernier V, Weill FX, Hirigoyen V, Elleau C, Feyler A, Labrθze C, et al. Skin colonization by an Malasseria species in neonates: A prospective study in relationship with neonatal cephalic pustulosis. Arch Dermatol 2002;138:215-8.
[Google Scholar]
21.
Wagner A. Distinguishing vesicular and pustular disorders in the neonate. Curr Opin Pediatr 1997;9:396-405.
[Google Scholar]
22.
De Raeva L, De Schepper J, Smitz J. Prepubertal acne: A cutaneous marker of androgen excess. J Am Acad Dermatol 1995;32:181-4.
[Google Scholar]
23.
Odom RB, James WD, Berger TG. Andrew's Diseases of the Skin: Clinical Dermatology. 9 th Ed, Philadelphia: WB Saunders; 2000. p. 295.
th Ed, Philadelphia: WB Saunders; 2000. p. 295.'>[Google Scholar]
24.
Torrelo A, Pastor MA, Zambrano A. Severe Acne Infantum Successfully Treated with Isotretinoin. Pediatr Dermatol 2005;22:357-9.
[Google Scholar]
25.
Barnes CJ, Eichenfield LF, Lee J, Cunningham BB. A practical approach for the use of oral isotretinoin for infantile acne. Pediatr Dermatol 2005;22:166-9.
[Google Scholar]

Fulltext Views
101

PDF downloads
67
Show Sections