Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current Issue
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Images
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Reviewers 2022
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Snippets
Special Article
Specialty Interface
Studies
Study Letter
Study Letters
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Systematic Review and Meta-Analysis
Systematic Reviews and Meta-analyses
Systematic Reviews and Meta-analysis
Tables
Technology
Therapeutic Guideline-IADVL
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
Therapy Letters
View Point
Viewpoint
What’s new in Dermatology
Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current Issue
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Images
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Reviewers 2022
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Snippets
Special Article
Specialty Interface
Studies
Study Letter
Study Letters
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Systematic Review and Meta-Analysis
Systematic Reviews and Meta-analyses
Systematic Reviews and Meta-analysis
Tables
Technology
Therapeutic Guideline-IADVL
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
Therapy Letters
View Point
Viewpoint
What’s new in Dermatology
View/Download PDF

Translate this page into:

Letter to the Editor - Therapy Letter
2019:85:3;326-329
doi: 10.4103/ijdvl.IJDVL_225_18
PMID: 30860163

Aggressive erosive lichen planus associated with hepatitis C responding to sofosbuvir/ledipasvir treatment

Daniel Morgado-Carrasco, Andrea Combalia, Xavier Fustà-Novell, José Manuel Mascaró Jr, Pilar Iranzo
 Department of Dermatology, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain

Correspondence Address:
Pilar Iranzo
Department of Dermatology, Hospital Clínic de Barcelona, Universitat de Barcelona, Calle Villarroel 170, Barcelona 08036
Spain
How to cite this article:
Morgado-Carrasco D, Combalia A, Fustà-Novell X, Mascaró Jr JM, Iranzo P. Aggressive erosive lichen planus associated with hepatitis C responding to sofosbuvir/ledipasvir treatment. Indian J Dermatol Venereol Leprol 2019;85:326-329
Copyright: (C)2019 Indian Journal of Dermatology, Venereology, and Leprology

Sir,

Hepatitis C virus infection can induce several extrahepatic manifestations including dermatologic conditions such as lichen planus, porphyria cutanea tarda and cryoglobulinemia.[1] Here we present a patient with chronic hepatitis C virus infection who developed an aggressive form of lichen planus and achieved clinical resolution after therapy with direct-acting antivirals.

A woman in her 80s presented with painful ulcers in her mouth, legs, feet and genitalia [Figure - 1]a of 8 weeks duration. Severe paronychia with erosions leading to loss of her first, second and third toenails was also observed since 4 weeks [Figure - 1]b. She had well-controlled type 2 diabetes mellitus with chronic renal failure and was on insulin glargine therapy. The patient also suffered from chronic hepatitis C virus infection which she developed secondary to a transfusion performed 60 years previously. Histologic examination of a punch biopsy from the ulcer on the right foot showed acanthosis with hyperkeratosis, hypergranulosis, saw-tooth appearance and subepidermal clefting. A band-like inflammatory infiltrate and vacuolar basal layer degeneration was observed in the superficial dermis. Direct immunofluorescence examination revealed shaggy linear basement membrane deposition of fibrinogen and abundant colloid bodies in the papillary dermis (IgM) [Figure - 2]. These findings ruled out an autoimmune blistering disease and inflammatory dermatoses such as parakeratosis pustulosa, acrodermatitis continua of Hallopeau and necrolytic acral erythema. On the basis of the clinical and pathological features, a diagnosis of erosive lichen planus was made. Considering the co-existing diabetes and chronic renal failure, oral corticosteroids or cyclosporine were not prescribed and the patient was also reluctant to take hydroxychloroquine. Though mycophenolate mofetil tablets were initiated in a dose of 500 mg twice daily with mild clinical response, it had to be discontinued subsequently due to pancytopenia. Laboratory work-up revealed transaminitis (γ-glutamyl transpeptidase 233 U/L, aspartate aminotransferase 53 U/L; reference value 5–40 U/L), reactive hepatitis C virus antibodies and a hepatitis C virus viral load of 1,053,000 copies/mL. Hepatitis C virus genotype was 1b. Serologies ruled out hepatitis B viral infection and HIV. Zinc levels were not measured as the patient did not seem to be at increased risk for nutritional deficiency (alcoholism, poor diet, malabsorptive disorders or malignancies). As we suspected that the hepatitis C viral infection was contributing to aggressive course of her disease, the patient was sent to Hepatology Department, where hepatic cirrhosis was confirmed by ultrasonography. Direct-acting antiviral therapy with sofosbuvir 90 mg/day and ledipasvir 400 mg/day for 24 weeks was initiated. No treatment with oral or topical corticosteroids or immunosuppressants was given at this point. Four weeks later, transaminases had normalized and she had an undetectable viral load and cutaneous and mucosal lesions started to heal. There was complete resolution of the cutaneous, oral and genital mucosal erosions in the following 2 months [Figure - 3]. The patient remained asymptomatic, maintained an undetectable viral load and achieved sustained virological response 24 weeks (SVR24) after completion of antiviral therapy. Hepatitis C virus infection was declared cured and the patient has been asymptomatic with no mucocutaneous lesions at 12 months follow-up after direct-acting antiviral withdrawal.

Figure 1:
Figure 2:
Figure 3: Resolution of cutaneous erosions in feet after treatment of hepatitis C viral infection with sofosbuvir/ledipasvir

Studies have shown that introduction of direct-acting antiviral agents has dramatically improved the management of hepatitis C virus infection with sustained virologic response in more than 90% of cases.[2],[3]

The etiology of lichen planus is not fully understood. Lichen planus is an autoimmune disease that can affect the oral and genital mucosa, skin, scalp and nails. Hepatitis C virus-associated lichen planus tends to be chronic and is characterized by a higher prevalence of erosive-ulcerative lesions and poorer treatment outcomes compared to idiopathic lichen planus.[1]

Another dermatosis that has been associated with hepatitis C virus infection is necrolytic acral erythema, and is a differential diagnosis to consider in this scenario. Necrolytic acral erythema is characterized by erythematous plaques and papules most commonly affecting the dorsal aspect of the feet and hands. It also occurs on the shins. Necrolytic acral erythema does not affect the nail bed, nail plate or mucous membranes.[4],[5],[6] Our patient presented with lesions on mucous membranes (oral, genital and anal), cutaneous lesions on the legs and severe nail involvement. Furthermore, histologic findings reported in necrolytic acral erythema are epidermal pallor, necrotic keratinocytes and pigment incontinence, among others[4],[6] while the histologic findings and direct immunofluorescence findings from our patient were highly consistent with lichen planus.

Improvement of skin disorders associated with hepatitis C virus after successful treatment with direct-acting antiviral has been recently reported. Nagao et al. described a series of seven patients diagnosed with oral lichen planus treated with daclatasvir/asunaprevir with complete clinical resolution in four patients and improvement in the other three [Table - 1].[7] In addition, two patients (one case with cutaneous lichen planus and another with erosive oral lichen planus) who had complete resolution of their cutaneous or oral lesions after direct-acting antiviral therapy have recently been described.[8],[9] However, there is also a report of a 55-year-old male with hepatitis C virus and a 30-year history of oral lichen planus developing widespread cutaneous lichen planus lesions following treatment with ledipasvir/sofosbuvir though the treatment had cured the Hepatitis C.[10] To date, there are no reported cases of patients with severe nail lichen planus and hepatitis C virus healing with direct-acting antiviral agents.

Table 1: Summary of patients with chronic hepatitis C virus infection and resolution or improvement of lichen planus after direct acting antiviral therapy

Other dermatoses associated with hepatitis C virus have also benefited from direct-acting antiviral therapy: remission of porphyria cutanea tarda secondary to hepatitis C virus infection was observed in 16 patients after treatment with direct-acting antiviral agents.[11] In a study of 35 patients with symptomatic cryoglobulinemia where 23 of them presented as cutaneous purpura, more than 90% achieved clinical remission after treatment with different combinations of direct-acting antiviral agents.[2]

Multiple studies have reported an association between diabetes mellitus and lichen planus,[12] although it is not well established if poor glycemic control can lead to a more aggressive course of lichen planus.[13] In our case, it is unlikely that diabetes mellitus had played a role in the aggressive course of lichen planus, since the patient presented with good glycemic control.

We have presented a case where a direct-acting antiviral regime, with no concomitant use of corticosteroids or immunosuppressants, has cured an aggressive cutaneous variant of lichen planus. Direct-acting antivirals are safe and highly effective against hepatitis C virus infection and could lead to remission of hepatitis C virus-associated dermatologic conditions. Lichen planus is a common dermatosis; we recommend screening for hepatitis C virus in all cases of severe or refractory lichen planus and initiating treatment with direct-acting antiviral agents in patients with associated hepatitis C virus infection.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form, the patient has given her consent for her images and other clinical information to be reported in the journal. The patient understands that name and initial will not be published and due efforts will be made to conceal identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

References
1.
Garcovich S, Garcovich M, Capizzi R, Gasbarrini A, Zocco MA. Cutaneous manifestations of hepatitis C in the era of new antiviral agents. World J Hepatol 2015;7:2740-8.
[Google Scholar]
2.
Bonacci M, Lens S, Londoño MC, Mariño Z, Cid MC, Ramos-Casals M, et al. Virologic, clinical, and immune response outcomes of patients with hepatitis C virus-associated cryoglobulinemia treated with direct-acting antivirals. Clin Gastroenterol Hepatol 2017;15:575-830.
[Google Scholar]
3.
Tamori A, Enomoto M, Kawada N. Recent advances in antiviral therapy for chronic hepatitis C. Mediators Inflamm 2016;2016. Article ID: 6841628.
[Google Scholar]
4.
Nofal AA, Nofal E, Attwa E, El-Assar O, Assaf M. Necrolytic acral erythema: A variant of necrolytic migratory erythema or a distinct entity? Int J Dermatol 2005;44:916-21.
[Google Scholar]
5.
Patel U, Loyd A, Patel R, Meehan S, Kundu R. Necrolytic acral erythema. Dermatol Online J 2010;16:15.
[Google Scholar]
6.
Abdallah MA, Ghozzi MY, Monib HA, Hafez AM, Hiatt KM, Smoller BR, et al. Necrolytic acral erythema: A cutaneous sign of hepatitis C virus infection. J Am Acad Dermatol 2005;53:247-51.
[Google Scholar]
7.
Nagao Y, Kimura K, Kawahigashi Y, Sata M. Successful treatment of hepatitis C virus-associated oral lichen planus by interferon-free therapy with direct-acting antivirals. Clin Transl Gastroenterol 2016;7:e179.
[Google Scholar]
8.
Yoshikawa A, Terashita K, Morikawa K, Matsuda S, Yamamura T, Sarashina K, et al. Interferon-free therapy with sofosbuvir plus ribavirin for successful treatment of genotype 2 hepatitis C virus with lichen planus: A case report. Clin J Gastroenterol 2017;10:270-3.
[Google Scholar]
9.
Ansari U, Henderson LI, Stott G, Parr K. Treatment with ledipasvir-sofosbuvir for hepatitis C resulting in improvement of lichen planus. JAAD Case Rep 2017;3:67-9.
[Google Scholar]
10.
Scott GD, Rieger KE. New-onset cutaneous lichen planus following therapy for hepatitis C with ledipasvir-sofosbuvir. J Cutan Pathol 2016;43:408-9.
[Google Scholar]
11.
Combalia A, To-Figueras J, Laguno M, Martínez-Rebollar M, Aguilera P. Direct-acting antivirals for hepatitis C virus induce a rapid clinical and biochemical remission of porphyria cutanea tarda. Br J Dermatol 2017;177:e183-4.
[Google Scholar]
12.
Mozaffari HR, Sharifi R, Sadeghi M. Prevalence of oral lichen planus in diabetes mellitus: A meta-analysis study. Acta Inform Med 2016;24:390-3.
[Google Scholar]
13.
Romero MA, Seoane J, Varela-Centelles P, Diz-Dios P, Garcia-Pola MJ. Prevalence of diabetes mellitus amongst oral lichen planus patients. Clinical and pathological characteristics. Med Oral 2002;7:121-9.
[Google Scholar]

Fulltext Views
2,219

PDF downloads
1,169
Show Sections