Generic selectors
Exact matches only
Search in title
Search in content
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Retraction
Review
Review Article
Review Articles
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Special Article
Specialty Interface
Studies
Study Letter
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Tables
Technology
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
View Point
Viewpoint
What’s new in Dermatology
View/Download PDF
Letter to the Editor
2014:80:5;475-476
doi: 10.4103/0378-6323.140331
PMID: 25201861

Annular elastolytic giant cell granuloma treated with topical pimecrolimus

Enzo Errichetti1 , Giuseppe Stinco1 , Claudio Avellini2 , Pasquale Patrone1
1 Department of Experimental and Clinical Medicine, Institute of Dermatology, University of Udine, Udine, Italy
2 Department of Laboratory Medicine, Institute of Pathological Anatomy, University Hospital of Santa Maria della Misericordia, Udine, Italy

Correspondence Address:
Giuseppe Stinco
Department of Experimental and Clinical Medicine, Institute of Dermatology, University of Udine, Ospedale "San Michele", Piazza Rodolone 1, 33013 Gemona del Friuli, Udine
Italy
How to cite this article:
Errichetti E, Stinco G, Avellini C, Patrone P. Annular elastolytic giant cell granuloma treated with topical pimecrolimus. Indian J Dermatol Venereol Leprol 2014;80:475-476
Copyright: (C)2014 Indian Journal of Dermatology, Venereology, and Leprology

Sir,

Annular elastolytic giant cell granuloma is a rare granulomatous skin disease characterized by loss of elastic fibers along with elastophagocytosis by multinucleated giant cells. It clinically presents as small papules which evolve into annular and serpiginous plaques that have slightly raised borders. The centre of the plaque may show hypopigmentation or atrophic changes or both. These are found most commonly over the sun-exposed areas but can be seen over sun-protected areas as well. The other clinical variants include a pure papular form with absence of centrifugal annular lesions and those with reticular, brown to livid, partly atrophic skin lesions. [1],[2] The etiopathogenesis of this condition is not clear. It is thought that ultraviolet radiation, heat or other unknown factors transform the antigenicity of the elastic fibers thus inducing a cellular immune response. [3] The condition usually follows a chronic course, although cases of spontaneous remission have been described. The treatment remains a challenge and several therapeutic modalities have been tried. These include topical, intralesional and systemic steroids, clofazimine, cryotherapy, dapsone, cyclosporine A, methotrexate, psoralen plus ultraviolet A therapy, narrowband ultraviolet B therapy, retinoids, fumaric acid esters, antimalarials, topical calcineurin inhibitors and tranilast alone or in combination with pimecrolimus. [1],[2],[3],[4],[5] We report a case of annular elastolytic giant cell granuloma successfully treated with topical pimecrolimus.

A 63-year-old man with complained of two gradually increasing mildly itchy, annular plaques over the right parietal and occipital scalp for 4 months. The lesion over the parietal scalp appeared first and measured 11 cm in diameter while the other appeared a month later and was 4 cm wide. On examination, these annular plaques had slightly raised, brownish, serpiginous borders and a hypopigmented atrophic center [Figure - 1]a and b. There were no other skin or mucosal lesions. Skin biopsy revealed a non-palisading granulomatous infiltrate in the upper dermis with many multinucleated giant cells and signs of elastophagocytosis [Figure - 2]a and b. Van Gieson special staining revealed loss of elastic fibers in the areas of granulomatous infiltrate [Figure - 2]c. On the basis of clinical and histopathological data, a diagnosis of annular elastolytic giant cell granuloma was made. The patient was treated with pimecrolimus 1% cream twice daily. The lesions resolved with residual atrophy after 3 weeks after which we stopped therapy [Figure - 1]c and d. There was no recurrence at follow up two months later.

Figure 1: Sharply demarcated annular plaques with slightly raised, brownish, serpiginous borders and hypopigmented, atrophic center localized over the, (a) occipital and, (b) right parietal areas of the scalp at the first visit and, (c and d) after 3 weeks of therapy with topical pimecrolimus
Figure 2: (a) Non palisading granulomatous infi ltrate composed predominantly of multinucleated giant cells located in upper reticular dermis (H and E, ×40), (b) magnified view of multinucleated giant cells with signs of elastophagocytosis (H and E, ×200), (c) loss of elastic fibers in the areas of granulomatous infiltrates (Van Gieson staining, ×40)

The treatment of annular elastolytic giant cell granuloma is empirical as there is no standard therapy for this chronic disorder. Limited areas of involvement are treated topically, usually with corticosteroids. However prolonged treatment with topical steroids is not always effective and leads to cutaneous atrophy, a finding often already present in this condition. [1] Other topical therapies include the calcineurin inhibitors tacrolimus and pimecrolimus. [1],[3] However, the efficacy of pimecrolimus has been demonstrated only in association with oral tranilast, an anti-allergic drug which may directly affect the activity of cells of the monocyte macrophage line. [3] The mechanism by which calcineurin inhibitors work in this condition is not clear. Several hypotheses have been proposed which include reduction in the number of lesional CD4+ T-cells, decreased production of cytokines such as interleukin-4, interleukin-13, macrophage colony stimulating factor and γ-interferon, and inhibition of the cellular immune reaction inducing granulomas around elastic fibers. [1],[3]

Although we cannot exclude a spontaneous regression of disease, the significant clinical improvement observed in our case shortly after starting topical pimecrolimus suggests the efficacy of this drug and indicates its possible use as monotherapy. Further studies and reports are needed to confirm these assumptions.

References
1.
Rongioletti F, Baldari M, Burlando M, Parodi A. Papular elastolytic giant cell granuloma: Report of a case associated with monoclonal gammopathy and responsive to topical tacrolimus. Clin Exp Dermatol 2010;35:145-8.
[Google Scholar]
2.
Can B, Kavala M, Türkoðlu Z, Zindancý I, Topaloðlu F, Zemheri E. Successful treatment of annular elastolytic giant cell granuloma with hydroxychloroquine. Int J Dermatol 2013;52:509-11.
[Google Scholar]
3.
Lee HW, Lee MW, Choi JH, Moon KC, Koh JK. Annular elastolytic giant cell granuloma in an infant: Improvement after treatment with oral tranilast and topical pimecrolimus. J Am Acad Dermatol 2005;535 Suppl 1:S244-6.
[Google Scholar]
4.
Espiñeira-Carmona MJ, Arias-Santiago S, Aneiros-Fernández J, Fernández-Pugnaire MA, Naranjo-Sintes R, Aneiros-Cachaza J. Annular erythematous papules in the neckline. Dermatol Online J 2011;17:7.
[Google Scholar]
5.
Babuna G, Buyukbabani N, Yazganoglu KD, Baykal C. Effective treatment with hydroxychloroquine in a case of annular elastolytic giant cell granuloma. Indian J Dermatol Venereol Leprol 2011;77:110-1.
[Google Scholar]

Fulltext Views
127

PDF downloads
37
Show Sections