Antibiotic Insensitivity and Treatment Failure in Gonorrhoea

Abstract

By way of introduction a brief review of the, relevant literature is made in respect of the studies of the sensitivity both in vitro and in vivo of gonococci to antibiotics and of the evolution of the different treatment schedules in treatment of gonorrhoea. A study of case records of 157 patients suffering from acute of gonorrhoca is made as to the effect of penicillin and a few other antibiotics. The case records of 35 PAM treatment failure cases are studied with reference to certain factors such as age, marital status, duration of illness, and previous treatment. 22.3% of patients treated with 0.6 mega PAM proved to be treatment failures. The teenagers have greater chances of escaping resistant gonorrhoea. Duration of illness is longer in more number of TR failure cases than in the successful. Previous attacks of gonorrheoa did not affect the incidence of TR failure. In vitro studies of sensitivity would have been highly useful to choose the dosage and the preparation of the antibiotic and the course of treatment. Penicillin failure is a real problem to be reckoned with but is easily surmountable as the insensitive strains are still susceptible to other antibiotics. Chloramphenicol has been found to effect a clinical cure satisfactorily in the penicillin failure cases.