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Letter in Response to Previous Publication
89 (
); 77-78

Authors’ reply

Department of Dermatology, Bankura Sammilani Medical College, Bankura, India
Department of Pharmacology, Rampurhat Government Medical College, Rampurhat, Birbhum, India
Department of Dermatology, Medical College, Kolkata, West Bengal, India
Department of Dermatology, Sree Narayana Institute of Medical Sciences, Ernakulam, Kerala, India
Belle Vue Clinic, Kolkata, West Bengal, India
Consultant Epidemiologist, Mumbai, Maharashtra, India
Department of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Department of Dermatology, All India Institute of Medical Sciences, New Delhi, India
Department of Pharmacology, Institute of Postgraduate Medical Education and Research, Kolkata, West Bengal, India
Corresponding author: Prof. Nilay Kanti Das, Department of Dermatology, Bankura Sammilani Medical College, Bankura, West Bengal, India.
This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, transform, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

How to cite this article: Patra AC, Sil A, Ahmed SS, Rahaman S, Mondal N, Roy S, et al. Authors’ reply. Indian J Dermatol Venereol Leprol 2023;89:77-8.


We thank the readers of our article1 for going through it in detail and for including it in a journal club discussion.2

The primary conclusions of our study were:

  • Our study established the effectiveness and safety of topical timolol treatment for early (less than eight weeks old) pyogenic granuloma lesions.

  • The drug has a definite role in reducing size and bleeding tendency, although complete resolution is less likely with six weeks of treatment.

  • Timolol, therefore, seems a potential alternative to surgical treatment for pyogenic granulomas. Timolol’s role as an alternative to surgery needs to be further explored in forthcoming studies. Perhaps it could be tried as an adjunct, used before surgery, to shrink lesions and reduce bleeding during the same.

Our pointwise response to the correspondents’ queries and comments:

  1. “In the methodology, the assessment of bleeding tendency which is graded from grade I (excellent) to grade V (no change) should have been mentioned as an assessment of improvement in the bleeding tendency.”2

    Ans: The global assessment of bleeding tendency was done both by the patients and physicians with the help of the 5-point Likert scale. Likert scale was expressed as grade 1- excellent, grade 2- very good, grade 3- good, grade 4- poor and grade 5- no change. This self-explanatory scale assesses control of the bleeding from no change to excellent control.

  2. “Under the ‘Results’ section, the authors claimed that most of the pyogenic granuloma patients were males and were from rural areas. However, the clinicodemographic data tabulated [Table 1] is contradictory and depicts most patients of pyogenic granuloma to be females and from urban areas.”2

    Ans: We stand corrected; most patients were urban females. We thank our readers for minutely scrutinising both the tables and results. However, we must clarify that this change in baseline clinicodemographic detail does not alter our data analysis, results and conclusion in even the slightest manner, as this is just a satellite data.

  3. “There seems to be a disparity in the sizes of images: Figure 2b appears to be of a higher magnification than Figure 2a. Also, the size of pyogenic granuloma in Figure 3b appears to be bigger than Figure 3a. Thus, clinical images are not uniform.”2

    Ans: The size of the lesion in Figure 2b is definitely larger than Figure 2a and this fact is well-appreciated in the post-treatment figure, which shows a new bulge appearing on the left side of the existing lesion. In this case, placebo was used and there was an increase in the size of the lesion, which is documented in the Figure 2b. The colour change of the granuloma is apparent in Figure 3b, which is darker than Figure 3a. Thus, the purpose of the Figures 3a and 3b to demonstrate colour change is served.

  4. “We would also like to bring to your notice that in the section on “Discussion,” it is quoted that four patients had no improvement in the study done by Gupta et al.,3 whereas the original article by Gupta et al. has stated that there was no response in three patients.”2

    Ans: In the study by Gupta et al.,3 the abstract states that there was no response in three patients. However, if we follow the patient characteristics given in Table 1 of the same article, it is documented that patient no. 9, who was suffering from multiple lesions on the scalp, had no response in medium-to-large lesions, taking the count of no response to four patients. This instance has highlighted the importance of reading the full text of any article.

We hope we have clarified certain issues that our readers have had and thank them for their diligent reading. In the same breath, we also find that none of their concerns have any bearing on our results and conclusion. Since the article was criticised in a journal club, we also humbly ask the readers to go beyond reading the abstract of the referenced articles and make it a practice to go through the full articles. We also note, with due humility, the fact that there were no critical comments regarding the methodology, study design and statistical analysis of our study. We hope that our readers will include topical 0.5% timolol in the management of pyogenic granuloma, going by the evidence provided in our article.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.


  1. , , , , , , et al. Effectiveness and safety of 0.5% timolol solution in the treatment of pyogenic granuloma: A randomized, double-blind and placebo-controlled study. Indian J Dermatol Venereol Leprol. 2022;88:500-8.
    [CrossRef] [PubMed] [Google Scholar]
  2. , , , , . Letter to the editor regarding “Effectiveness and safety of 0.5% timolol solution in the treatment of pyogenic granuloma: A randomised, double-blind and placebo-controlled study”. Indian J Dermatol Venereol Leprol. 2023;89:76.
    [Google Scholar]
  3. , , . Is timolol an effective treatment for pyogenic granuloma? Int J Dermotol. 2016;55:592-5.
    [CrossRef] [PubMed] [Google Scholar]

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