Barrier Function Test : Laboratory Evaluation of Tthe Protective Function of Some Barrier Creams Against Cashewnut Shell Oil
S J Pasricha
|How to cite this article:
Pasricha S J. Barrier Function Test : Laboratory Evaluation of Tthe Protective Function of Some Barrier Creams Against Cashewnut Shell Oil. Indian J Dermatol Venereol Leprol 1991;57:132-134
AbstractA barrier function test has been designed to screen the protective capacity of a cream against the cauterizing effect of cashew nut shell oil (CNSO) on the skin. The test consists of applying the barrier cream on a 5 cm circular area of skin on the back of a human volunteer and then at its center applying a 1 cm sq Whatman no. 3 paper disc soaked in the CNSO for 15 minutes and looking for the evidence of cauterization reaction after 48 hours. Of the various creams containing a variety of paraffins, bees wax, polyethylene glycols, methyl cellulose gel, and petrolatum, only polythelene glycol (PER) cream was found to afford adequate protection against cashew nut shell oil. Addition of 10% zinc oxide or 10% kaolin to the PEG cream did not seem to afford any additional protection. Castor oil already being used by the workers was found to be inferior to the PEG cream.