Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current Issue
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
Images in Dermatology
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Media and news
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Images
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Reviewers 2022
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Snippets
Special Article
Specialty Interface
Studies
Study Letter
Study Letters
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Systematic Review and Meta-Analysis
Systematic Reviews and Meta-analyses
Systematic Reviews and Meta-analysis
Tables
Technology
Therapeutic Guideline-IADVL
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
Therapy Letters
View Point
Viewpoint
What’s new in Dermatology
Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current Issue
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
Images in Dermatology
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Media and news
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Images
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Reviewers 2022
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Snippets
Special Article
Specialty Interface
Studies
Study Letter
Study Letters
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Systematic Review and Meta-Analysis
Systematic Reviews and Meta-analyses
Systematic Reviews and Meta-analysis
Tables
Technology
Therapeutic Guideline-IADVL
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
Therapy Letters
View Point
Viewpoint
What’s new in Dermatology
View/Download PDF

Translate this page into:

Letter to the Editor
2009:75:5;535-537
doi: 10.4103/0378-6323.55420
PMID: 19736454

Bilateral pilomatricomas of the brow region in a female

Fatemeh Shafikhani, Sarah Hashemzadeh, Arash Ayoubi
 Department of dermatology of Imam Khomeini hospital, Jondi Shapur medical university of Ahwaz, Iran

Correspondence Address:
Fatemeh Shafikhani
Department of dermatology of Imam Khomeini hospital, Jondi Shapur medical university of Ahwaz
Iran
How to cite this article:
Shafikhani F, Hashemzadeh S, Ayoubi A. Bilateral pilomatricomas of the brow region in a female. Indian J Dermatol Venereol Leprol 2009;75:535-537
Copyright: (C)2009 Indian Journal of Dermatology, Venereology, and Leprology

Sir,

Here, we report a case of bilateral pilomatricoma of the brow region. We believe that this case is unique because of the bilateral involvement of this area. Multiple pilomatricomas are rare and are mostly associated with other conditions. [1],[2],[3],[4] This case did not have any associations.

The patient is a 20-year-old female who presented with bilateral nodules of the brows since the last 1 year. The right nodule was 1.5 x 1 cm and the left nodule was 1 x 1 cm in size [Figure - 1]. They were firm on consistency but were mobile on the underlying structures. The overlying skin was normal in appearance. Her family history for the same condition was negative. She did not report any other disorder or any history of trauma. Routine laboratory tests were normal. The clinical differential diagnosis included epidermal cysts, pilar cysts and pilomatricomas. Fine needle aspiration was performed but no aspirate was achieved. Total excision of one of the nodules was performed. Histopathologic evaluation revealed irregularly shaped islands of epithelial cells. Two types of cells, basophilic cells and shadow cells, comprised the islands [Figure - 2]. Thus, the diagnosis of pilomatricoma was confirmed. Excision of the other nodule showed the same changes. Pilomatricomas arise from the hair follicle matrix cells. This tumor makes up around 20% of all hair follicle-related tumors. The majority of the patients are under 20 years of age, and females are affected more often than males. [1] The tumor presents as a solitary, firm, painless, dermal or subcutaneous mass. It slides freely over the underlying tissue and the overlying skin has a reddish or blue hue in about 24% of the patients. On stretching the overlying skin, it may show the "tent sign" with multiple facets and angles. Pilomatricoma most commonly occurs in the head and neck, with cervical, temporal, eyelid and preauricular regions being the most frequently reported locations. Growth is usually slow and benign. The tumor diameter ranges from 0.5 to 3 cm. A malignant variant with distant metastases has been described. [2],[3]

Pilomatricomas are generally solitary tumors; multiple tumors occurring synchronously account for 2-3.5% of those reported. Multiple or recurring tumors may be found in association with Gardner syndrome, myotonic muscular dystrophy, sarcoidosis, skull dysostosis, Rubenstein-Taybi syndrome and Turner syndrome. [2]

The pilomatricoma lesions rarely develop simultaneously. Instead, they have a tendency to develop in intervals of one to several years. [2],[3]

In the differential diagnosis, it may be necessary to rule out midline dermoid cysts in the neck, parotid tumors in the preauricular region and adenopathy, calcified hematoma and lipoma in other sites. Pilomatricoma should be differentiated from epidermal and dermoid cysts. [2]

Histopathologically, the tumor is sharply demarcated. Embedded in a rather cellular stroma, irregularly shaped islands of epithelial cells are present. As a rule, two types of cells, basophilic cells and shadow cells, comprise the islands. [4] Shadow cells are enucleated and are formed by keratinization of the basaloid cells, which decrease in number as the neoplasm ages. [2] With the von Kossa stain, calcium deposits are found in approximately 75% of the tumors. Areas of ossification are seen in 15-20% of the cases. Sometimes, melanin deposition and transepidermal elimination have also been described. [4] For definitive diagnosis and because spontaneous regression is never observed, complete surgical excision is the treatment of choice. [2]

References
1.
MacKie RM, Calonje E. Tumours of skin appendages. In: Burns T, Breathnach S, Cox GN, Griffiths C, editors. Rook's Textbook of Dermatology. 7 th ed. Massachusetts: Blackwell publishing; 2004. p. 37.9-10.
th ed. Massachusetts: Blackwell publishing; 2004. p. 37.9-10.'>[Google Scholar]
2.
Avci G, Akan M, Akoz T. Simultaneous multiple pilomatrixomas. Pediatr Dermatol 2006;23:157-62.
[Google Scholar]
3.
Lan MY, Lan MC, Ho CY, Li WY, Lin CZ. Pilomatricoma of the head and neck -A retrospective review of 179 Cases. Arch Otolaryngol Head Neck Surg 2003;129:1327-30.
[Google Scholar]
4.
Klein W, Chan E, Seykora JT. Tumors of the epidermal appendages. In: Elder ED, Elintsas R, Bernett L, Johnson JR, Murphy GF, editors. Lever's histopathology of the skin. 9 th ed. Philadelphia: Lippincott Williams and Wilkins; 2005. p. 879-80.
th ed. Philadelphia: Lippincott Williams and Wilkins; 2005. p. 879-80.'>[Google Scholar]

Fulltext Views
1,330

PDF downloads
724
Show Sections