Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current Issue
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
Images in Dermatology
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Media and news
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Images
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Reviewers 2022
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Snippets
Special Article
Specialty Interface
Studies
Study Letter
Study Letters
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Systematic Review and Meta-Analysis
Systematic Reviews and Meta-analyses
Systematic Reviews and Meta-analysis
Tables
Technology
Therapeutic Guideline-IADVL
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
Therapy Letters
View Point
Viewpoint
What’s new in Dermatology
Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current Issue
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
Images in Dermatology
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Media and news
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Images
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Reviewers 2022
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Snippets
Special Article
Specialty Interface
Studies
Study Letter
Study Letters
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Systematic Review and Meta-Analysis
Systematic Reviews and Meta-analyses
Systematic Reviews and Meta-analysis
Tables
Technology
Therapeutic Guideline-IADVL
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
Therapy Letters
View Point
Viewpoint
What’s new in Dermatology
View/Download PDF

Translate this page into:

Letter to the Editor - Therapy Letter
2017:83:6;720-721
doi: 10.4103/ijdvl.IJDVL_260_17
PMID: 28980537

Blastomycosis-like pyoderma: Novel use of potassium iodide

Santhi Kiran Borra1 , Dincy C. V. Peter1 , Nirmal Balakrishnan1 , Susanne Pulimood1 , Mandeep Bhindra2
1 Department of Dermatology, Venereology and Leprosy, Christian Medical College, Vellore, Tamil Nadu, India
2 Department of Pathology, Christian Medical College, Vellore, Tamil Nadu, India

Correspondence Address:
Dincy C. V. Peter
Department of Dermatology, Venereology and Leprosy, Christian Medical College, Vellore, Tamil Nadu
India
Published: 04-Oct-2017
How to cite this article:
Borra SK, Peter DC, Balakrishnan N, Pulimood S, Bhindra M. Blastomycosis-like pyoderma: Novel use of potassium iodide. Indian J Dermatol Venereol Leprol 2017;83:720-721
Copyright: (C)2017 Indian Journal of Dermatology, Venereology, and Leprology

Sir,

Blastomycosis-like pyoderma, an unusual form of pyoderma presenting with large verrucous plaques studded with multiple pustules and draining sinuses, is seen in immunocompromised patients with chronic myeloid leukemia, underlying neoplasm, diabetes mellitus, and alcoholism.[1] The treatment of blastomycosis-like pyoderma can be challenging. We report a case of blastomycosis-like pyoderma which responded favourably to saturated solution of potassium iodide.

A 57-year-old lady presented with asymptomatic lesions over her left leg for last 1 year. Initially a painless papule developed over her shin, which gradually enlarged to form a plaque with central ulceration and peripheral extension to attain the present form. There was no history of trauma. Her general and systemic examinations were unremarkable. Cutaneous examination revealed a well-defined large plaque, sized 18 × 13 cm with central scarring, peripheral hyperkeratotic crust, and ulceration over the left shin and a similar smaller plaque over the left ankle [Figure 1a] and [Figure 1b]. Left inguinal lymphadenopathy was noted.

Figure 1a: Well-defined large plaque with central scarring and peripheral hyperkeratotic crust and ulceration over the left shin
Figure 1b: Well-defined plaque with central scarring and peripheral hyperkeratotic crust over the left ankle

The clinical differential diagnoses included lupus vulgaris, atypical mycobacterial infection, chromoblastomycosis, and cutaneous nocardiosis. Her investigations were within normal limits except for an elevated c-reactive protein and blood sugars (postprandial sugar – 218 mg/dl). Mantoux test was negative. Histopathology showed pseudoepitheliomatous hyperplasia and upper dermal abscesses with predominantly neutrophilic infiltrate [Figure 2a] and [Figure 2b]. There were no granulomas and special stains were negative for fungal elements. Tissue bacterial cultures grew Enterococci, Proteus mirabilis, and Escherichia coli repeatedly at different occasions. The tissue fungal and mycobacterial cultures were negative.

Figure 2a: Skin biopsy showing pseudoepitheliomatous hyperplasia with multiple upper dermal abscesses. H and E, ×100
Figure 2b: Skin biopsy showing predominant neutrophilic dermal infiltrate. H and E, ×400

A diagnosis of blastomycosis-like pyoderma was made as our patient met 4 of 6 criteria proposed by Su, Duncan and Perry: (1) Isolation of a pathogenic microbe; (2) clinical presentation of large verrucous plaques with multiple pustules and elevated borders; (3) microscopic findings of pseudooepitheliomatous hyperplasia with neutrophil-rich microabscesses within the epidermis and dermis; (4) negative culture for deep fungi, atypical mycobacteria, and mycobacterium tuberculosis; (5) negative fungal serology test result; and (6) bromide level in the blood within reference range.[2] The first four criteria were present in our patient.

The patient was initiated on tablet metformin 500 mg twice a day for diabetes, following which her glycemic control improved. Specific therapy included several courses of systemic antibiotics including piperacillin-tazobactam, linezolid, amikacin, and meropenem based on antibiograms for a period of 2 months and was later continued on doxycycline. Acitretin was given for 4 months along with adjuvant therapies such as cryotherapy, curettage, intralesional steroids, and ablative carbon dioxide laser. The modalities were used along with acitretin one at a time and discontinued before the next modality of treatment as the patient did not show significant improvement in skin lesions. She developed new lesions even while on acitretin and antibiotics. Acitretin was stopped due to financial constraints and was continued on co-trimoxazole and doxycyline. As there was no significant clinical improvement, saturated solution of potassium iodide was added in a dose of three drops thrice daily with a gradual increase to 12 drops thrice daily. Resolution of vegetating granulation tissue was observed within 1 month and complete remission in 3 months [Figure - 3]. Thereafter, saturated solution of potassium iodide was tapered and stopped over the next 3 months.

Figure 3: Resolution of lesions after 3 months of saturated solution of potassium iodide

Blastomycosis-like pyoderma is an unusual vegetative proliferating tissue response to an infection. Common organisms isolated from tissue cultures of patients with blastomycosis-like pyoderma include Staphylococcus aureus, Beta-hemolytic streptococci, Pseudomonas aeruginosa, Proteus mirabilis, E. coli, and Candida albicans and anaerobes including Prevotella and Corynebacterium. As the condition is unresponsive to antibiotics alone, the role of these bacteria in the pathogenesis of the condition is unclear.[1]

Blastomycosis-like pyoderma is usually managed with systemic antibiotics. Recent reports have demonstrated the use of acitretin with good response.[3] Other treatment options include topical and intralesional steroid, saturated solution of potassium iodide, dapsone, cyclosporine, cryosurgery, electrodessication and CO2 laser ablation.[4] Our patient showed remarkable response with saturated solution of potassium iodide, despite the failure of all other therapeutic modalities. There was complete resolution within 3 months and she is in complete remission for more than 6 months. Saturated solution of potassium iodide acts by decreasing the inflammatory reaction, suppressing the neutrophil chemotaxis, and release of their toxic intermediates.[5]

We postulate that saturated solution of potassium iodide is a good therapeutic option in patients with blastomycosis-like pyoderma based on our patient's response. As it is cheap, easily available, and with minimal side effects, we propose saturated solution of potassium iodide as the first line agent along with an appropriate antibiotics to treat blastomycosis-like pyoderma.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

References
1.
Burns T, Breathnach S, Cox N, Griffiths C, editors. Bacterial infections. In: Rook's Textbook of Dermatology. 8th ed. Edinburgh: Blackwell Publishing Ltd.; 2010; Vol 2. p. 30.77-30.78.
[Google Scholar]
2.
Su WP, Duncan SC, Perry HO. Blastomycosis-like pyoderma. Arch Dermatol 1979;115:170-3.
[Google Scholar]
3.
Lee YS, Jung SW, Sim HS, Seo JK, Lee SK. Blastomycosis-like pyoderma with good response to acitretin. Ann Dermatol 2011;23:365-8.
[Google Scholar]
4.
Su O, Demirkesen C, Onsun N. Localized blastomycosis-like pyoderma with good response to cotrimoxazol and cryotherapy. Int J Dermatol 2004;43:388-90.
[Google Scholar]
5.
Schulz EJ, Whiting DA. Treatment of erythema nodosum and nodular vasculitis with potassium iodide. Br J Dermatol 1976;94:75-8.
[Google Scholar]

Fulltext Views
2,894

PDF downloads
800
Show Sections