Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Art & Psychiatry
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Conference Oration
Conference Summary
Continuing Medical Education
Cosmetic Dermatology
Current Best Evidence
Current Issue
Current View
Derma Quest
Dermato Surgery
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
Editor Speaks
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
In Memorium
Inaugural Address
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Medicolegal Window
Miscellaneous Letter
Net Case
Net case report
Net Image
Net Letter
Net Quiz
Net Study
New Preparations
News & Views
Observation Letter
Observation Letters
Original Article
Original Contributions
Pattern of Skin Diseases
Pediatric Dermatology
Pediatric Rounds
Presedential Address
Presidential Address
Presidents Remarks
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Review Article
Review Articles
Revision Corner
Self Assessment Programme
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Special Article
Specialty Interface
Study Letter
Study Letters
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Systematic Review and Meta-Analysis
Systematic Reviews and Meta-analyses
Systematic Reviews and Meta-analysis
Therapeutic Guideline-IADVL
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapy Letter
Therapy Letters
View Point
What’s new in Dermatology
View/Download PDF

Translate this page into:

Letter To Editor
doi: 10.4103/0378-6323.35748
PMID: 17921627

Clear cell hidradenoma in a young boy

Reza Yaghoobi1 , Parvin Kheradmand2
1 Department of Dermatology, Ahwaz Jondi Shapour, University of Medical Sciences, Ahwaz, Iran
2 Department of Pathology, Ahwaz Jondi Shapour, University of Medical Sciences, Ahwaz, Iran

Correspondence Address:
Reza Yaghoobi
Department of Dermatology, Emam Khomeini Hospital, 61335, Ahwaz
How to cite this article:
Yaghoobi R, Kheradmand P. Clear cell hidradenoma in a young boy. Indian J Dermatol Venereol Leprol 2007;73:358-359
Copyright: (C)2007 Indian Journal of Dermatology, Venereology, and Leprology
Figure 2: Histopathology showing clear and pale cells (H and E, X200)
Figure 2: Histopathology showing clear and pale cells (H and E, X200)
Figure 1: Solitary tumor with ulcerated surface on the left shoulder
Figure 1: Solitary tumor with ulcerated surface on the left shoulder


Clear cell hidradenoma is an uncommon benign tumor differentiating towards sweat glands. These tumors are variable in size with a small tendency to ulcerate and have a low malignant potential. [1] Usually, these are diagnosed between the fourth and the eighth decade of life, with a peak incidence in the sixth decade. [2] Women are affected more often than men. [3] We present the case of a 14-year-old boy with an ulcerated clear cell hidradenoma.

A 14-year-old boy presented with a progressively enlarging nodule on his left shoulder for the past 1 year. There was no preceding history of trauma involving the affected area. Clinical examination revealed a 1.0 x 0.5cm, firm, nontender, erythematous nodule on the left shoulder with an ulcerated surface [Figure - 1]. There was no regional lymphadenopathy. The boy was otherwise in good health.

The tumor was excised. Histopathological examination revealed a circumscribed nonencapsulated multilobulated tumor centered in the dermis with epidermal connections. The tumor was composed of solid nests of round cells with eosinophilic or clear cytoplasm. There were a few duct-like structures lined by one-layered cuboidal cells [Figure - 2] that were suggestive of clear cell hidradenoma. The postoperative course was uneventful as observed during the follow-up after 3 months.

Mayer first described hidradenoma as a distinct clinical entity. [4] These are benign adnexal neoplasms of uncertain origin. Majority of the investigators consider these neoplasms to be of eccrine origin. However, there are occasional reports supporting an apocrine derivation. Recently, hidradenoma has been classified into two groups; those with eccrine differentiation (poroid hidradenoma) and those exhibiting apocrine differentiation (clear cell hidradenoma). [4] Clear cell hidradenomas are by far the most frequent subtype and account for 95% of all the cases. [2],[5]

Clinically, clear cell hidradenoma presents as a slow growing, solitary, freely mobile and firm nodule. Occasionally, there may be a cystic appearance. The lesions may be skin-colored, red, blue or brown; multiple lesions are rare. There is a predilection for occurrence over the scalp, face, thorax and abdomen; however, the tumor may be located anywhere on the body. [3] Rarely, malignant transformation of clear cell hidradenomas with metastasis has been reported. [2] The presentation of our patient is considered to be unusual because of the early age of onset and clinical picture.

Clear cell hidradenoma is well circumscribed and is sometimes encapsulated. It may be connected to the epidermis and the dermal epithelial lobules may extend into the subcutaneous fat. Tubular lumina of varying sizes are often present within the lobulated masses. These may bifurcate and are usually lined by the cuboidal epithelium and sometimes show glandular structures surrounded by columnar cells. Although it may contain a mixture of solid and cystic areas in varying proportions, clear cell hidradenoma is considered to be a solid tumor. The main histopathologic characteristic of clear cell hidradenoma is the presence of large pale to clear cells with small, monomorphous, round or plump oval and often eccentrically located nuclei. The clear cells contain considerable amount of glycogen; however, in addition, they may show significant amount of PAS - positive, diastase - resistant material along their periphery. [2],[5]

The diagnosis of clear cell hidradenoma solely on the basis of the clinical appearance of the lesion is difficult. The sites of occurrence are nonspecific and similar to other nodulocystic lesions of the skin. The histopathological characteristics of clear cell hidradenoma are distinctive, but the lesion should be differentiated from other conditions where clear cells may be present. Surgical removal with wide margins is recommended for this tumor as there is a high rate of local recurrence and this tumor has the potential for malignant transformation. [3] A review of a large series of patients with clear cell hidradenoma has shown a postsurgical recurrence rate of approximately 10%. This may be attributed to the incomplete resection and the fact that the tumor tissue insinuates through the dermis and subcutaneous tissue. [5]

Feldman AH, Niemi WJ, Blume PA, Chaney DM. Clear cell hidradenoma of the second digit: A review of the literature with case presentation. J Foot Ankle Surg 1996;36:21-3.
[Google Scholar]
Faulhaber D, Worle B, Trautner B, Sander CA. Clear cell hidradenoma in a young girl. Am Acad Dermatol 2000;42:693-5.
[Google Scholar]
Schweitzer WJ, Goldin HM, Bronson DM, Brody PE. Ulcerated tumor on the scalp. Clear-cell hidradenoma. Arch Dermatol 1989;125:985-6.
[Google Scholar]
Gianotti R, Alessi E. Clear cell hidradenoma associated with the Folliculo - Sebaceous - Apocrine unit: Histologic study of five cases. Am J Dermatopathol 1997;19:351-7.
[Google Scholar]
Ozawa T, Fujiwara M, Nose K, Muraoka M. Clear cell hidradenoma of the Forearm in a young boy. Pedia Dermatol 2005;22:450-2.
[Google Scholar]

Fulltext Views

PDF downloads
Show Sections