Comparative Efficacy of Penicillin and Doxycycline in Gonococcal Urethritis

Abstract

Ninety two episodes of gonococcal urethritis treated with one of the following regimens viz: (A) 3 m. u. of fortified procaine penicillin made by adding 1 m.u. of crystalline penicillin to 2 m.u. of fortified procaine penicillin intramuscularly with one gram of probenecid orally, (B) 3 m.u. of above fortified procaine penicillin intramuscularly alone, and (C) 400 mg single oral dose of doxycycline produced success rates of 95,76.2 and 66.7% respectively. Post gonococcal urethritis was detected in 37% patients. Thirty four (45.94%) of the 74 isolates of N. gonorrhoeae were relatively resistant (MIC 0. 12 units ml) to penicillin. None of the 74 Neisseria gonorrhoeac strains was beta lactamase producing.