Generic selectors
Exact matches only
Search in title
Search in content
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Retraction
Review
Review Article
Review Articles
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Special Article
Specialty Interface
Studies
Study Letter
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Tables
Technology
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
View Point
Viewpoint
What’s new in Dermatology
Original Article
2003:69:2;140-141
PMID: 17642860

Comparative immunological and histopathological study in fifty cases of mucosal/nonmucosal lichen planus

RR Mittal, RL Walia, P Sharma, A Singla
 Dept. of Skin & VD, Rajinder Hospitals, Patiala - 147 001, India

Correspondence Address:
R R Mittal
Dept. of Skin & VD, Rajinder Hospitals, Patiala - 147 001
India
How to cite this article:
Mittal R R, Walia R L, Sharma P, Singla A. Comparative immunological and histopathological study in fifty cases of mucosal/nonmucosal lichen planus. Indian J Dermatol Venereol Leprol 2003;69:140-141
Copyright: (C)2003 Indian Journal of Dermatology, Venereology, and Leprology

Abstract

Lichen planus is a common disorder and 40-50% of LP patients also reveal mucosal lesions. It is well known that mucosal LP lesions take very long to heal in comparison to cutaneous lesions. Rarely erosive mucosal LP can turn malignant. Both CMI and humoral immunity may play role in aetiopathogenesis of LP.
Present study was conducted to study and compare CMI, Humorol Immunity, histopothology in mucosal and nonmucosal LP.
Keywords: CMI, humoral immunity, Mucosal lesions

Introduction

Lichen planus occurs in 0.9-1.2% of general population and in 40-50% cases both oral and cutaneous lesions are present,′ but oral lesions can be the only manifestation in 15-20%.[2] Probably lichen planus represents a reflection of cell mediated immune response as mononuclear cell infilterate (mainly T Lympocytes) and increased number of Langerhans cells are present in both epidermis and dermis.[3] Humoral immunity could also have possible role in aetiopathogenesis of LP[4].

HistopathologicaIly, LP shows characteristically hyperorthokeratosis, wedge shaped hypergranulosis, acanthosis, basal cell liquefaction degeneration, saw toothed rete ridges and band like lymphocytic infilterate.[5]

Materials and Methods

A total of fifty cases clinically diagnosed as lichen planus were taken from outpatients department of DermatoVenereology, Ralindra Hospital, Patiala. Detailed clinical history, complete general physical and systemic examinations were done. Peripheral T-lymphocyte counts, serum immunoglobulins (IgG, IgM, IgA) estimation and histopathology (H&E) were done in all the cases.

Statistical analysis and evaluation of differences in cellular immunity (peripheral T-lymphocyte counts), humoral immunity in mucosal/ nonmucosal LP cases.

Results

As shown in [table-I], 39 out of 50 cases had only cutaneous lesions and 11 had mucosal along with cutaneous lesions. LP vulgaris was commonest type (37) and 10 of them had mucosal lesions.

Mucosal lesions were seen as white lacy reticular pattern and descrete yellow papules on inner side of cheeks and lips. All lesions were nonerosive.

[Table-II] reveals statistically highly significant decrease in peripheral T-cell counts in patients with mucosal involvement.

As shown in [table-III], there was a statistical significant decrease in levels of IgG, immunoglobulins while statistically nonsignificant change in levels of IgM and IgA immunoglobulins in patients with mucosal LP

As shown in [table-IV], significant differences in histopathology of mucosal LP were parakeratosis, absence of granular layer, prominent koilocytes, absence of saw toothed rete ridges and lesser number of mononuclear cell in lichenoid infilterate.

Discussion

The investigations in present study showed statistically highly significant decrease peripheral T -cell counts, in mucosal LP suggesting decreased cellular immunity in them versus cutaneous LP Also levels of IgG immunoglobulins were statistically significantly decreased suggesting more suppression of humoral immunity in mucosal LP.

On histopathology, parakeratosis, absence of stratum granulosum, prominence of koilocytes, absence of saw toothed rete ridges and lesser lichenoid infilteratewere prominent features in mucosal LP versus cutaneous LP.

References
1.
Joseph J Dusek, William G Frick. Lichen planus: oral manifestations and suggested treatments. J Oral Maxillofacial Surgery 1982; 40:240-244.
[Google Scholar]
2.
Warin RP, Crabb HSM, Darling AI. Lichen planus of the mouth. Br Med J 1958;983-984.
[Google Scholar]
3.
Arndt Kenneth A. Lichem planus. In: Dermatology in General Medicine. Editors: Thomas B Fitzpatrick, Arthur Z Eisen, Klaus Wolff, Irwin M, Freeburg and K Frank Austin, McGraw Hill Book Company, Third Edition, 1987;1:967-973.
[Google Scholar]
4.
Mann RH, Wallington TB, Warin RP Lichen planus with late onset hypogomma globulinaemia, a casual relationship?
[Google Scholar]
5.
British FA. Histopathology of lichen planus based on one hundred biopsies. J Invest Dermatol 1967;48:143.
[Google Scholar]
Show Sections