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Original Article
2003:69:2;138-139
PMID: 17642859

Comparison of efficacy of topical clindamycin and nicotinamide combination with plain clindamycin for the treatment of acne vulgaris and acne resistant to topical antibiotics

VR Sardesai, VM Kambli
 Dept. of Dermatology & Venereology, Bharti Vidyapeeth Deemed University Medical College, Dhankawadi, Pune - 411 043, Maharashatra, India

Correspondence Address:
V R Sardesai
Dept. of Dermatology & Venereology, Bharti Vidyapeeth Deemed University Medical College, Dhankawadi, Pune - 411 043, Maharashatra
India
How to cite this article:
Sardesai V R, Kambli V M. Comparison of efficacy of topical clindamycin and nicotinamide combination with plain clindamycin for the treatment of acne vulgaris and acne resistant to topical antibiotics. Indian J Dermatol Venereol Leprol 2003;69:138-139
Copyright: (C)2003 Indian Journal of Dermatology, Venereology, and Leprology

Abstract

A total of 75 patients with inflammatory acne vulgaris were divided into three groups. Group A was treated with combination of 4% nicotinamide and 1% clindamycin combination, Group B was treated with plain 1 % clindamycin and Group C which was considered to have resistance to local antibiotics due to no response to treatment was treated with the combination. At the end of 8 weeks the results were compared. It was concluded that addition of nicotinamide was of not much value in treating inflammatory acne and results were some as for plain clindamycin and also the combination did not offer much relief in treatment of resistant acne.
Keywords: Acne Vulgaris, Nicotinamide, Clindamycin

Introduction

Topical antibiotics have been used widely as an effective treatment modality in treatment of acne for last 30 years.[1],[2] But emergence of resistant strains of Pacnes to commonly used antibiotics such as erythromycin and clindamycin is leading to therapeutic failure. Nicotinamide is a potent anti-inflammatory agent used in various dermatological disorders.[3] It was thought it would be helpful drug to treat acne by reducing the incidence of resistance.[4]

Materials and Methods

Seventy-five patients in the age group of 16-35 years were selected from our patients attending Dermatology Clinic in the Dermatology department of Bharati Hospital.

All patients had inflammatory acne vulgaris i.e. Grade II and III.

Parameters for grading were as follows:

Patients with only comedones, severe nodulocystic acne, pregnant women, lactating mothers, taking systemic medicines, having gastro-intestinal problems and any other major illness were excluded from study.

Written consent was taken from every patient. Detail history about onset, distribution of lesions, treatment taken and exacerbating factors was noted. Acne count, distribution and grading were done. Seventy-five patients were divided into 3 groups.

Group A: 28 fresh cases- Treated with 4% nicotinamide+ 1 % clindamycin

Group B: 29 fresh cases treated with 1% clindamycin.

Group C: 18 cases-Treated with 4% nicotinamide +1 % clindamycin (probably resistant cases who did not respond satisfactorily to topical antibiotics)

Follow up was done after 4 and 8 weeks and final results were drawn according to physicians′ global evaluation for inflammatory acne vulgaris.

Analysis was done for the 3 groups. X2 te: for significance was applied tt compare the results between Group A and Group B.

Results

Results are shown in tables I and II for Group A and Group B respectively. [Table - 3] show comparison between Group A and Group B. [Table - 4] shows the response in Group C. and Group B.

Discussion

In our study 50% patients from Group A showed moderate response and 17.5% showed excellent response and only 20% showed poor or no response. No side effects were seen except very mild burning sensation in few patients.

In Group B 44.82% of patients showed moderate response while 13.79% showed excellent response and 33.49% no response.

Thus there is no difference in the efficacy of both plain clindamycin and its combination with nicotinamide. Applying X2 test resulted in value of p< 0.05, hence the null hypothesis was accepted concluding there is no difference in the efficacy of both the agents.

This means that combination of 4% nicotinamide and 1 % clindamycin is effective in fresh cases on acne vulgaris but its efficacy is comparable to plain 1 % clindamycin and of no added advantage.

In group C, 55.54% patients showed poor or no response, 27.7% moderate response and only 16.6% excellent response. So it again shows that addition of nicotinamide to clindamycin is of no great value in treating acne resistant to topical antibiotics.

References
1.
Resh William, Stoughton Richard. Topically applied antibiotics in acne vulgaris. Arch Dermatol 1976;112: 182-184.
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2.
Beck LE. Topical clindamycin therapy for acne vulgaris. Arch Dermatol [1]1981;117:482-485.
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3.
Mills CM, Hill SA, Mark R. Transdermal nicotinamide suppresses cutaneous inflammation. Arch Dermatol 1997;133:823-825.
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4.
Shalita AR. Topical nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris. int J Dermatol 1995;34: 434-437.
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5.
Allen BA, Smith Graham. Various parameters for grading acne vulgaris. Arch Dermatol 1982;1 18: 23-25.
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