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Congenital familial acral vitiligo
Correspondence Address:
Rishi Bhargava
C-32, Peeyush Path, Bapu Nagar, Jaipur - 302 015
India
| How to cite this article: Jain DK, Bhargava P, Mathur DK, Agarwal U S, Bhargava R. Congenital familial acral vitiligo. Indian J Dermatol Venereol Leprol 1997;63:193 |
Abstract
A 22-year-old female presented with vitiliginous lesions on her hands and feet since birth. Similar lesions at similar sites were present in 4 other family members. The trait appeared to have autosomal dominant inheritance with variable penetrance. |
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Vitiligo is characterized by the presence of well-defined milky-white macular lesions devoid of identifiable melanocytes.[1]In about 30-40% cases, a family history has been found in 1st and 2nd degree relatives.[1]We recently came across a 22-year-old female with acrally distributed vitiligo lesions since birth. Four other family members were also affected.
Case Report
A 22-year-old female was referred to us with vitiliginous lesions on her hands and feet since birth. Examination showed milky-white macules and patches distributed on dorsal aspect of her both hands and feet. Rest of her body was free from similar lesions. Other autoimmune abnormalities were excluded clinically and by relevant laboratory investigations. Biopsy confirmed the diagnosis of vitiligo.
A positive family history of similar lesions at similar sites was obtained from brother, sister, uncle and her grand father.
Discussion
These family members had a unique acral distribution of vitiligo lesions and trait appeared to have autosomal dominant inheritance with variable penetrance[Figure - 1].
| 1. |
Mosher DB, Fitzpatric TB, Hori Y et al. Disorders of melanocytes. In: Dermatology in General Medicine, 4th edition, Editors, Fitzpatrick T B, Eisen A Z, Wolff K, Mc Graw-Hill Inc, New york 1993;923-933.
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![[Figure - 1]](#fig_ijdvl_1997_63_3_193_22747_1.jpg){kind=link}