Correlation of Circulating Antibody Titres with Activity of Disease in Pemphigus
|How to cite this article:
Saxena U, Misra R S, Chandra M. Correlation of Circulating Antibody Titres with Activity of Disease in Pemphigus. Indian J Dermatol Venereol Leprol 1989;55:224-226
AbstractCorrelation of antibody tires with the clinical severity of the disease was done in 58 patients having pemphigus. Serial determinations of the antibody titre-s were done in 40 patients ranging from two to eight follow-up samples. Titre of the antibody correlated with the cases. In 6 disease, activity in 70% of the cases. In 6 patients with mild disease, the antibody titre was persistently high, while in 11 patients with moderate to severe disease activity, antibody was nil or present in - low- titres. While the former group may indicate better prognosis and prolonged remissions the latter situation could be as a result of immune failure either due to fulmlinant disease or due to the immunosuppressive effect of the, high doses of the drugs used to control the disease.