Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current Issue
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
Images in Dermatology
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Media and news
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Images
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Reviewers 2022
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Snippets
Special Article
Specialty Interface
Studies
Study Letter
Study Letters
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Systematic Review and Meta-Analysis
Systematic Reviews and Meta-analyses
Systematic Reviews and Meta-analysis
Tables
Technology
Therapeutic Guideline-IADVL
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
Therapy Letters
View Point
Viewpoint
What’s new in Dermatology
Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current Issue
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
Images in Dermatology
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Media and news
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Images
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Reviewers 2022
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Snippets
Special Article
Specialty Interface
Studies
Study Letter
Study Letters
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Systematic Review and Meta-Analysis
Systematic Reviews and Meta-analyses
Systematic Reviews and Meta-analysis
Tables
Technology
Therapeutic Guideline-IADVL
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
Therapy Letters
View Point
Viewpoint
What’s new in Dermatology
View/Download PDF

Translate this page into:

Letter to the Editor
2010:76:4;409-412
doi: 10.4103/0378-6323.66584
PMID: 20657126

Cutaneous metastases in 42 patients with cancer

Esther Una Cidon
 Medical Oncology Service, Clinical University Hospital of Valladolid, Spain

Correspondence Address:
Esther Una Cidon
Medical Oncology Department, Clinical University Hospital, C/ Ramon y Cajal s/n, 47005 Valladolid
Spain
How to cite this article:
Cidon EU. Cutaneous metastases in 42 patients with cancer. Indian J Dermatol Venereol Leprol 2010;76:409-412
Copyright: (C)2010 Indian Journal of Dermatology, Venereology, and Leprology

Sir,

Cancer metastases are considered as the most devastating phase of malignancies. [1] Metastasis is defined as a neoplastic lesion arising from a malignant tumor which is not in contiguity or in close proximity with the same tissue. [2] Although there are many frequent locations, the incidence of cutaneous metastases is rare and account for nearly 0.7-9% of all tumoral implants [3] and in approximately 80% of the cases skin metastases (SM) are developed in the subsequent evolution of the primary tumor. [3] In few cases, they are the first evidence or a sign of recurrence of a known tumoral disease. This fact implies that although there are several morphological types of SM, in current clinical practice, it is not generally performed confirmatory biopsies. In these cases, the diagnosis is based on clinical appereance. Although the most common lesions are multiple or solitary infiltrating papules and/or nodules which might be easy to diagnose, there are also other variants which are rare such as alopecia neoplastica, zosteriform pattern or chest armor or the interesting variants mimicking radiation dermatitis which have been reported barely and they could be difficult to diagnose without histopathological study. These variants have a poorer prognosis and are due to the spread of the malignant cells along the subcutaneous lymphatics leading to blockade of the lymph ducts.

Generally all these lesions are considered a grave prognostic sign [3] due to coexistence with visceral lesions (lung, liver or other multiple organs). The most common sites affected are the head (50%) followed by the trunk (40%) and extremities (10%). [4],[5] These lesions are the result of skin infiltration by a distant neoplasia. [1],[2],[3] Although melanoma is the most common origin, it is preceded by other tumors, being the most frequent correlated with the most common cancer in each sex. [6] Globally, breast cancer is the second etiology of SM and these lesions usually occur in the skin overlying or proximal to the area of the primary tumor. [7]

With this background, we can conclude that it could be relevant to know the incidence and most common pattern of these lesions in our institution to facilitate the rapid recognition and the prompt treatment of SM and the global neccessity of diagnostic biopsies.

With this aim we have conducted recently a descriptive retrospective analysis of clinical and histopathological data of all patients diagnosed with skin metastases between January 2005 and December 2008 in our department. We tried to describe the most frequent origins of these lesions in our environment, to describe its clinical appereance and the necessity of diagnostic biopsies.

We detected 42 patients out of 700 revised (6%) (male 28, female 14) with a median age of 54 years (range, 31-76 years). The most common primary tumor in men was melanoma (32%) followed by gastrointestinal adenocarcinoma (26%). In women the most common primary tumor was breast cancer (41%), followed by melanoma (33%). In 4 patients it was impossible to identify the primary tumor. In these cases skin metastases were the only evidence of malignant disease.

Although there are several variants of cutaneous metastases based on its appereance, the most common clinical presentation in our study was asymptomatic subcutaneous solitary nodule (34%), followed by multiple painful and/or burning nodules (13%). One patient had multiple and painful/burning papules and nodules occupying the whole area of the primary breast cancer and the skin over the contralateral breast prosthesis following a prior breast cancer [Figure - 1]a and b and another had a metastasis mimicking radiation dermatitis eighteen months after she had ended adjuvant radiotherapy for breast cancer [Figure - 2]. [8] These two patients presented multiple lung and mediastinal nodes metastases and the last one also bone metastases. In both of these patients SM were the first sign of recurrence. Only in 3 patients the SM were the first sign of tumor disease.

The relationship between primary tumor and clinical type of metastases are described in [Table - 1].

Biopsies were performed in those 12 patients (28,5%), whose pathological findings were positive for melanoma followed by carcinoma. Whereas, in 31 patients SM were associated with visceral and lymph node metastases.

In our study, we obtained a mortality rate at three and six months after diagnosis of SM of 18% and 36%, respectively. The most usual type of treatment is systemic therapy according to the histopathological type of tumor disease and the overall prognosis depends on the pathology and biological behavior of the primary neoplasm and its response to the treatment. However, as a rule it is established that the expected survival is less than 1 year after the diagnosis.

The SM usually appear in advanced stages of cancer or as a mode of recurrence of a known tumor disease making relatively easy the diferential diagnosis based on clinical appereance. In very few cases they are the first evidence of neoplasm.

Although generally they have poor prognosis, we have obtained a very low survival rate, poorer than the survival reported in other studies, [3],[5] probably because of the multiplicity of lesions and associated visceral injuries in the population studied. Other studies have reported an overall survival at 1, 3 and 5 years of 50%, 20% and 0%, respectively. This overall survival rate varies with the presence or the absence of disseminated disease.

Despite of these results, we are convinced with the relevance to start early treatment in order to avoid complications such as ulceration, pain, infection or others which could deteriorate the quality of life of these patients.

References
1.
De Vita VT, Hellman S, Rosemberg SA. Treatment of Metastatic Cancer. In: De Vita, editors. Cancer: Principles and Practice of Oncology, 6 th ed. Philadelphia, VT Lippincott Williams and Wilkins; 2001.
[Google Scholar]
2.
De Vita VT, Hellman S, Rosemberg SA. Principles of Medical Oncology. In: De Vita, editors. Cancer: Principles and Practice of Oncology, 6 th ed. Philadelphia, Lippincott Williams and Wilkins; 2001.
[Google Scholar]
3.
Naser AMB, Zaki MS, Brunner M, Wollina V, Zouboulis CC. Cutaneous metastasis in internal malignancy. Egypt Dermatol Online J 2007;3:1.
[Google Scholar]
4.
Brenner S, Tamir E, Maharshak N, Shapira J. Cutaneous manifestations of internal malignancies. Clin Dermatol 2001;19:290-7.
[Google Scholar]
5.
Krathen RA, Orengo IF, Rosen T. Cutaneous metastases: a meta-analysis of data. South Med J 2003;96:164-7.
[Google Scholar]
6.
Lookingbill DP, Spangler N, Sexton FM. Skin involvement as the presenting sign of internal carcinoma: a retrospective study of 7316 cancer patients. J Am Acad Dermatol 1990;22:19-26.
[Google Scholar]
7.
Prabhu S, Pai SB, Handattu S, Kudur MH, Vasanth V. Cutaneous metastases from carcinoma breast: The common and the rare. Indian J Dermatol Venereol Leprol 2009;75:499-502.
[Google Scholar]
8.
Gugle A, Malpathak V, Zawar V, Deshmukh M, Kote R. Carcinoma erysipeloides: An unusual presentation mimicking radiation dermatitis. Dermatol Online J 2008;14:26.
[Google Scholar]

Fulltext Views
1,724

PDF downloads
1,119
Show Sections