Cutaneous metastasis as the primary manifestation of large cell neuroendocrine carcinoma of lung

Asli Akin Belli¹ , Emine Dervis² , Nazmi Geyik³

¹ Department of Dermatology, Mugla Sitki Kocman University Training and Research Hospital, Mugla, Turkey, Turkeyxs
² Department of Dermatology, Haseki Training and Research Hospital, Istanbul, Turkey
³ Department of Dermatology, Medicine Hospital, Istanbul, Turkey

Correspondence Address:
Asli Akin Belli
Orhaniye Mah., Ismet Catak Cad., 48000 Mugla
Turkeyxs

A 55-year-old male presented with asymptomatic, 1 to 3 cm, erythematous nodules on the scalp and beard for a month [Figure - 1]a. Our differential diagnoses included lymphoma, pseudolymphoma and cutaneous metastasis. Histopathological examination showed a poorly differentiated metastatic tumor. Immunohistochemical stains were positive for synaptophysin, chromogranin a, cytokeratin 7 and vimentin indicating a metastatic large cell neuroendocrine carcinoma. Chest radiography showed a round opacity in the middle zone of the right lung representing the primary tumour [Figure - 1]b. Chemotherapy with cisplatin was initiated but he died 4 months later.

Figure 1: (a) Well-demarcated, erythematous nodules on the scalp and beard area. (b) Chest radiography showing a round opacity in the middle zone of the right lung (arrow)