Effect of Prothionamide on the Infectivity of Lepromatous Leprosy
|How to cite this article:
Girdhar A, Girdhar B K, S, Ramu G, Lavania R K, Desikan K V. Effect of Prothionamide on the Infectivity of Lepromatous Leprosy. Indian J Dermatol Venereol Leprol 1985;51:198-201
AbstractTo study the effect of prothionamide. on the infectivity of untreated lepromatous patients 20 cases were randomly given either 250 mg or 500 mg prothionamide monotherapy daily for 2 months. All patients tolerated the drug well. Clinical improvement with healing of mucosal ulcers was seen in 13 of the 16 cases. Nasal smears become negative in all the cases within 2 months. Mouse footpad inoculation done from biopsy specimens/skin scrape suspension- s became non infective to mice in all the cases within the trial period. There was a substantial reduction in ,the MI and histopathology showed complete fragmentation of the bacilli with a significant increase in the lymphocyte content. The -findings suggest a rapid bactericidal effect and a similar, use fullness on both the doses of the drug for the treatment of multibacillary leprosy.