Elucidation and management of 30 patients of drug induced toxic epidermal necrolysis (DTEN)
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Kaur S, Nanda A, Sharma K V. Elucidation and management of 30 patients of drug induced toxic epidermal necrolysis (DTEN). Indian J Dermatol Venereol Leprol 1990;56:196-199
AbstractThirty patients of drug induced toxic epidermal necrolysis (DTEN) were seen over a period of 7 years. They included 16 males and 14 females and their ages ranged from 5 months to 60 years with a mean of 23 years. The epidermal necrosis affected 20-100% of the body surface area. The oral, nasal and conjunctival mucosae were involved in all the cases. Antitubercular drugs were the most common offending agents (1/3rd of the patients) followed by anticonvuIsants, sulfonamides, butazones, and antibiotics. TEN proved fatal in 8 (27%) patients with septicemia being the most common predisposing factor. Other factors which contributed to fatal outcome were underlying severe disease in 2 patients and disseminated intravascular coagulation in one.