Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Art & Psychiatry
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Conference Oration
Conference Summary
Continuing Medical Education
Cosmetic Dermatology
Current Best Evidence
Current Issue
Current View
Derma Quest
Dermato Surgery
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
Editor Speaks
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
In Memorium
Inaugural Address
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Medicolegal Window
Miscellaneous Letter
Net Case
Net case report
Net Image
Net Letter
Net Quiz
Net Study
New Preparations
News & Views
Observation Letter
Observation Letters
Original Article
Original Contributions
Pattern of Skin Diseases
Pediatric Dermatology
Pediatric Rounds
Presedential Address
Presidential Address
Presidents Remarks
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Review Article
Review Articles
Revision Corner
Self Assessment Programme
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Special Article
Specialty Interface
Study Letter
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Systematic Reviews and Meta-analyses
Systematic Reviews and Meta-analysis
Therapeutic Guideline-IADVL
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapy Letter
View Point
What’s new in Dermatology

Translate this page into:

Original Article
PMID: 17656862

Epidermal and sebaceous nevi treated with carbon dioxide laser

Kaushal K Verma, EM Ovung
 Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, 110 029, India

Correspondence Address:
Kaushal K Verma
Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, 110 029
How to cite this article:
Verma KK, Ovung E M. Epidermal and sebaceous nevi treated with carbon dioxide laser. Indian J Dermatol Venereol Leprol 2002;68:23-24
Copyright: (C)2002 Indian Journal of Dermatology, Venereology, and Leprology


Eight patients, 2 males and 6 females, between 10-21 years in age with epidermal (4) and sebaceous nevi (4) were taken up for this study. The lesions in all the patients were vaporized with the indigenously developed carbon dioxide laser. All the patients were evaluated at 1, 2, 4, 8 and 12 weekly visits. The final evaluation was done at the 12 weekly visit to assess the overall response to the treatment and side effects. The patients were then followed up every month for 6 months to look for any recurrence. All the patients responded to the treatment. Three patients each with epidermal and sebaceous nevi had 8090% improvement while I patient each with above disorders had % and 60% improvement respectively. Transient hypopigmentation was seen in all the patients. There were no other significant side effects.
Keywords: CO2 laser, Nevi, Therapy, Laser


Epidermal and sebaceous nevi are difficult to treat and often the therapeutic outcome is unsatisfactory or cosmetically unacceptable. CO2 laser is very versatile laser which can coagulate, vaporize or excise the tissue, therefore it has been successfully used to treat many lesions which were considered untreatable.[1],[2] Here we report our experience of treating 8 patients with epidermal and sebaceous nevi with good results.

Materials and Methods

Eight patients with epidermal and sebaceous nevi were taken up for this study in all the patients, a detailed clinical history including the duration of the lesion(s), evolution, symptoms if any, and the previous therapeutic modalities used, if any, were recorded. A thorough clinical examination of the lesions including the examination of the old injury scar, BCG scar etc, to look for the keloids/hypertrophic scars was performed. The diagnosis in each patient was made purely on the basis of clinical features. The patients with tendency to develop hypertrophic scars/keloids and with history of bleeding disorders were excluded from with diluted savlon and normal saline and anaesthetized with 2% lignocaine. The surgical laser system used was model C-40 unit, an indigenous carbon dioxide laser apparatus developed by Centre for Advanced Technology, Department of Atomic Energy, Indore, India. It employs Carbon dioxide, Nitrogen and Helium (1: 2.5: 12) gases to produce 10600 nm wavelength beam energy. The lesions were vaporized using a power setting of 10-20 watts delivered in continuous defocussed mode. The charred surface after laser ablation was cleaned with 3% hydrogen peroxide or saline. Topical antibiotic cream was used in all the patients till the laser induced ulcers healed. The patients were evaluated at the end of 1st, 2nd, 4th, 8th and 12th weeks to assess the therapeutic the study. The lesions were thoroughly cleaned response. Post treatment effects like colour changes, itching, pain, infection, scarring, atrophy and recurrence etc. if any, were also recorded. If there was no satisfactory improvement after the initial treatment, subsequent exposures were given.

The final assessment was done at the end of 12 weeks and the overall response was graded as: excellent if it regressed by 75% -100%, good if it was 50%-75% and poor if the improvement was less than 50%. The patients were then followed up every month for 6 months to look for any recurrence.


The present study had 8 patients, 2 males and 6 females between 10-12 years in age. Four patients had asymptomatic epidermal naevi over the extremities, neck and trunk since less than one year of age. Three of these patients had excellent improvement while 1 patient with thick verrucous lesion responded poorly. Four patients had sebaceous nevi lesions over the forehead [Figure - 1], face and left preauricular area since birth. The lesions were asymptomatic in all the patients. At 12th week of treatment, there was very good improvement in 3 [Figure - 2] and good in 1 patient, though 2 of them had mild recurrence at the periphery after 8 weeks of therapy. Transient hypopigmentation of the treated site was seen in all the patients which healed in 3-4 months in all the patients.


Various therapeutic modalities available for treatment of epidermal and sebaceous nevi are either partially effective, insufficient, cosmetically unacceptable or unapplicable particularly for large lesions. Carbon dioxide laser has been effectively used in many such situations with goods results.[1] In this study, 8 patients with epidermal and sebaceous nevi were treated on an outpatient basis with continuous wave defocussed mode CO2 laser using an irradiance of 320 watts/cm2 to 63,700 watts/ cm2. Out of 4 patients with epidermal nevi, 3 showed excellent (80-90%) improvement while 1 had poor (30%) response. The poor response in one patient could be due to very thick lesion where adequate removal could not be done in one sitting and the patient did not agree for subsequent exposures. Carbon dioxide laser has been found to be very effective in these nevi by other workers also.[3],[4],[5] Three out of 4 patients with sebaceous nevi showed excellent (90%) improvement as reported by other workers.[6] One patient with a thicker "U" shaped lesion also had good (60%) improvement. Mild recurrence at the periphery was seen in 2 patients after 8 weeks of therapy. We had a follow-up of 6 months only therefore, recurrences on a longterm follow-up and in a larger group of patients needs to be evaluated. In conclusion C02 laser seems to be a good therapeutic tool for treatment of epidermal and sebaceous nevi. However more experience is required to get better therapeutic outcome.

McBurney El. Carbondioxide laser treatment of dermatologic lesions. South Med J 1978;71:795-797.
[Google Scholar]
Nelson SJ. Lasers: State of art in dermatology. Dermatol Clin 1993;11:15-26.
[Google Scholar]
Hohenleutner U, Wlotzke U, Konz B, et al. Carbondioxide laser therapy of a widespread epidermal nevus. Lasers Surg Med 1995;16: 288-291.
[Google Scholar]
Hohenleutner U, Landthaler M. Laser therapy of verrucous epidermal naevi. Clin Exp Dermatol 1993;18:124-127.
[Google Scholar]
Ratz JL, Bailin PL, Wheland RG. Carbon dioxide laser of epidermal nevi. J Dermatol Surg Oncol 1986;12: 567-570.
[Google Scholar]
Ashinoff R. Linear nevus sebaceus of Jadassohn treated with the carbondioxide laser. Pediatr Dermatol 1993;10:189-191.
[Google Scholar]
Show Sections