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Epidermolysis bullosa pruriginosa
Dept. of Skin & STD, JSS Hospital, Mysore, Karnataka
|How to cite this article:
Veeranna S. Epidermolysis bullosa pruriginosa. Indian J Dermatol Venereol Leprol 2001;67:220
To the Editor,
I read with interest the case report of EB pruriginosa in the issue of Sept-Oct 2000 IJDVL. I would like to express my views regarding this.
1) EBD is a genetically mediated disorder. The authors do not mention about family history in case 1.
2) EBD is inherited as AR or AD. The authors do not mention the mode of inheritance in any of the 3 cases.
3) Pemphigoid nodularis also presents with itchy nodules in presence or absence of blisters. Milia can also be seen in bullous pemphigoid and EB acquisita.
4) Standard immunofluourescence is negative in EB. Using antibodies to known antigens present in the BMZ, antigen mapping can be done by IF to determine the level of blistering in EB. The authors never mention the necessity of IF study.
5) Serum IgE is found increased in several cases of EB pruriginosa. There is no mention about IgE in any of the cases.
The criteria for the diagnosis in the original article was electron microscopic study which we understand is not easily available in our country.The authors rely only on clinical features which can also be seen in nodular pemphigoid and epidermolysis bullosa acquisita.