Generic selectors
Exact matches only
Search in title
Search in content
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obervation Letter
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Special Article
Specialty Interface
Studies
Study Letter
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Tables
Technology
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
View Point
Viewpoint
What’s new in Dermatology
View/Download PDF
Letter To Editor
2004:70:5;316-317
PMID: 17642650

Extrusion of sebaceous gland into a blister of pemphigus vulgaris: An unusual processing artifact

Rajiv Joshi, HS Marwah
 Hinduja Hospital, Mumbai, India

Correspondence Address:
Rajiv Joshi
14, Jay Mahal, 'A' Road, Churchgate, Mumbai - 400 020
India
How to cite this article:
Joshi R, Marwah H S. Extrusion of sebaceous gland into a blister of pemphigus vulgaris: An unusual processing artifact. Indian J Dermatol Venereol Leprol 2004;70:316-317
Copyright: (C)2004 Indian Journal of Dermatology, Venereology, and Leprology

Sir,

Extrusion of sebaceous glands through the follicular canal onto the skin surface is a well known phenomenon first described by Pinkus and Mehrgan.[1] Transfollicular sebaceous gland extrusion is explained as an artifact caused by damage to the fragile sebaceous gland by the effects of the physico-chemical changes that occur during tissue processing and the squeezing effect of the microtome knife as it slices through the paraffin block containing the biopsy tissue, pushing up the dislodged sebaceous gland outward through the common folliculo-sebaceous conduit.

Some authors have expressed reservations about it being an artifact, proposing instead that it be considered a natural phenomenon.[2] Sebaceous glands are found either totally extruded onto the skin surface, or may be seen in a subcorneal location.

We report an unusual location of sebaceous gland extrusion, namely, within the suprabasal blister of pemphigus vulgaris.

A 34 year old male presented to one of us (HSM), with a one year history of multiple fluid filled blisters all over the body. He had earlier received short courses of oral steroids in the dose of about 15-20 mg prednisolone per day with partial clearing of the blisters. However, on discontinuing the steroids, he had developed extensive relapse with numerous small flaccid vesicles appearing on normal looking skin. Oral lesions had been present on and off, but no oral involvement was present at the time of this presentation. A clinical diagnosis of pemphigus was considered and a biopsy that included one of the new vesicles was obtained from the right side of the upper back.

Sections from the biopsy showed a small suprabasal blister with an intact sebaceous lobule occupying the cavity of the blister. [Figure - 1] This structure was identified as a sebaceous lobule as it was made up of typical mature sebocytes with central scalloped nuclei and abundant vacuolated cytoplasm. A few acantholytic cells were seen in the blister, but no inflammation or other blisters were seen in the section. Serial sections taken through the block revealed in the mid dermis a folliculo-sebaceous structure that showed suprabasal clefts with acantholysis in follicular and sebaceous epithelium, findings consistent with pemphigus vulgaris.

In sum, we report an unusual histopathological finding of extrusion of sebaceous gland into the blister cavity of pemphigus vulgaris. The acantholytic process in the lesion biopsied in our patient appears to affect the folliculo-sebaceous epithelium leading to sebaceous gland extrusion into an acantholytic suprabasal blister within the epidermis.

References
1.
Mehregan AH, Alberta E, Pinkus H. Artifacts in dermatohistopathology. Arch Dermatol 1966;94:218-25.
[Google Scholar]
2.
Weigand DA. Transfollicular extrusion of sebaceous glands: Natural phenomenon or artifact? A case report. J Cutan Pathol 1976;3:239-44.
[Google Scholar]

Fulltext Views
129

PDF downloads
17
Show Sections