Translate this page into:
Giant cutaneous metastasis of gastric signet ring cell carcinoma
Corresponding author: Dr. Hao Chen, Department of Dermatopathology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu, China. ch76ch@163.com
-
Received: ,
Accepted: ,
How to cite this article: Chen R, Chen H. Giant cutaneous metastasis of gastric signet ring cell carcinoma. Indian J Dermatol Venereol Leprol. doi: 10.25259/IJDVL_811_2025
A 68-year-old man with a history of gastric adenocarcinoma presented with a rapidly enlarging cutaneous mass over the past month. Physical examination revealed a giant violaceous tumour with well-defined borders on the neck and back [Figure 1]. Histopathological examination revealed diffuse infiltration of tumour cells with characteristic signet-ring morphology in the dermis [Figure 2]. Tumour cells were positive for CK, CK5/6, CK18, Claudin-18.2, and CDX2 [Figure S1]. Immunohistochemistry confirmed cutaneous metastasis of gastric signet-ring cell carcinoma. Post-chemotherapy, the tumour decreased in size. Giant cutaneous metastasis of the gastric signet-ring cell carcinoma, an exceedingly rare manifestation, is associated with advanced-stage cancer and an extremely poor prognosis. Clinicians should maintain a high degree of suspicion for atypical skin lesions that occur in patients with a history of malignant tumours.
- Cutaneous mass on the upper back.
![Diffuse infiltration of tumour cells with characteristic signet ring appearance (black arrowhead) in the dermis. Haematoxylin and eosin, 200x, (inset- 400x)]](/content/126/2025/0/1/img/IJDVL_811_2025-g2.png)
- Diffuse infiltration of tumour cells with characteristic signet ring appearance (black arrowhead) in the dermis. Haematoxylin and eosin, 200x, (inset- 400x)]
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent.
Financial support and sponsorship
Nil.
Conflicts of interest
There are no conflicts of interest.
Use of artificial intelligence (AI)-assisted technology for manuscript preparation
The authors confirm that there was no use of artificial intelligence (AI)-assisted technology for assisting in the writing or editing of the manuscript and no images were manipulated using AI.