Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current Issue
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
Images in Dermatology
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Media and news
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Images
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Reviewers 2022
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Snippets
Special Article
Specialty Interface
Studies
Study Letter
Study Letters
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Systematic Review and Meta-Analysis
Systematic Reviews and Meta-analyses
Systematic Reviews and Meta-analysis
Tables
Technology
Therapeutic Guideline-IADVL
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
Therapy Letters
View Point
Viewpoint
What’s new in Dermatology
Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current Issue
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
Images in Dermatology
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Media and news
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Images
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Reviewers 2022
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Snippets
Special Article
Specialty Interface
Studies
Study Letter
Study Letters
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Systematic Review and Meta-Analysis
Systematic Reviews and Meta-analyses
Systematic Reviews and Meta-analysis
Tables
Technology
Therapeutic Guideline-IADVL
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
Therapy Letters
View Point
Viewpoint
What’s new in Dermatology
View/Download PDF

Translate this page into:

Case Report
2003:69:4;292-293
PMID: 17642916

Greither’s disease

SB Athanikar, AC Inamadar, A Palit, VV Sampagavi, NS Deshmukh
 Departments of Dermatology, Venereology & Leprology, BLDEA’s SBMP Medical College, Hospital & Research Centre, Bijapur, India

Correspondence Address:
A C Inamadar
Department of Dermatology, Venereology & Leprology, BLDEA’s SBMP Medical College, Hospital & Research Centre, Bijapur - 586103
India
How to cite this article:
Athanikar S B, Inamadar A C, Palit A, Sampagavi V V, Deshmukh N S. Greither’s disease . Indian J Dermatol Venereol Leprol 2003;69:292-293
Copyright: (C)2003 Indian Journal of Dermatology, Venereology, and Leprology

Abstract

A 14-year-old girl with diffuse palmoplantar keratoderma with hyperhidrosis and progressive extension of keratoderma to the dorsum of the hands and feet is reported. The inheritance pattern was autosomal dominant.
Keywords: Greither's disease, Palmoplantar keratoderma
Introduction

Hereditary palmoplantar keratodermas (PPK) are a heterogeneous group of diseases characterized by hyperkeratosis of the palms and soles with thickening of the stratum corneum, usually distinguishable by the mode of inheritance and by associated clinical findings.[1] We report a case of diffuse palmoplantar keratoderma associated with hyperhidrosis and progressive extension of the keratoderma to the dorsa of the hands and feet.

Case report

A 14-year-old girl presented to the dermatology OPD with the complaint of thickening of the palms and soles since the age of 6 years. Initially, thickening was noted in the centre of the palms and soles, and gradually spread to the periphery. Thickened skin was also noted over the knees and just below the lower lip. She was born of a non-consanguinous marriage. There was a history of her paternal grandfather and father suffering from a similar illness. The patient had three siblings of whom one sister had a similar ailment.

Cutaneous examination revealed diffuse palmoplantar keratoderma with hyperhidrosis [Figure - 1]. An erythematous border was found around the keratoderma [Figure - 2] that continued along the Achilles tendon. The knee and the area just below the upper lip exhibited hyperkeratotic plaques. Routine hematological and urine examination findings were within normal limits. The patient refused a biopsy. A clinical diagnosis of Griether′s disease was made.

Discussion

Greither first described this disorder in 1952.[1] The most important signs and symptoms[2] are diffuse PPK with an erythematous border. The lesions tend to extend to the dorsum of the hands and feet (transgradiens), and hyperkeratotic plaques are present on the elbows and knees. Marked hyperhidrosis is said to be typical of this condition.

The nosological situation of this keratoderma is under scrutiny since the publication of Greither.[3] Some consider it as a distinct entity, while others consider it as a variant of the Unna-Thost type of PPK.[4] It is claimed to differ from the Unna-Thost variety by showing extension to the extensor surface of the hands, knees and elbows and by showing a tendency to improve in the fifth decade.[5] Greither′s disease has several clinical similarities with Mal de Meleda syndrome.[6] However, in contrast to Mal de Meleda syndrome, the palms and soles may be spared in Greither′s disease. Mal de Meleda syndrome is autosomal recessive; PPK appears early after birth and progressively involves other regions of the body without a tendency for spontaneous involution. It also has typical nail changes.

To conclude, we report a case of PPK consistent with the clinical and genetic definitions of Greither′s disease. The histology described by Greither and others is not specific.[1] We think that the natural history and the unique clinical findings justify retaining the entity as Griether′s disease. An electron microscopic study by Beylot-Barry et al[7] showed aggregated tonofilaments around the nucleus, without true clump formation. Desmosomes were numerous and cell-cell junctions showed an imbricated pattern. Molecular genetic investigation with localization of the responsible gene may clarify the nosologic situation of this type of keratoderma.

References
1.
Greither A. Keratosis extremitatum hereditaria progrediens mit dominantem Erogang. Hautarzt 1952;3:198-203. Quoted from Kansky A, Arzensek J. Is palmoplantar keratoderma of Greither's type a separate nosologic entity? Dermatologica 1979;158:244-8.
[Google Scholar]
2.
Fluckiger R, Itin PH. Keratosis extremitatum (Greither's disease): Clinical features, histology, ultrastructure. Dermatology 1993;187:309-11.
[Google Scholar]
3.
Kansky A, Arzensek J. Is palmoplantar keratoderma of Greither's type a separate nosologic entity? Dermatologica 1979;158:244-8.
[Google Scholar]
4.
Goldsmith LA. In: Moschella SL, Hurley HJ, editors. Dermatology. 2nd ed. Philadelphia: WB Saunders; 1985. p. 1256-7.
[Google Scholar]
5.
Griffiths WAD, Judge MR, Leigh IM. In: Champion RH, Burton JL, Burns DA, Breathnach SM, editors. Textbook of dermatology. 6th ed. London: Blackwell Science; 1998. p. 1557-62.
[Google Scholar]
6.
Lestingant GG, Hadi SM, Qayed KI, Blayney BJ. Mal de Meleda: Recessive transgressive palmoplantar keratoderma with three unusual facultative features. Dermatology 1992;184:72-82.
[Google Scholar]
7.
Beylot-Barry M, Taieb A, Surleve-Bazeille JE, Malevitte J. Inflammatory familial palmoplantar keratoderma: Greither's disease? Dermatology 1992;185:210-4.
[Google Scholar]

Fulltext Views
4,605

PDF downloads
811
Show Sections