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Letter To Editor
2008:74:4;396-397
doi: 10.4103/0378-6323.42920
PMID: 18797074

Hydroxychloroquine versus chloroquine in polymorphic light eruption

Gurcharan Singh, G Archana
 Department of Dermatology and STD, Sri Devaraj Urs Medical College, Tamaka, Kolar-563 101, India

Correspondence Address:
Gurcharan Singh
108, A, Jal Vayu Vihar, Kamanahalli, Bangalore-560 043
India
How to cite this article:
Singh G, Archana G. Hydroxychloroquine versus chloroquine in polymorphic light eruption. Indian J Dermatol Venereol Leprol 2008;74:396-397
Copyright: (C)2008 Indian Journal of Dermatology, Venereology, and Leprology

Sir,

We read the article titled "Comparative study of efficacy and safety of hydroxychloroquine and chloroquine in polymorphic light eruption: A randomized, double-blind, multicentric study" with great interest. However, we wish to point out the following incongruities observed in this study.

The conclusion drawn about superior efficacy and tolerability of hydroxychloroquine over chloroquine is not corroborated by the findings of the study, where only a marginal difference was observed in the efficacy of the two drugs, and in fact, chloroquine fared better in the side effect profile. [1]

Negative serological tests for light eruption (LE) are pertinent and desirable for the diagnosis of polymorphic light eruption (PLE) patients as PLE and LE may often coexist and PLE precedes LE in a subset of the patients. [2],[3]

The lack of ocular toxicity observed in the hydroxychloroquine treatment group after a short course of therapy is understandable as the same is expected after long-term use only. The important risk factors for ocular toxicity associated with hydroxychloroquine therapy are: excessive daily dosage, increasing cumulative dosage, the duration of treatment and the patient′s age as well as coexistent renal or liver disease and concomitant retinal disease. [4],[5]

References
1.
Pareek A, Khopkar U, Sacchidanand S, Chandurkar N, Naik GS. Comparative study of efficacy and safety of hydroxychloroquine and chloroquine in polymorphic light eruption: A randomized, double-blind, multicentric study. Indian J Dermatol Venereol Leprol 2008;74:18-22.
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2.
Nyberg F, Hasan T, Puska P, Stephansson E, Hδkkinen M, Ranki A, et al . Occurrence of polymorphous light eruption in lupus erythematosus. Br J Dermatol 1997;136:217-21.
[Google Scholar]
3.
Murphy GM, Hawk JL.The prevalence of antinuclear antibodies in patients with apparent polymorphic light eruption. Br J Dermatol 1991;125:448-51.
[Google Scholar]
4.
Yam JC, Kwok AK. Ocular toxicity of hydroxychloroquine. Hong Kong Med J 2006;12:294-304.
[Google Scholar]
5.
Jones. SK Ocular toxicity and hydroxychloroquine: Guidelines for screening. Br J Dermatol 1999;140:3-7.
[Google Scholar]

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