Linear IgA bullous dermatosis induced by diclofenac sodium
Department of Dermatology and S T D, Lady Hardinge Medical College and Associated Hospitals, Shaheed Bhagat Singh Marg, New Delhi - 110 001
|How to cite this article:
Sanke S, Kumar A, Chander R. Linear IgA bullous dermatosis induced by diclofenac sodium. Indian J Dermatol Venereol Leprol 2018;84:496-497
An 18-year-old female presented with multiple, fluid-filled lesions all over the body of 5 days duration, which was preceded by intake of oral diclofenac 100mg for leg pain 3 days prior to the development of lesions. Cutaneous examination showed multiple, clear, fluid-filled as well as hemorrhagic vesicles and bullae all over the body ranging from 0.5 cm to 4 cm in diameter forming a “string of pearl” configuration [Figure - 1]. All mucosae were normal. Nikolsky's sign and bulla spread sign were negative. Histopathology from a fresh vesicle showed subepidermal blister with perivascular and interstitial inflammatory infiltrate composed of neutrophils and eosinophils.. Direct immunofluorescence from the perilesional skin revealed linear deposition of IgA along the dermo-epidermal junction. The Naranjo score for adverse drug reaction was 7 (probable drug reaction). In the absence of any other precipitating factors, constitutional features, and normal laboratory findings, a diagnosis of linear IgA bullous disease induced by diclofenac sodium was made.
|Figure 1: Multiple clear to hemorrhagic fluid-filled bullae in a “string of pearl” configuration|
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