Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Art & Psychiatry
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Conference Oration
Conference Summary
Continuing Medical Education
Cosmetic Dermatology
Current Best Evidence
Current Issue
Current View
Derma Quest
Dermato Surgery
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
Editor Speaks
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
In Memorium
Inaugural Address
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Medicolegal Window
Miscellaneous Letter
Net Case
Net case report
Net Image
Net Letter
Net Quiz
Net Study
New Preparations
News & Views
Observation Letter
Observation Letters
Original Article
Original Contributions
Pattern of Skin Diseases
Pediatric Dermatology
Pediatric Rounds
Presedential Address
Presidential Address
Presidents Remarks
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Review Article
Review Articles
Reviewers 2022
Revision Corner
Self Assessment Programme
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Special Article
Specialty Interface
Study Letter
Study Letters
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Systematic Review and Meta-Analysis
Systematic Reviews and Meta-analyses
Systematic Reviews and Meta-analysis
Therapeutic Guideline-IADVL
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapy Letter
Therapy Letters
View Point
What’s new in Dermatology
View/Download PDF

Translate this page into:

Study Letter
88 (
); 114-116

Methylprednisolone pulse therapy for leprosy neuritis: A retrospective study with sensory testing and peripheral nerve ultrasonography correlation

Department of Internal Medicine, Division of Dermatology, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil
Department of Medical Imaging, Hematology and Clinical Oncology, Division of Radiology, Ribeirão Preto Medical School, University of São Paulo Ribeirão Preto, São Paulo, Brazil
National Reference Center in Sanitary Dermatology focused on Leprosy of Ribeirão Preto Clinical Hospital (CRNDSHansen), Brazil
Corresponding author: Dr. Helena B. Lugão, Av. Bandeirantes, 3900, Campus Universitário, Ribeirão Preto, São Paulo, Brazil.

Read ERRATUM associated with this - 10.25259/IJDVL_1280_20_ER

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

How to cite this article: Lugão HB, Savarese LG, Silva SR, Barbosa MH, Foss NT, Frade MA. Methylprednisolone pulse therapy for leprosy neuritis: A retrospective study with sensory testing and peripheral nerve ultrasonography correlation. Indian J Dermatol Venereol Leprol 2022;88:114-6.


Patients with leprosy neuritis are more likely to have disability. Nerve ultrasonography (USG) is inexpensive, widely available and can aid diagnosis and follow-up of neuritis.1-3 Oral steroids are the mainstay of treatment of neuritis. Pulsed intravenous corticosteroids may be used for severe neuritis, recalcitrant neuritis or for patients suffering from neuritis who have contraindications for oral steroids.4

We retrospectively reviewed data from 21 leprosy patients with neuritis, treated with pulse therapy at the National Reference Centre in Sanitary Dermatology Focusing on Leprosy of Ribeirão Preto Clinical Hospital – Brazil [Table 1]. Records of patients suffering from hypothyroidism, HIV infection, traumatic and hereditary neuropathies were not reviewed. Four diabetic patients were included in the study.

Table 1:: Clinical data of the patients included
Age range (years) 12–63
Mean±SD 49.95±12.06
Sex n(%)
Male 17 (81%)
Female 4 (19%)
Leprosy classification n(%)
Borderline-tuberculoid 2 (9.5%)
Borderline-borderline 4 (19%)
Borderline-lepromatous 6 (28.6%)
Lepromatous 4 (19%)
Primary neural leprosy 5 (23.8%)
Slit skin smear n(%)
Positive 10 (47.6%)
Negative 11 (52.4%)
Leprosy reaction* n(%)
Isolated neuritis 10 (47.6%)
Type 1 6 (28.6%)
Type 2 8 (38.1%)
Multidrug Therapy n(%)
Pulses were done during MDT 15 (71.4%)
Pulses were done after MDT 6 (28.6%)
Anti-reaction treatment before pulse-therapy
Pulse was initial anti-reaction treatment 5 (23.8%)
Prednisone 10 (47.6%)
Months of prednisone use before pulses: range (mean±SD) 2–29 (10±8.25)
Prednisone + thalidomide 6 (28.6%)
Months of prednisone use before pulses: range (mean±SD) 17–72 (41±17.91)
All 21 patients had neuritis, three patients had both types 1 and 2 reactions associated with neuritis. n: Number of patients, SD: Standard deviation, MDT: Multidrug therapy

The patients had received intravenous methylprednisolone 1 g/day for three days in the first pulse and 1 g/day for one day in the subsequent pulses.4 The interval between pulses was approximately one month; all patients received at least one cycle, consisting of three pulses. Four patients needed another cycle 6–33 months after the first one due to recurrent neuritis; therefore, data from 25 cycles were analysed. The patients underwent skin and neurological examination monthly; prednisone and thalidomide doses were individually tailored according to clinical response.

Sensory testing using Semmes-Weinstein monofilaments (0.05 g, 0.2 g, 2 g, 4 g, 10 g and 300 g; 7 points on each hand and 10 points on each foot) was performed before and after each pulse therapy cycle. Poor sensory testing outcome was defined as significant worsening (≥2 monofilament grades) in more than 20% of hands or feet points.

All patients underwent peripheral nerve ultrasonography before and after each cycle of pulse therapy. The ulnar nerve (proximal to the cubital tunnel and at the cubital tunnel), median nerve and common fibular nerve were scanned along their transverse and longitudinal axes.3 Poor cross-sectional areas outcomes were defined elsewhere.3 Intraneural or epineural arterial blood flow pattern detected by color/ power Doppler (pulse repetition frequency 0.7–1 kHz) was considered indicative of nerve hypervascularity.

Statistical analysis included Wilcoxon, Fisher and McNemar tests and Spearman coefficients. We considered p value< 0.05 as statistically significant.

Adjuvant treatment given pre- and post-pulse is shown in Table 2. Most patients had their prednisone (14/16, 87.5%) and thalidomide (5/6, 83.3%) doses reduced after pulses. Eight patients discontinued prednisone use within six months. No patient had major adverse events.

Table 2:: Pre- and post-pulse prednisone and thalidomide doses
Prednisone (n=16) Pre-pulse Post-pulse*
Minimum dose 40 mg zero
Maximum dose 80 mg 30 mg
Median 60 mg 10 mg
Mean (mg/kg/day) 0.76 0.17
Mean±SD 58±12.4 mg 13.1±10.8 mg <0.0001
Thalidomide (n=6) Pre-pulse Post-pulse*
Minimum dose 100 mg zero
Maximum dose 200 mg 200 mg
Median 200 mg 100 mg
Mean±SD 183±40.8 mg 100±63.3 mg p=0.004
Three months after the last pulse, Statistically significant. n: Number of patients, SD: Standard deviation

Table 3 shows sensory testing data. Only six patients (28.6%) had poor sensory outcomes. Patients with type 2 reactions had a higher frequency of poor sensory outcomes (5/11 pulse therapy cycles, 45.5%) compared to patients with isolated neuritis (3/11 cycles, 27.3%) and type 1 reactions (2/7 cycles, 28.6%) (p > 0.05 for all comparisons).

Table 3:: Frequency of abnormal sensory testing points and grade 1 disability
Pre-pulse Post-Pulse P-value
Abnormal sensory testing points*
Hands 53.9% (187/347) 47.7% (167/350) >0.05
Feet 55.4% (276/498) 48.1% (239/497) >0.05
Patients with grade 1 disability†
Hands 14/21 13/21 >0.05
Feet 17/21 15/21 >0.05
Not feel a 0.2 g monofilament on hand points and a 2 g monofilament on foot points, Not feel a 2 g monofilament on any hand or foot point

There were no significant differences between pre- and post-pulse cross-sectional areas for any nerve. The frequencies of poor cross-sectional area outcomes were: 30/50 for ulnar nerve proximal to the cubital tunnel (60), 21/50 for ulnar nerve at cubital tunnel (42%), 23/50 for the median nerve (46%) and 29/48 for the common fibular nerve (60.4%). Figure 1 shows the frequencies of poor cross-sectional area outcomes in patients with isolated neuritis, type 1 and type 2 reactions. The frequency of nerves with positive Doppler signal decreased after pulses (65/198, 32.8% pre-pulse and 35/198 and 17.7% post-pulse; p = 0.0004). Pre-pulse positive Doppler signal was significantly associated with poor cross-sectional area outcome in ulnar nerves proximal to cubital tunnel and median nerves.

Figure 1:: Frequency of poor cross-sectional area outcomes for patients with isolated neuritis, type 1 and type 2 reactions

Sensory testing and ultrasonography results were not significantly different between patients with positive or negative slit-skin smears and between patients with or without diabetes. There was no correlation between poor sensory and poor cross-sectional area outcomes for the studied nerves.

This is the first study investigating ultrasonography findings and their correlation with sensory testing in leprosy neuritis treated with pulse therapy. Despite the severity of nerve involvement of our patients, we found that pulse was effective in preserving nerve function. In addition, it allowed prednisone dose reduction/withdrawal even in patients with chronic steroid use before pulses. As expected, ultrasonography findings showed that pulse therapy was not effective in improving nerve enlargement, which may persist despite antibacterial and anti-reaction treatments.3 However, it reduced hypervascularity/ inflammation as detected by Doppler signal.

The only randomised controlled double blind trial comparing pulse therapy and oral steroids showed better sensory testing results in the pulse group at day 29 after infusion but no beneficial effect by day 337.5 In that trial, patients received a single pulse, without subsequent monthly infusions, likely hindering the potential benefit. Further, approximately 20% of the patients in that sample did not have nerve function impairment,5 while we only included patients with severe and/or recalcitrant neuritis.

The sample size and retrospective design are drawbacks of our study. Although diabetic neuropathy could be a confounding factor, results did not differ significantly between the patients with and without diabetes. Pulse therapy may be an interesting option for neuritis treatment in diabetic patients, allowing for smaller daily steroid doses, thus contributing to better metabolic control.

In conclusion, pulse therapy was effective in preserving sensibility and allowing reduction of oral steroid doses. Nerve ultrasonography can be an adjuvant tool for monitoring the inflammatory process in leprosy neuritis.

Declaration of patient consent

Institutional Review Board (IRB) permission obtained for the study.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.


  1. , , , , , . New sonographic measures of peripheral nerves: A tool for the diagnosis of peripheral nerve involvement in leprosy. Mem Inst Oswaldo Cruz. 2013;108:257-62.
    [CrossRef] [PubMed] [Google Scholar]
  2. , , , , . Asymmetric nerve enlargement: A characteristic of leprosy neuropathy demonstrated by ultrasonography. PLoS Negl Trop Dis. 2015;9:e0004276.
    [CrossRef] [PubMed] [Google Scholar]
  3. , , , , . Ultrasonography of leprosy neuropathy: A longitudinal prospective study. PLoS Negl Trop Dis. 2016;10:e0005111.
    [CrossRef] [PubMed] [Google Scholar]
  4. . Diretrizes Para Vigilância, Atenção e Eliminação da Hanseníase Como Problema de Saúde Pública: Manual Técnico-operacional. . Ministério da Saúde, Brasília, DF, Brazil. Available from: [Last accessed on 2021 Jun 20]
    [Google Scholar]
  5. , , , , , , et al. A phase two randomised controlled double blind trial of high dose intravenous methylprednisolone and oral prednisolone versus intravenous normal saline and oral prednisolone in individuals with leprosy Type 1 reactions and/or nerve function impairment. PLoS Negl Trop Dis. 2011;5:e1041.
    [CrossRef] [PubMed] [Google Scholar]

Fulltext Views

PDF downloads
View/Download PDF
Download Citations
Show Sections