Generic selectors
Exact matches only
Search in title
Search in content
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obervation Letter
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Special Article
Specialty Interface
Studies
Study Letter
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Tables
Technology
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
View Point
Viewpoint
What’s new in Dermatology
Case Report
2002:68:2;108-109
PMID: 17656900

Metronidazole causing fixed drug eruption

SK Arora
 Department of Skin VD and Leprosy, G.S.V.M Medical College, Kanpur, India

Correspondence Address:
S K Arora
L-17, Medical College Campus Kanpur-208 002
India
How to cite this article:
Arora S K. Metronidazole causing fixed drug eruption. Indian J Dermatol Venereol Leprol 2002;68:108-109
Copyright: (C)2002 Indian Journal of Dermatology, Venereology, and Leprology

Abstract

A rare case of fixed drug eruption due to metronidazole is reported.
Keywords: Drug eruption, Fixed drug eruption, Metronidozole

Introduction

Fixed drug eruption is a common type of drug eruption seen in skin clinics. Causative drugs[1] are sulphonamides, salicylates, oxyphenbutazones, tetracycline, dapsone, chlordia zepoxide, barbiturates, phenolphtheline, morphine, codiene, quinine and derivatives , phenacetin, erythromycin , griseofulvin, mebendazole, meprobamate etc. Many drugs such as dapsone, griseofulvin, erythromycin etc, are commonly used but FDE occurs rarely.

Metronidazole is another drug which is being used commonly but FDE occurs very rarely so much so, in books it is not mentioned in the list of causative drugs.

Case Report

A 59 - year - old male patient, doctor by profession reported with itching over penis for three days. On examination there was redness and oozing on the inner aspect of prepuce and along the coronal sulcus. There was no pus discharge. He was nondiabetic and he denied history of extramarital exposure. He was taking metronidazole for last 7 days. No other drug was taken by him during this period. The patient was given local steroids and antihistaminic. Lesion healed in 4 days time. Metronidazole 200 mg was given for provocation test after 7 days which did not give any reaction. Again 400mg of metronidazole was given which caused reactivation of lesion in the form of redness and itching.

Discussion

Metronidazole is a commonly used drug due to wide prevalence of amoebiasis in India but fixed drug eruption due to it , is rare. Naik and Singh[3] in 1977 reported fixed drug eruption due to metronidazole on the back of a patient who was taking this drug very frequently. In our case FDE appeared on penis, which is a common site[1] and was confirmed by provocation test. Special feature was provocation only by full dose of the drug.

References
1.
Bilimoria FE, Shah PP Drug reactions. In: IADVL Textbook and Atlas of Dermatology, Edited by Valia RG, Bhalani Publishing House, Bombay 1994;1139.
[Google Scholar]
2.
Naik RPC, Singh G. Bullous fixed drug eruption presumably due to erythromycin. Dermatologica 1976;152:177-180.
[Google Scholar]
3.
Naik RPC, Singh G. Fixed drug eruption due to metronidazole. Dermatologica 1977;155:59-61.
[Google Scholar]
Show Sections