How to cite this article: Hazarika N, Maisnam S, Azad S. Mucosal syphilide. Indian J Dermatol Venereol Leprol doi: 10.25259/IJDVL_391_2023
A man in his twenties presented with painful, whitish, raised lesions inside his mouth and on lips for 7 months. Personal history was positive for unprotected, men-who-have-sex-with-men (MSM) behaviour. Examination revealed whitish to erythematous, hypertrophic tumid plaques on soft palate and lips [Figures 1 and 2]. Histopathology revealed pseudoepitheliomatous hyperplasia with dense dermal plasma cell infiltration. Immunohistochemistry (IHC) was positive for CD-38 and CD-138, and no restriction pattern on Kappa and Lambda. IHC suggested reactive mature plasma cells. Rapid plasma reagin (RPR) test (1:64 dilution), and Treponema pallidum haemaggulitination (TPHA) test were positive. Retrovirus serology was negative. These investigations confirmed the diagnosis of secondary syphilis and the patient was treated with single intramuscular injection of benzathine penicillin 2.4 million international unit (IU).
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