Oral gugulipid in acne vulgaris management

Abstract

Gugulipid is the standardized extract of the oleo-resin of Commiphora mukul (Burseraceace) an Indian medicinal plant. The active ingredients are two guggulsterones Z and E. Gugulipid is an effective hypolipidemic agent, has a marked antilipolytic activity in rats. Considering the pathogenesis of acne vulgaris and the pharmacological properties of Gugulipid this trial was initiated. Thirty patients with moderate to severe acne ( Grade 4) were included in this study. Tab Guglip was prescribed in tds dosage for 6 weeks. Excellent, good and moderate response was seen in nine (30%) fourteen (46.66%) and seven (23.33%) patients respectively out of the total thirty. No topical treatment was recommended except for local skin -hygiene. The drug showed excellent tolerance. Only three patients (10%) reported relapse when examined at 3 months follow up.