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Acne in India: Guidelines for management - IAA Consensus Document
2009:75:7;5-9
PMID: 19282582

Pathogenesis of acne

Raj Kubba, AK Bajaj, DM Thappa, Rajeev Sharma, Maya Vedamurthy, Sandipan Dhar, S Criton, Rui Fernandez, AJ Kanwar, Uday Khopkar, Malavika Kohli, VP Kuriyipe, Koushik Lahiri, Nina Madnani, Deepak Parikh, Sudhir Pujara, KK Rajababu, S Sacchidanand, VK Sharma, Jayakar Thomas
 members Indian Acne Alliance, India

Correspondence Address:
Raj Kubba
Consultant Dermatologist, Kubba Clinic,10, Aradhana Enclave, Ring Road, New Delhi - 110066
India
How to cite this article:
Kubba R, Bajaj A K, Thappa D M, Sharma R, Vedamurthy M, Dhar S, Criton S, Fernandez R, Kanwar A J, Khopkar U, Kohli M, Kuriyipe V P, Lahiri K, Madnani N, Parikh D, Pujara S, Rajababu K K, Sacchidanand S, Sharma V K, Thomas J. Pathogenesis of acne. Indian J Dermatol Venereol Leprol 2009;75:5-9
Copyright: (C)2009 Indian Journal of Dermatology, Venereology, and Leprology
References
1.
Cunliffe WJ, Gollnick HPM. Acne: Diagnosis and management. London: Martin Dunitz; 2001. p. 1-46.
[Google Scholar]
2.
Gollnick H, Cunliffe W, Berson D, Dreno B, Finlay A, Leyden JJ, et al . Management of acne: A report from a global alliance to improve outcomes in acne. J Am Acad Dermatol 2003;49:S1-38.
[Google Scholar]
3.
Knutson DD. Ultrastuctural observations in acne vulgaris: The normal sebaceous follicles and acne lesions. J Invest Dermatol 1974;62:288-307.
[Google Scholar]
4.
Cunliffe WJ, Holland DB, Clark SM, Stables GI. Comedogenesis: Some new aetiological, clinical and therapeutic strategies. Br J Dermatol 2000;142:1084-91.
[Google Scholar]
5.
Plewig G, Fulton JE, Kligman AM. Cellular dynamics of comedo formation in acne vulgaris. Arch Dermatol Forsch 1971;242:12-29.
[Google Scholar]
6.
Kurokawa I, Mayer-da-Silva A, Gollnick H, Orfanos CF. Occurrence and distribution of cytokeratins and filagrin in the human pilosebaceous unit: An immunocytochemical study. In: Marks R, Plewig G, editors. Acne and related disorders. London: Martin Dunitz; 1989. p. 19-22.
[Google Scholar]
7.
Knaggs HE, Holland DB, Morris C, Wood EJ, Cunliffe WJ. Quantification of cellular proliferation in acne using the monoclonal antibody Ki-67. J Invest Dermatol 1994;102:89-92.
[Google Scholar]
8.
Hughes BR, Morris C, Cunliffe WJ, Leigh IM. Keratin expression in pilosebaceous epithelia in truncal skin of acne patients. Br J Dermatol 1996;134:247-56.
[Google Scholar]
9.
Downing DT, Stewart ME, Wertz PW, Strauss JS. Essential fatty acids and acne. J Am Acad Dermatol 1986;14:221-5.
[Google Scholar]
10.
Thibutot DM, Knaggs H, Gilliand K, Hagari S. Activity of type 1 5-a reductase and 17-β -hydroxysteroid dehydrogenase in the infrainfundibulum of subjects with and without acne vulgaris. Dermatology 1998;196:38-42.
[Google Scholar]
11.
Thielitz A, Helmdach M, Roepke EM, Gollnick H. Lipid analysis of follicular casts from cyanoacrylate strips as a new method for studying therapeutic effects of antiacne agents. Br J Dermatol 2001;145:19-27.
[Google Scholar]
12.
Lavker RM, Leyden JJ. Lamellar inclusions in follicular horny cells: A new aspect of abnormal keratinization. J Ultrastruct Res 1979;69:362-70.
[Google Scholar]
13.
Kluznik AR, Wood EJ, Cunliffe WJ. Keratin characterization in the pilosebaceous ducts of acne patients. In: Marks R, Plewig G, editors. Acne and related disorders. London: Martin Dunitz; 1989. p. 113-5.
[Google Scholar]
14.
Ingham E, Eady EA, Goodwin CE. Pro-inflammatory levels of interlukin 1-a like bioactivity are present in the majority of open comedones in acne vulgaris. J Invest Dermatol 1992;98:895-901.
[Google Scholar]
15.
Guy R, Kealey T. Modelling the infundibulum in acne. Dermatology 1998;196:32-7.
[Google Scholar]
16.
Pochi PE, Strauss JS, Downing DT. Age related changes in sebaceous gland activity. J Invest Dermatol 1979;73:108-11.
[Google Scholar]
17.
Pochi PE, Strauss JS. Endocrinologic control of the development and activity of the human sebaceous gland. J Invest Dermatol 1974;62:191-201.
[Google Scholar]
18.
Gollnick HPM, Zouboulis CC, Akamatsu H, Kurokawa I, Schulte A. Pathogenesis and pathogenesis-related treatment of acne. J Dermatol 1991;18:489-99.
[Google Scholar]
19.
Pochi PE, Strauss JS. Sebum production, casual sebum levels, titrable acidity of sebum and urinary fractional 17-ketosteroid excretion in males with acne. J Invest Dermatol 1964;43:383-8.
[Google Scholar]
20.
Burton JL, Shuster S. The relationship between seborrhea and acne vulgaris. Br J Dermatol 1971;84:600-1.
[Google Scholar]
21.
Cunliffe WJ, Shuster S. Pathogenesis of acne. Lancet 1969;1:685-7.
[Google Scholar]
22.
Thibutot D, Harris G, Iles V, Cimis G, Gilliland K, Hagari S. Activity of the type 1 5-alpha-reductase exhibits regional differences in isolated sebaceous glands and whole skin. J Invest Dermatol 1995;105:209-14.
[Google Scholar]
23.
Thibutot D, Knaggs H, Gilliand H, Lin G. Activity of 5-a-reductase and 17-β -hydroxysteroid dehydrogenase in the infrainfundibulum of subjects with and without acne vulgaris. Dermatology 1998;196:38-42.
[Google Scholar]
24.
Chen W, Zouboulis CC, Fritsch M, Kodelja V, Orfanos CE. Heterogeneity and quantitative differences of type 1 5-a-reductase expression in cultured skin epithelial cells. Dermatology 1998;196:51-2.
[Google Scholar]
25.
Fritsch M, Orfanos CE, Zouboulis CC. Sebocytes are the key regulators of androgen homeostasis in human skin. J Invest Dermatol 2001;116:793-800.
[Google Scholar]
26.
Leyden JJ. New understandings of the pathogenesis of acne. J Am Acad Dermatol 1995;32:S15-25.
[Google Scholar]
27.
Schmidt JB, Spona J, Huber J. Androgen receptor in hirsutism and acne. Gynecol Obstet Invest 1986;22:206-11.
[Google Scholar]
28.
Deplewski D, Rosenfield RL. Role of hormones in pilosebaceous unit development. Endocrine Rev 2000;21:363-92.
[Google Scholar]
29.
Akamatsu H, Zouboulis CC, Orfanos CE. Control of human sebocyte poriliferation in vitro by testosterone and 5-a-dihydrotestosterone is dependent on the localization of the sebaceous gland. J Invest Dermatol 1992;99:509-11.
[Google Scholar]
30.
Habif TP. Acne, rosacea, and related disorders, In: Habif TP, editor, Clinical dermatology: A color guide to diagnosis and therapy. 4 th ed. Edinburgh: Mosby; 2004. p. 168-70.
[Google Scholar]
31.
Auffret N. What's new concerning the pathophysiology of acne? Ann Dermatol Venereol 2003;130:101-6.
[Google Scholar]
32.
Leyden JJ, McGinley KJ, Mills OH, Kligman AM. Propionibacterium levels in patients with and without acne vulgaris. J Invest Dermatol 1975;65:382-4.
[Google Scholar]
33.
Simpson NB, Cunliffe WJ. Disorders of the sebaceous gland. In: Burns T, Breathnach S, Cox N, Griffiths C, editors. Textbook of dermatology. 7 th ed. Oxford: Blackwell Science; 2004. p. 43.22.
[Google Scholar]
34.
Webster GF, Tsai CC, Leyden JJ. Neutrophil lysosomal release in response to Propionibacterium acnes . J Invest Dermatol 1979;72:209.
[Google Scholar]
35.
Webster GF, Kligman AM. A method for the assay of inflammatory mediators in follicular casts. J Invest Deramtol 1979;73:266-8.
[Google Scholar]
36.
Kapetanovic R, Cavaillon JM. Early events in innate immunity in the recognition of microbial pathogens. Expert Opin Biol Ther 2007;7:907-18.
[Google Scholar]
37.
Kim J, Ochoa MT, Kruzik SR, Takeuchi O, Uematsu S, Legaspi AJ, et al . Activation of toll-like recptor 2 in acne triggers inflammatory cytokine responses. J Immunol 2002;169:1535-541.
[Google Scholar]
38.
Jugeau S, Tenaud I, Knol AC, Jarousse V, Quereux G, Khammari A, et al . Induction of toll-like receptors by Propionibacterium acnes . Br J Dermatol 2005;153:1105-13.
[Google Scholar]
39.
Boprelli C, Merk K, Jacob K, Schaller M, Vogeser M, Weindl G, et al . In vivo porphyrin production by P. acnes in untreated acne patients and its modulation by acne treatment. Acta Dermatol Venereol 2006;86:316-9.
[Google Scholar]
40.
Bruggemann H, Henne A, Hoster F, Liesegang H, Wiezer A, Strittmatter A, et al . The complete genome sequence of Propionibacterium acnes : A commensal of human skin. Science 2004;305:671-3.
[Google Scholar]
41.
Jeremy AH, Holland DB, Roberts SG, Thomson KF, Cunliffe WJ. Inflammatory events are involved in acne lesion initiation. J Invest Dermatol 2003;121:20-7.
[Google Scholar]
42.
Zouboulis CC, Bφhm M. Neuroendocrine regulation of sebocytes: A pathogenetic link between stress and acne. Exp Dermatol 2004;13:31-5.
[Google Scholar]
43.
Holland DB, Jeremy AH, Roberts SG, Seukeran DC, Layton AM, Cunliffe WJ. Inflammation in acne scarring: A comparison of the responses in lesions from patients prone and not prone to scar. Br J Dermatol 2004;150:72-81.
[Google Scholar]

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