Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current Issue
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
Images in Dermatology
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Media and news
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Images
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Reviewers 2022
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Snippets
Special Article
Specialty Interface
Studies
Study Letter
Study Letters
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Systematic Review and Meta-Analysis
Systematic Reviews and Meta-analyses
Systematic Reviews and Meta-analysis
Tables
Technology
Therapeutic Guideline-IADVL
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
Therapy Letters
View Point
Viewpoint
What’s new in Dermatology
Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current Issue
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
Images in Dermatology
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Media and news
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Images
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Reviewers 2022
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Snippets
Special Article
Specialty Interface
Studies
Study Letter
Study Letters
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Systematic Review and Meta-Analysis
Systematic Reviews and Meta-analyses
Systematic Reviews and Meta-analysis
Tables
Technology
Therapeutic Guideline-IADVL
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
Therapy Letters
View Point
Viewpoint
What’s new in Dermatology
View/Download PDF

Translate this page into:

Letter to the Editor
2014:80:4;361-362
doi: 10.4103/0378-6323.136933
PMID: 25035373

Persistent skin donor site erythema: A simple physiological phenomenon

Sidharth Sonthalia1 , Rahul Arora2 , Rashmi Sarkar3
1 Skinnocence: The Skin Clinic, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India
2 Department of Dermatology and Sexually Transmitted Diseases, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India
3 Department of Dermatology and Sexually Transmitted Diseases, Maulana Azad Medical College and Lok Nayak Hospital, Delhi, India

Correspondence Address:
Sidharth Sonthalia
Skinnocence: The Skin Clinic, C - 2246,Sushant Lok - 1, Block - C,Gurgaon - 122 009, Haryana
India
How to cite this article:
Sonthalia S, Arora R, Sarkar R. Persistent skin donor site erythema: A simple physiological phenomenon. Indian J Dermatol Venereol Leprol 2014;80:361-362
Copyright: (C)2014 Indian Journal of Dermatology, Venereology, and Leprology

Sir,

Even though we often look for unusual explanations for unusual clinical phenomena, sometimes a simple explanation proves to be correct. We describe the case of a young man who presented with persistent donor site erythema following split thickness grafting, where investigations and therapeutic interventions failed to help. This should have been expected as it is a physiological phenomenon rather than a malady per se.

A 26-year-old man was referred to us by a surgeon after performing split thickness skin grafting 12 months back for congenital bilateral syndactyly of toes. The donor skin was harvested from the left leg, which healed normally in 3 weeks. However, asymptomatic redness with crusting persisted over the donor site and after 3 months he was referred to us. On examination of the donor site, there was a large (4 × 10 cm) patch with fiery erythema on a background of depigmentation over the shin and lateral aspect of left leg, with mild crusting but no discharge or tenderness [Figure - 1]. The recipient site was normal. The distressed patient was considering possibilities of infection and even cancer. He reported applying mupirocin ointment over that area regularly for a month after surgery and mometasone ointment for 2 months without improvement. There was no history of any other topical or oral medications and no features suggestive of nutritional deficiencies or any systemic disorder. Suspecting mupirocin or mometasone and/or vehicle (propylene glycol) induced sensitization, we conducted a patch test with Indian Standard Series (approved by the Contact and Occupational Dermatoses Forum of India (CODFI)) with additional patches for patient′s own mupirocin and mometasone ointment samples. However, the results were negative for all antigens including the suspected sensitizers. The patient refused a skin biopsy. A course of fluticasone cream for a month, followed by tacrolimus 0.1% ointment for another month was given without any improvement. A literature search indicated that this phenomenon was expected following grafting which prompted us to stop all topical medications, counsel the patient and advise him for monthly follow-up. After 3 and 6 months, there was progressive reduction in erythema [Figure - 2] and the patient was satisfied.

Figure 1: Fiery donor site erythema over the left leg with focal crusting, 3 months post-operatively following split skin thickness grafting
Figure 2: Significant reduction in donor site erythema at 6 months of observation period after a negative patch test and following cessation of all topical applications

Healing of the split skin graft donor site occurs in three phases: inflammation, tissue formation and remodeling with the latter involving regression of blood vessels. [1] Considered to be a non-inflammatory process, an increase in the microvasculature during wound healing has been hypothesized as the possible cause of scar erythema. [2] Though the exact time-point at which scar-erythema normalizes is unknown, findings of a recent study that objectively evaluated post-operative persistent donor site erythema have shown that the donor site may show up to 36% elevated erythema persisting for at least 12 months versus the normal skin (P < 0.0005). [1] Thus, persistent donor site erythema is indeed a purely physiological phenomenon which needs no treatment per se. The associated depigmentation has also been described as one of the donor site complications which in this case may have worsened with topical steroids. [3] In a recent case-controlled study of 10 patients, Itoh et al. showed that topical hyperthermia applied to the donor site using chemical pocket warmers (daily for 8 hours for 8 weeks) resulted in decreased erythema and blood flow in all subjects without any adverse effects. [4] However, we preferred patient counseling and observation in our case.

References
1.
Danielsen PL, Jorgensen LN, Jørgensen B, Karlsmark T, Agren MS. Erythema persists longer than one year in split-thickness skin graft donor sites. Acta Derm Venereol 2013;93:281-5.
[Google Scholar]
2.
Bond JS, Duncan JA, Mason T, Sattar A, Boanas A, O'Kane S, et al. Scar redness in humans: How long does it persist after incisional and excisional wounding? Plast Reconstr Surg 2008;121:487-96.
et al. Scar redness in humans: How long does it persist after incisional and excisional wounding? Plast Reconstr Surg 2008;121:487-96.'>[Google Scholar]
3.
Young T, Fowler A. Nursing management of skin grafts and donor sites. Br J Nurs 1998;7:324-6, 328, 330 passim.
[Google Scholar]
4.
Itoh Y, Ishikawa M, Ishibashi A. Decrease in donor site erythema by application of hyperthermia. Ann Plast Surg 1998;41:162-5.
[Google Scholar]

Fulltext Views
3,188

PDF downloads
1,614
Show Sections