Generic selectors
Exact matches only
Search in title
Search in content
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL International Awards 2018
Images in Clinical Practice
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Special Article
Specialty Interface
Studies
Study Letter
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Tables
Technology
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
View Point
Viewpoint
What’s new in Dermatology
Case Report
2002:68:2;103-103
PMID: 17656895

Pigmented xerodermoid

M Ramesh Bhat, Sanjay Maman Cherian, JN Shetty
 Department of Skin and STD, Fr. Muller's Medical College, Kankanady, Mangalore-575 002, India

Correspondence Address:
M Ramesh Bhat
Department of Skin and STD, Fr. Muller's Medical College, Kankanady, Mangalore-575 002
India
How to cite this article:
Bhat M R, Cherian S, Shetty J N. Pigmented xerodermoid. Indian J Dermatol Venereol Leprol 2002;68:103
Copyright: (C)2002 Indian Journal of Dermatology, Venereology, and Leprology

Abstract

An 18- year-old female who presented with features suggestive of pigmented xerodermoid is reported.
Keywords: Xeroderma pigmentosum, Pigmented xerodermoid

Introduction

Xeroderma pigmentosum (XP) is a rare autosomal recessive disease characterized by photosensitivity, pigmentary changes, premature skin ageing, neoplasia and abnormal DNA repair. Some patients with xeroderma pigmentosum have in addition, neurological complications.[1] Many cases of pigmented xerodermoid have been reported under the diagnosis of xeroderma pigmentosum of late onset and this does indeed describe the clinical features. The onset may be delayed till the third or fourth decade. In pigmented xerodermoid,repair replication is normal, but there is total depression of DNA synthesis after exposure to UV radiation.[2]

Case Report

An 18-year-old female presented with asymptomatic, blackish discolouration of the face, neck and forearms of six years duration. Initially the lesions were on the forehead and nose which spread on to the cheeks, neck and forearms in two years time. There was history of photosensitivity and photophobia and history of remission and exacerbations.

There was no history of consanguinity and none in family had similar disease. Clinical examination revealed hyperpigmented macules 24 mm in size, over the face, neck and extensor aspect of the forearms. There were areas of achromia interspersed with areas of hyperpigmentation. Ocular examination was normal. Skin biopsy taken from the lesion showed hyperkeratosis and thinned epidermis along with melanin incontinence. Patient was treated with sunscreen, glycolic acid 10% topically and antioxidants orally. [Figure - 1]

Discussion

Xeroderma pigmentosum has atleast eight subtypes that are recognized, designated complimentation groups A - G and X P variant. Pigmented xerodermoid is xeroderma pigmentosum of late onset, usually in the third or fourth decade. In these patients repair replication is normal, but there is almost total depression of DNA synthesis after exposure to UV radiation.[2] In this case the history and clinical features were suggestive of xeroderma pigmentosum of late onset i.e. pigmented xerodermoid.

References
1.
Powsey SA, Magners IA, Ramsay, et al. Clinical genetic and DNA repair studies on a consecutive series of patients with xeroderma pigmentosum. Q J Med 1979;48:179-210.
[Google Scholar]
2.
Harper JL. Genetics genodermatoses. In Rook/Wilkinson/Ebling Textbook of Dermatology, Edited by Champion RH, Burton JL, Burns DA and Breathnoch SM, 6th Edn, Blackwell Science Publishers. Oxford 1998:407-412.
[Google Scholar]
Show Sections