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Plasma cell cheilitis as angular cheilitis
Corresponding author: Dr. Lata Goyal, Periodontology Division, Department of Dentistry, All India Institute of Medical Sciences, Bathinda, India. latagoyal83@gmail.com
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Received: ,
Accepted: ,
How to cite this article: Bansal S, Goyal L, Rana MK. Plasma cell cheilitis as angular cheilitis. Indian J Dermatol Venereol Leprol. doi: 10.25259/IJDVL_1634_2024
A 50-year-old woman presented with erythematous to whitish ulcerated plaques of size 2 × 1 cm present at both angles of the mouth involving the adjacent upper and lower lips [Figure 1]. KOH microscopy from the skin scrapings were negative. Due to lack of improvement with topical steroids and antifungals, an incisional biopsy was performed which showed hyperkeratosis and irregular acanthosis in the epidermis and a dense plasmacytic infiltrate in the upper dermis and dermo-epidermal junction, suggestive of plasma cell cheilitis [Figure 2a] confirmed on immunohistochemical [Figure 2b-d]. Patient was advised to discontinue any potential allergens that could trigger a hypersensitivity reaction, including cosmetic products, chewing gum, and non-essential food additives. She showed improvement after 2 weeks. Our case highlights the consideration of plasma cell cheilitis in nonresponsive angular cheilitis presentation.
- Erythematous plaque present at both angles of the mouth.
- Hyperkeratosis and irregular acanthosis, dense diffuse plasma cell infiltrate at the dermoepidermal junction and upper dermis (asterisk) (Haematoxylin & eosin, 200x)
- The plasma cells express positivity for b) k-expression, c) λ expression and d) CD138 expression (IHC, 400x)
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