Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current Issue
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
Images in Dermatology
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Media and news
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Images
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Reviewers 2022
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Snippets
Special Article
Specialty Interface
Studies
Study Letter
Study Letters
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Systematic Review and Meta-Analysis
Systematic Reviews and Meta-analyses
Systematic Reviews and Meta-analysis
Tables
Technology
Therapeutic Guideline-IADVL
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
Therapy Letters
View Point
Viewpoint
What’s new in Dermatology
Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current Issue
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
Images in Dermatology
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Media and news
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Images
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Reviewers 2022
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Snippets
Special Article
Specialty Interface
Studies
Study Letter
Study Letters
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Systematic Review and Meta-Analysis
Systematic Reviews and Meta-analyses
Systematic Reviews and Meta-analysis
Tables
Technology
Therapeutic Guideline-IADVL
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
Therapy Letters
View Point
Viewpoint
What’s new in Dermatology
View/Download PDF

Translate this page into:

Net letter
2012:78:5;665-665
doi: 10.4103/0378-6323.100551

Radiotherapy-induced koebnerization in lichen planus

Avinash A Sajgane, Atul M Dongre
 Department of Dermatology, Seth G. S. Medical College and K.E.M. Hospital, Parel, Mumbai, Maharashtra, India

Correspondence Address:
Avinash A Sajgane
87/ 204 A Wing Madhukunj CHS, Nehru Nagar, Kurla East, Mumbai 24, Maharashtra
India
How to cite this article:
Sajgane AA, Dongre AM. Radiotherapy-induced koebnerization in lichen planus. Indian J Dermatol Venereol Leprol 2012;78:665
Copyright: (C)2012 Indian Journal of Dermatology, Venereology, and Leprology

Sir,

Lichen planus (LP) is an inflammatory dermatosis of autoimmune origin, which affects the skin and mucosae. The Koebner phenomenon is the development of isomorphic pathologic lesions in the traumatized uninvolved skin of patients who have cutaneous diseases. These new lesions are clinically and histopathologically identical to those in the diseased skin. [1] This phenomenon has been described in various dermatoses including LP. However, the appearance of LP confined to an irradiated site is extremely rare.

A 40-year-old male presented to our outpatient department with complaint of itchy hyperpigmented lesions on the left foot and right knee. Lesions on the left foot appeared 2 years ago while those on the right knee were of 2-month duration. Two years back he took treatment for skin lesions on the left foot in the form of topical and oral medication with minimal improvement. On detailed history, we came to know that he was a case of non- Hodgkin lymphoma (diffuse large B-cell lymphoma) of right knee joint and had received chemotherapy (CHOP) 6 months back. He had also received external beam radiotherapy with Cobalt 60 in a dose of 45 Gy for 1 month on the right knee joint for lymphoma. After a month of radiotherapy, new itchy hyperpigmented lesions appeared on the right knee.

His physical examination was normal except slight swelling of the right knee. Cutaneous examination revealed multiple violaceous, hyperpigmented, shiny papules and plaques on the right knee [Figure - 1]. Violaceous and hyperpigmented papules were also seen on the left foot [Figure - 2]. Lesions on the right knee coincided exactly with the irradiated area. His mucosal examination was normal. Biopsy of papules from the right knee and the left foot showed wedge-shaped hypergranulosis, lichenoid infiltrate consisting of lymphocytes hugging the basal layer and saw toothing of the rete ridges [Figure - 3]. Thus, a diagnosis LP with radiotherapy-induced koebnerization was confirmed.

Figure 1: Multiple shiny, violaceous, hyperpigmented papules and plaques on the right knee
Figure 2: Violaceous and hyperpigmented papules on the left foot
Figure 3: Wedge-shaped hypergranulosis, lichenoid infiltrate consisting of lymphocytes hugging the basal layer and saw toothing of the rete ridges (H and E, ×200)

The Koebner phenomenon is particularly characteristic of psoriasis and LP but occurs in several other dermatoses like lichen nitidus, vitiligo, and lichen sclerosus. The Koebner phenomenon may follow various kinds of trauma which may be mechanical, thermal, chemical, or photo. Various therapies such as Grenz ray therapy, roentgen therapy, and ultraviolet light therapy are known to act as provocative factors. UV light is known to induce lesions of actinic LP. On the other hand, psoralen plus ultraviolet A has been found useful for the treatment of LP. Apart from LP, variety of skin conditions like lichen sclerosus et atrophicus, bullous pemphigoid, pemphigus foliaceus, and pemphigus vulgaris have been reported to be occur following radiotherapy. [2]

New lesions as such can appear in untreated case of LP but in our case as the new lesions occurred exactly at the site of radiotherapy with no new lesion elsewhere on the body, we propose these lesions on the knee to be a result of koebnerization induced by radiotherapy.

Little is known about the mechanism by which LP develops after radiotherapy. Radiotherapy is known to have immunomodulatory properties. Some of the mechanisms which were put forward includes increased expression of proinflammatory molecules such as major histocompatibility complex (MHC), adhesion molecules (ICAM-1 and E-selectin), increased expression of cytokines (IL-1, IL-6, IL-8,TNF-alpha, TGF beta), release of autoantigens or antigenic peptides by damage caused by radiotherapy, and degradation of the basement membrane by increased matrix metalloproteases (MMPs). [3],[4]

LP induced by radiotherapy may be confined to the site of exposure or it may present as generalized eruption. The appearance of LP confined to an irradiated site is very rare and only few cases have been published. [2],[3],[5],[6]

In some of the cases reported in the literature, patients had no prior history of LP and the lesions appeared for the first time after radiotherapy. Only one case reported by Pretel et al. had a history of the presence of similar lesions as in our case. [5] Shurman has suggested the term "isoradiotopic" response to describe the phenomenon of secondary dermatoses arising in radiation fields. [2]

Thus, we present one more rare case of LP where external radiotherapy-induced koebenerization occurred exactly at the site of irradiation and propose that external radiotherapy should be considered as one more factor for the cause of koebnerization in various dermatoses.

References
1.
Thappa DM. The isomorphic phenomenon of Koebner. Indian J Dermatol Venereol Leprol 2004;70:187-9.
[Google Scholar]
2.
Shurman D, Reich HL, James WD. Lichen planus confined to a radiation field: The isoradiotopic response. J Am Acad Dermatol 2004;50:482-3.
[Google Scholar]
3.
Sciallis GF, Loprinzi CL, Davis MD. Lichen planus induced by radiotherapy. Br J Dermatol 2005;152:399-401.
[Google Scholar]
4.
Morar N, Francis ND. Generalized lichen planus induced by radiotherapy: Shared molecular mechanisms? Clin Exp Dermatol 2009;34:434-5.
[Google Scholar]
5.
Pretel M, Espana A. Lichen planus induced by radiotherapy. Clin Exp Dermatol 2007;32:582-3.
[Google Scholar]
6.
Kim JH, Krivda SJ. Lichen planus confined to a radiation therapy site. J Am Acad Dermatol 2002;46:604-5.
[Google Scholar]

Fulltext Views
2,520

PDF downloads
2,923
Show Sections