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Letter To Editor
Response by the authors
S Prabhu, SD Shenoi
Deartment of Skin & STD, Kasturba Medical College & Hospital, Manipal, India
Correspondence Address:
S Prabhu
Deartment of Skin & STD, Kasturba Medical College & Hospital, Manipal
India
Correspondence Address:
S Prabhu
Deartment of Skin & STD, Kasturba Medical College & Hospital, Manipal
India
| How to cite this article: Prabhu S, Shenoi S D. Response by the authors. Indian J Dermatol Venereol Leprol 2003;69:363-364 |
Copyright: (C)2003 Indian Journal of Dermatology, Venereology, and Leprology
Sir,
We wish to thank Dr M. J. Cyriac for spotting the error and enlightening the readers about the interaction of cyclosporin with grapefruit and not grape juice. We are happy that our article has been thoroughly scrutinized.
A point to be noted is that although sweet orange juice is safe, a variety of sour oranges used in marmalades called Seville oranges contain 6,7 dihydroxybergamottin, the furanocoumarin compound found in grapefruit. However a recent study[1] has not found interaction of Seville orange juice with cyclosporine.
References
| 1. |
Edwards DJ, Fitzsimmons ME, Schuetz EG et al. 6, 7 dihydroxybergamottin in grapefruit juice and Seville orange juice: effects on cyclosporine disposition, enterocyte CYP3A4 and P-glycoprotein. Clin Pharmacol Ther 1999;65:237-44.
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