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Observation Letter
ARTICLE IN PRESS
doi:
10.25259/IJDVL_27_2021

Reticulated atrophic skin lesions in an adult patient with dermatomyositis and antinuclear matrix protein-2 autoantibodies

Department of Dermatology and Venereology, Medical University - Sofia, Sofia, Bulgaria
Clinic of Clinical Immunology and Stem Cell Bank, University Hospital “Alexandrovska”, Sofia, Bulgaria
Corresponding author: Prof. Lyubomir Dourmishev, Department of Dermatology and Venereology, Medical University - Sofia, Sofia, Bulgaria. l_dourmishev@yahoo.com
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This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, transform, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

How to cite this article: Pozharashka J, Botev I, Lesichkova S, Miteva L, Dourmishev L. Reticulated atrophic skin lesions in an adult patient with dermatomyositis and antinuclear matrix protein-2 autoantibodies. Indian J Dermatol Venereol Leprol doi: 10.25259/IJDVL_27_2021

Sir,

Dermatomyositis is an autoimmune connective tissue disorder classically manifesting with cutaneous inflammation and myopathy. Recently, multiple novel myositis-specific autoantibodies have been described which have been linked to different clinical phenotypes of the disease. Antinuclear matrix protein-2 autoantibodies, in particular, are associated with mild skin involvement, calcinosis, peripheral oedema, myalgia and dysphagia, as well as paraneoplastic dermatomyositis in adults.1

A 32-year-old man presented to our dermatology department with erythematous rash on the face [Figure 1a]; erythematous papules and crusted erosions on the chest [Figure 1b] and reticulated atrophic plaques on the right shoulder [Figure 1c] and both arms. The reticulated plaques were atrophic and whitish, situated on an erythematous base and were covered with few yellowish crusts. Dermoscopy demonstrated telangiectasias, skin atrophy and crusts [Figure 2]. The patient lacked the typical cutaneous features of dermatomyositis (heliotrope erythema, Gottron’s sign/papules). He had noticed skin lesions for two months and also reported severe muscle weakness, myalgia and dysphagia to solids.

Figure 1a:: Violaceous erythema on the face
Figure 1b:: Crusted erosions on the chest
Figure 1c:: Reticulated atrophic plaque on the right shoulder
Figure 2:: Dermoscopy of crusted and atrophic skin lesion (×10, DermLite DL1, OnePlus 3T Camera, polarisation mode)

Complete blood count was normal but serum biochemistry revealed elevated alanine aminotransferase (95 IU/L), aspartate aminotransferase (172 IU/L), gamma-glutamyl transfease (75 IU/L) and creatine kinase (3769 IU/L). Electromyography revealed myogenic injury of the proximal muscles of the upper and lower extremities compatible with inflammatory myopathy. Muscle biopsy was not performed.

Skin biopsy from the face demonstrated atrophic epidermis, follicular hyperkeratosis, sparse perivascular and periadnexal inflammatory infiltrate with perifollicular leukocytoclasia. Histology from chest erosion showed a lack of epidermis, fibrin crust with reactive hyperplasia in the surrounding epidermis and mild fibrosis in the upper dermis. Skin biopsy from the reticulated atrophic skin lesion on the right shoulder showed atrophic epidermis, moderate fibrosis in the upper dermis with widening of some of the collagen bundles and erythrocyte extravasation in papillary dermis [Figure 3]. A complete immunologic workup was done, including antinuclear antibodies, myositis specific [antiMi-2 antibody (Mi-2α), anti-Mi-2β antibody (Mi-2β), transcriptional intermediary factor 1γ (TIF1-γ), melanoma differentiation-associated protein 5 (MDA5), nuclear matrix protein 2 (NXP2), signal recognition particle (SRP), SUMO-activating enzyme subunit 1 (SAE1), EJ, OJ, PL-7, PL-12 and Jo-1] and associated autoantibodies (Ku, PM/Scl-75, PM/Scl-100 and anti-Ro52), as well as antiphospholipid, anti-La, anti-ribonucleoprotein (RNP), anti-Sm, anti-double-stranded-DNA autoantibodies and C3 and C4 factors of complement. It revealed high titres of antinuclear antibodies – 1:320 (positive >1:160; indirect immunofluorescence on Hep-2 cells) and antinuclear matrix protein-2 autoantibodies – strong positive, +++ (immunoblot assay). All the other autoantibodies, C3 and C4 were within reference ranges. A diagnosis of dermatomyositis was confirmed.

Figure 3:: Histology from the right shoulder lesion shows atrophic epidermis, moderate fibrosis in the upper dermis with widening of some of the collagen bundles and erythrocyte extravasation in papillary dermis (H&E, ×100)

Paraneoplastic screening, comprising abdominal sonography, chest X-ray, tumour markers (PSA – prostate-specific antigen, CA19-9 – carbohydrate antigen 19-9 and AFP – α-fetoprotein) and serum immunofixation, excluded the presence of malignancy.

Echocardiography revealed no abnormality. Phototesting demonstrated an increased photosensitivity toward short wave ultraviolet B. Serology for Lyme disease was negative.

Treatment with methylprednisolone 40 mg/daily and methotrexate 15 mg weekly resulted in improvement of muscle symptoms. A moderate potency corticosteroid cream was applied on skin lesions other than reticulated atrophic plaques which led to subsidence of skin rash except for the facial livid erythema and the reticulated atrophic lesions.

The history of dysphagia and myalgia was typical for antinuclear matrix protein-2 phenotype.1 However, some unusual skin lesions were also present. Erosions are generally considered a marker for paraneoplastic dermatomyositis but no evidence of malignancy was found in our patient. We plan to keep the patient under follow up as malignancy may be diagnosed even 3-5 years after diagnosis of dermatomyositis. The localised reticulated atrophic plaques were the most striking finding and several conditions were discussed in differential diagnosis as follows. Poikiloderma in dermatomyositis affects the sun-exposed skin but it is usually a late finding.2 Poikiloderma atrophicans vasculare is characterised by a limited number of patches with a reticulate pattern and is considered a variant of mycosis fungoides.2

Histology of skin lesions in our patient ruled out the possibility of mycosis fungoides. Cutaneous leucocytoclastic vasculitis, when reported in dermatomyositis, affects paraneoplastic cases and the lesions lack a reticulated pattern.3 Livedoid vasculopathy resolves with characteristic atrophie blanche like scarring. In association with dermatomyositis, it usually affects elderly individuals with malignancies.4 Morphea and atrophoderma of Pasini and Pierini do not exhibit reticulated pattern and the clinical presentation differs. In addition, serology for Lyme disease was negative in our patient. A few cases of dermatomyositis with Degos-like skin changes have been described and only one with positive antinuclear matrix protein-2 autoantibodies.5

We were unable to find any previous reports that described similar reticulated atrophic skin lesions in dermatomyositis. Further follow-up would be needed to elaborate the correct diagnosis for the reticulated atrophic plaques in our patient. The question whether these specific lesions might be related to the antinuclear matrix protein-2 phenotype remains open.

Acknowledgements

The authors are grateful to Prof. E. Naumova and Prof. A. Mihaylova for their support in the immunology investigation of the patient.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent.

Financial support and sponsorship

This study was fulfilled with the financial support of Medical University of Sofia under a PhD grant.

Conflicts of interest

There are no conflicts of interest.

References

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  5. , , . Degos-like cutaneous findings in an adult woman with NXP-2-associated dermatomyositis. JAMA Dermatol. 2020;156:218-20.
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