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Scars in dermatology: Clinical significance
Arun C Inamadar
Department of Dermatology, Venereology and Leprosy, BLDEA's SBMP Medical College, Hospital and Research Centre, Bijapur - 586103, Karnataka
|How to cite this article:
Anitha B, Ragunatha S, Inamadar AC. Scars in dermatology: Clinical significance. Indian J Dermatol Venereol Leprol 2008;74:420-423
A scar is a scar is a scar and only a scar if you don′t ask why"
- Shelly and Shelly
A scar is a fibrous tissue replacement that develops as a consequence of healing at the site of a prior ulcer or wound. Cutaneous scarring is a macroscopic disturbance of the normal structure and function of the skin architecture manifesting itself as an elevated or depressed area, with an alteration of skin texture, color, vascularity, nerve supply and biomechanical properties. 
Histologically, dermal scars are characterized by thickened epidermis with a flattened dermo-epidermal junction and an abnormal organization of the dermal matrix into parallel bundles of scar tissue collagen, as opposed to the normal basket weave pattern of dermal collagen. Scar collagen fibers have high proportions of type III collagen and fibronectin compared to the surrounding normal skin and are usually smaller and more densely packed. Elastic fibers are fragmented and abnormally organized in scars as compared to the normal dermis. Epidermal appendages such as hair follicles and sebaceous glands are usually absent in a scar. 
The pathogenesis of raised skin scars is unclear. Fibroblasts from hypertropic scars and keloids demonstrate excessive proliferative and low apoptosis properties. Fibrogenic isoforms of transforming growth factor β (TGF β 1, 2, 3 ) appear to play a central role in the pathogenesis process. TGF β 1 stimulates fibroblasts leading to proliferation and synthesis of procollagen RNA and hence, collagen formation. By upregulating the production of tissue inhibitor metalloproteinase and plasminogen activator inhibitor, TGF β 1 protects the collagen from degradation. 
Classification of Scars 
- Fine line scars: Surgical scars
- Wide (stretched) scars: These develop when fine line surgical scars gradually become stretched and widened. They are typically flat, pale, soft, symptomless scars. Abdominal striae of pregnancy can be considered as variants of these.
- Atrophic scars: These are flat or depressed below the surrounding skin. They are generally small and often round with an indented or inverted centre. They commonly arise after acne or chickenpox.
- Scar contractures: Scars across joints or skin creases at right angles are prone to develop shortening or contracture. They commonly occur after burn injury across joints or skin concavities.
Raised skin scars:
a. Hypertropic scars: These are raised scars that remain within the boundaries of the original lesion, generally regressing spontaneously after the initial injury. They are often red, inflamed, itchy, and even painful.
b. Keloidal scars: These are raised skin scars that spread beyond the margins of the original wound and invade the surrounding normal skin. A keloid continues to grow over time, does not regress spontaneously and almost invariably recurs after simple excision.
- Intermediate scar: Scars that are difficult to categorize have been termed intermediate scars.
Dermatological Conditions Which Result in Scars
Scars do not just occur as a consequence of the healing process, but also have other clinical significance. They may serve as a clue for diagnosis by their typical morphology or may give rise to various dermatoses while some dermatoses may mimic scars. These aspects of scars are discussed below.
Dermatological Conditions Occurring in Scars
Certain dermatological conditions arise from a scar and have a tendency to recur within the scar tissue. These disorders may occur in scars as a result of Koebner′s phenomenon, inoculation of infectious agents, metastases or long-standing changes in the scars [Table - 3]. In pseudoxanthoma elasticum, the disease process can be demonstrated in scars before the appearance of skin lesions. In such cases, a biopsy of the scar has been used for diagnosis of the disease. 
Dermatoses Mimicking Scars
Some dermatoses may clinically mimic a scar requiring careful examination and histopathological studies to confirm the diagnosis. The absence of history of prior injury should raise suspicion of these disorders [Table - 4].
Spontaneous Scarring and Pseudoscars
Scars can occur without any history of previous trauma. These tend to occur in predisposed individuals. However, there may be prior trivial trauma, hemorrhage  or dermatitis unnoticed by the patient. 
Atrophia maculosa varioliformis cutis: In this condition, spontaneous atrophic linear, rectangular or varioliform scars with sharp margins develop over the cheeks of children and young adults. 
Stellate and discoid pseudoscars: Stellate pseudoscars are white, irregular or star-shaped atrophic scars occurring over the sun-exposed areas of the forearms. It is commonly seen in elderly individuals aged 70-90 years. Brown pseudoscars are known to occur over the shins of patients with diabetic dermopathy. 
In most of the cases, except for cosmetic unacceptability, a scar is not a cause for much concern. However, a simple scar can be a site for the development of various dermatoses or it can undergo neoplastic changes over time. Hence, any long-standing scar with or without morphological changes, should be examined carefully and should be biopsied if necessary.
Breathnach SM, McGrath JA. Wound healing. In: Burns T, Breathnach S, Cox N, Griffiths C, editors, Rook's textbook of dermatology. 7th ed. Oxford: Blackwell Science Ltd; 2004. p. 11.1-11.25.[Google Scholar]
Robson MC. Proliferative scarring. Surg Clin N Am 2003;83:557-69.[Google Scholar]
Bayat A, McGrouther DA, Ferguson MW. Skin scarring. Br Med J 2003;326:88-92.[Google Scholar]
Ghatan HEY. Morphologic eruptions. Dermatological differential diagnosis and pearls, 1 st ed. New York: The Parthenon Publishing Group; 1994. p. 37-45.[Google Scholar]
Shelley BW, Shelley ED. Scar. In: Advanced dermatologic diagnosis, 1 st ed. Philadelphia: W.B. Saunders Company; 1992. p. 1153-6.[Google Scholar]
Gupta AK, Rasmussen JE, Headington JT. Extensive congenital erosions and vesicles healing with reticular scarring. J Am Acad Dermatol 1987;17:369-76.[Google Scholar]
Lebwohl M, Phelps RG, Yannuzzi L, Chang S, Schwartz I, Fuchs W. Diagnosis of pseudoxanthoma elasticum by scar biopsy in patients without characteristic skin lesions. N Engl J Med 1987;317:347-50.[Google Scholar]
Ghatan HE, editor. General dermatological and dermatopathological pearls. In: Dermatological differential diagnosis and pearls. 1 st ed. New York: The Parthenon Publishing Group; 1994. p. 217- 51.[Google Scholar]
Rao AG, Jhamnani KK, Konda C. Nodular melanoma in a skin graft site scar. Indian J Dermatol Venereol Leprol 2008;74:159-61.[Google Scholar]
Colomb D. Stellate spontaneous pseudoscars, Senile and presenile forms: Especially those forms caused by prolonged corticoid therapy. Arch Dermatol 1972;105:551-4.[Google Scholar]
Kolenik SA, Perez MI, Davidson DM, Morganroth GS, Kohn SR, Bolognia JL. Atrophia maculosa varioliformis cutis. J Am Acad Dermatol 1994;30:837-40.[Google Scholar]