Short-term treatment of pityrosporum folliculitis with itraconazole
Dept. of Dermatology, Himalayan Institute of Medical Sciences, Jolly Grant. Dehradun, U.P. - 248 140
|How to cite this article:
Parsad D, Saini R, Negi K S. Short-term treatment of pityrosporum folliculitis with itraconazole. Indian J Dermatol Venereol Leprol 1999;65:122-123
We compared the efficacy and safety of short-term itraconazole with that of placebo in 26 patients of pityrosporum folliculitis. Twenty-six patients of mycologically proven pityrosporum folliculitis entered a double-blind placebo-controlled trial. Patients were randomly assigned to 7 days of treatment with either itraconazole, 200 mg once daily, or placebo. A global clinical assessment and micological examination (KOH und smear examination) were performed at baseline and at 4 weeks after treatment. In this study, itraconazole in a dose of 200mg for 7 days produced a distinct and statistically significant improvement over placebo (p<0.01). 84.6% of itraconazole treated patients were considered to be healed or markedly improved at the study’s end point compared with 8.3% of placebo treated group (p<0.0). Eighty-four percent of patients receiving active treatment showed negative mycological examination as compared to 8.3% of placebo-treated group (p<0.0l). Short-term treatment with itraconazole is effective and well tolerated in the management of pityrosporum folliculitis.