Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Art & Psychiatry
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Conference Oration
Conference Summary
Continuing Medical Education
Cosmetic Dermatology
Current Best Evidence
Current Issue
Current View
Derma Quest
Dermato Surgery
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
Editor Speaks
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
In Memorium
Inaugural Address
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Medicolegal Window
Miscellaneous Letter
Net Case
Net case report
Net Image
Net Letter
Net Quiz
Net Study
New Preparations
News & Views
Observation Letter
Observation Letters
Original Article
Original Contributions
Pattern of Skin Diseases
Pediatric Dermatology
Pediatric Rounds
Presedential Address
Presidential Address
Presidents Remarks
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Review Article
Review Articles
Revision Corner
Self Assessment Programme
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Special Article
Specialty Interface
Study Letter
Study Letters
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Systematic Review and Meta-Analysis
Systematic Reviews and Meta-analyses
Systematic Reviews and Meta-analysis
Therapeutic Guideline-IADVL
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapy Letter
Therapy Letters
View Point
What’s new in Dermatology
View/Download PDF

Translate this page into:

Therapy Letter
88 (
); 667-670

Successful treatment of facial cutaneous leishmaniasis with photodynamic therapy

Department of Dermatology, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain
Department of Pathology, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain
Corresponding author: Dr. Paula Aguilera Peiró, Department of Dermatology, Hospital Clínic de Barcelona, Barcelona, Spain.
This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, transform, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

How to cite this article: Alamon-Reig F, Martí-Martí I, Riquelme-Mc Louglin C, Garcia A, Carrera C, Aguilera-Peiró P. Successful treatment of facial cutaneous leishmaniasis with photodynamic therapy. Indian J Dermatol Venereol Leprol 2022;88:667-70.


Leishmaniasis is a widespread protozoan zoonosis transmitted by sandflies that can cause a wide range of manifestations. Cutaneous leishmaniasis is the most common form, usually presenting as a papule on exposed skin that enlarges and finally ulcerates. Therapies for cutaneous leishmaniasis are limited and the systemic treatments available are hampered by toxicity and parasite resistance. As an alternative, photodynamic therapy has been reported to be a safe and effective treatment for cutaneous leishmaniasis.1,2

An otherwise healthy woman in her 60s, presented to the dermatology department with a solitary, asymptomatic, violaceous papule on her left cheek that enlarged slowly in the past four months [Figure 1a]. Travel history was significant for a trip to Peru, mainly the urban areas, one year prior to the current complaint. Dermoscopic examination showed a symmetric mildly pigmented lesion, with some comedo-like openings, white interfollicular structures and a few focused telangiectatic vessels [Figure 1b]. Reflectance confocal microscopy (Vivascope 3000, Mavig, Germany) revealed dilated follicular openings in the epidermis, marked adnexal structures and dense material in the superficial dermis with inflammatory cells and prominent horizontal vessels. With the suspected diagnosis of cutaneous leishmaniasis, a punch biopsy was performed. Histopathologic examination showed dilatation of the follicular infundibulum associated with a mixed inflammatory infiltrate in the dermis. Non-necrotizing granulomas and intracytoplasmic structures compatible with amastigotes were also observed, confirming the diagnosis of cutaneous leishmaniasis [Figures 1d-f]. After discussing treatment options with the patient, local therapy was chosen due to the potential side effects of systemic alternatives. The patient was treated with three courses of photodynamic therapy three weeks apart. Carbon dioxide (CO2) fractional laser was used as a drug delivery technique to improve the absorption of the photosensitizer (wavelength 10.600 nm, energy density 31.8 J/cm, coverage 8%, power 30W, beam size 500 μm). This method increases the therapeutic efficacy of photodynamic therapy, shortening the incubation time and contributing to a reduction in the number of photodynamic therapy sessions.3 Subsequently, topical 7.8% 5-aminolevulinic acid was applied and occluded for two hours. The lesion was then irradiated using a red light-emitting diode lamp (BF-RhodoLED®, 635 nm, 37 J/cm). After the third session, the lesion showed a complete clinical response with excellent cosmetic results [Figure 1c]. Photodynamic therapy was well tolerated and the patient only experienced mild erythema and a transient burning sensation as side effects. To confirm the treatment response, reflectance confocal microscopy was performed which demonstrated a regular honeycomb pattern with unremarkable dermal features two months later. The patient has not presented with a relapse of the lesion during six months of follow-up.

Figure 1:: (a) The initial clinical presentation showed a violaceous plaque on the left cheek. (b) Dermoscopy revealed superficial scales, orange comedo-like openings and white interfollicular structures over an erythematous background (DL100, 3Gen, California, ×10). (c) Clinical resolution after 3 sessions of photodynamic therapy. (d, e) The flattened epidermis marked dilation of the follicular infundibulum and a mixed dermal inflammatory infiltrate consisting primarily of lymphocytes, plasma cells and histiocytes (Hematoxylin and eosin, ×20) (Hematoxylin and eosin, ×40). (f) Scattered intracytoplasmic structures (arrows), consistent with leishmania amastigotes (Hematoxylin and eosin, ×100)

Although cutaneous leishmaniasis is usually a self-limited infection, treatment is advised to avoid ulceration, scarring or disease progression. Cutaneous leishmaniasis may constitute a therapeutic challenge since evidence for optimal treatment is ambiguous.2 Systemic drugs have potential adverse effects and the risks and benefits of the available therapies should be discussed with every patient. In recent years, photodynamic therapy has been introduced as a safe and effective alternative therapy for cutaneous leishmaniasis, with mild side effects and excellent cosmetic outcomes.1 It has been reported as a successful treatment for cutaneous leishmaniasis in at least 75 cases, most of which are due to L. donovani, L. major and L. tropica, and some with complex cutaneous leishmaniasis involving the face [Table 1]. Asilian et al.1 compared photodynamic therapy versus topical paromomycin and placebo, showing a complete response in 93.5% versus 41.3% and 13.3% of lesions respectively.1 Photodynamic therapyprotocols for treating cutaneous leishmaniasis have not yet been standardized. In most reported cases; topical aminolevulinic acid or methyl aminolevulinate were applied as photosensitizers, followed by incubation and red light irradiation, with three to eight weekly sessions. Enk et al.4 assessed the use of daylight-activated photodynamic therapy in 31 patients with cutaneous leishmaniasisand reported an overall cure rate of 89%. This modality requires almost no equipment and could be performed in rural areas and technologically underdeveloped countries.4 Although the response to treatment should be assessed by clinical criteria, testing for parasites is often performed.2 Despite the limitation of in-depth evaluation, reflectance confocal microscopy can help rule out common tumours of the face as it can show findings more suggestive of cutaneous leishmaniasis such as dilated linear and comma-shaped vessels, follicular plugging and the presence of multinucleated giant cells in the superficial dermis.5 Reflectance confocal microscopy, along with dermoscopy, could be a useful, non-invasive tool, not only to support the diagnosis of cutaneous leishmaniasis but also to monitor healing, avoiding unnecessary biopsies or additional photodynamic therapy sessions.

Table 1:: Studies and case reports describing cutaneous leishmaniasis treated with photodynamic therapy
Author & year No. (Lesions) Sex/Age Lesion location Leishmania species Therapy regimen Dose (Sessions) Outcome (weeks to achieve) Adverse effects Follow-up
Gardlo et al. 2003 1 (10) M/34 Left arm and leg L. donovani Five lesions:PDT with topical MAL and red light, 630 nm 75 J/cm2 (28) Complete response in all 5 lesions treated with PDT (16) Erythema, burning sensation during irradiation and residual hyperpigmentation 16 months with no clinical recurrence.
Enk et al. 2003 11 (32) NA NA L. major PDT with topical 5-ALA and red light, 570-670 nm 100 J/cm2 (1-3) Complete response in 96.9% of lesions (1-3) Transient burning sensation ND
Gardlo et al. 2004 1 (1) M/19 Left shoulder ND PDT with topical MAL and red light, 630 nm ND (5) Complete response (5) Burning, pain and suppuration in the irradiation zone. Residual hypopigmentation. 12 weeks with no clinical recurrence.
Asilian et al. 2006[1] 20 (ND) NA NA L. major PDT with topical 5-ALA and red light, 633 nm 100 J/cm2 (4) Complete response in 93.5% of lesions. Partial response in 6.5% (4) Mild pruritus, burning, erythema, oedema and pain ND
Ghaffarifar et al. 2006 5 (7) NA NA L. major PDT with topical 5-ALA and red light, 570-670 nm 100 J/cm2 (4) Complete response (4) Local inflammation and residual hyperpigmentation. 4 months with no clinical recurrence.
Sohl et al. 2007 1 (1) M/56 Left cheek L. tropica PDT with topical MAL and red light, 635 nm 100 J/cm2 (3) Complete response (6) ND ND
Pizinger et al. 2009 1 (9) M/39 Forearms, neck, and thigh ND Five lesions: PDT with topical 5-ALA and red light, 580-680 nm 75 J/cm2 (6) Complete response of the 5 lesions treated with PDT Minimal pigmentation and central scarring 12 months with no clinical recurrence.
Song et al. 2011 1 (3) M/ND Left flank, left ear and left cheek ND Low dose pentavalent antimony (5 mg/kg/d), PDT withmethylene blue and red light, 580-680 nm 20 J/cm2 (4) After the second PDT session, the lesion no longer comprised an open wound (2) ND ND
Evangelou et al. 2011 1 (1) M/69 Left cheek ND PDT with intralesional 20% 5-ALA, 630 nm 100 J/cm2 (3) Complete response (3) Local burning and erythema during irradiation 24 months with no clinical recurrence.
Enk et al. 2015[4] 27 (64) NA NA L. major and L. tropica SFP and daylight-activated PDT with topical MAL. Exposure to daylight during 2.5 hours. ND (<8) Complete response in 89% Mild pain was reported with a mean score of 0.6/10 ND
Fink et al. 2016 1 (3) F/18 Face, forearm and back of the hand L. tropica PDT with 5-ALA and red light, 630 nm 37 J/cm2 (5) Complete response (5) Local burning and erythema during irradiation 9 weeks with no clinical recurrence.
Sainz-Gaspar et al. 2018 1 (2) M/10 Left lower eyelid and left forearm ND Meglumine antimoniate + PDT with MAL and red light, 630 nm 37 J/cm2 (7) Complete resolution (7) Slight to moderate pain during irradiation and residual hypopigmented superficial scarring 3 months with no clinical recurrence
Slape et al. 2018 1 (1) M/29 Nose dorsum L. tropica PDT with MAL and red light, 630 nm ND (7) Complete resolution (7) ND Patient was lost to follow up
Broby Johansen et al. 2019 1 (1) M/15 Right lower leg L. major PDT with 5-ALA and red light 37 J/cm2 (24) Complete resolution (12) ND ND
Costin et al. 2020 1 (1) M/31 Forehead ND Meglumine antimoniate + PDT with MAL and red light, 630 nm 37 J/cm2 (8) Complete resolution (16) Local stinging and erythema during irradiation 12 months with no clinical recurrence
Goldin et al. 2020 1 (1) F/82 Left ear L. tropica PDT with 5-ALA and red light, 633 nm 75 J/cm2 (3) Recurrence 2 months after the second session. Complete resolution after the third session (18) ND 22 months with no clinical recurrence
Current case 1 (1) F/65 Left cheek ND Pre-treatment with fractional CO2 laser, PDT with 5-ALA and red light, 635 nm 37 J/cm2 (3) Complete resolution (9) Mild erythema and burning sensation. Residual hypopigmented superficial scarring 6 months with no clinical or RCM-assessed recurrence

No: number, M: Male, F: Female, PDT: photodynamic therapy, 5-ALA: 5-Aminolevulinic acid, MAL: Methyl aminolevulinate, ND: Not described, NA: Not applicable, SFP: Solar photoprotector, RCM: reflectance confocal microscopy

Photodynamic therapy is an effective and well-tolerated therapeutic option for the treatment of simple cutaneous leishmaniasis. The use of fractional CO2 laser as a drug-delivery method could shorten the number of photodynamic therapy sessions needed. Further studies are needed to establish the optimal photodynamic therapy protocol for treating cutaneous leishmaniasis and evaluate its use in cosmetically relevant regions. Reflectance confocal microscopy is a promising complementary tool in the diagnosis and follow-up of patients with cutaneous leishmaniasis.

Declaration of patients consent

The authors certify that they have obtained all appropriate patient consent.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.


  1. , . Comparison between the efficacy of photodynamic therapy and topical paromomycin in the treatment of Old World cutaneous leishmaniasis: A placebo-controlled, randomized clinical trial. Clin Exp Dermatol. 2006;31:634-7.
    [CrossRef] [PubMed] [Google Scholar]
  2. , , , , , , , et al. Diagnosis and Treatment of Leishmaniasis: Clinical practice guidelines by the infectious diseases society of America (IDSA) and the American society of tropical medicine and hygiene (ASTMH) Am J Trop Med Hyg. 2017;96:24-5.
    [CrossRef] [PubMed] [Google Scholar]
  3. , , , . Comparative analysis of the effects of CO2 fractional laser and sonophoresis on human skin penetration with 5-aminolevulinic acid. Lasers Med Sci. 2017;32:1895-1900.
    [CrossRef] [PubMed] [Google Scholar]
  4. , , , , , . Cutaneous leishmaniasis responds to daylight-activated photodynamic therapy: Proof of concept for a novel self-administered therapeutic modality. Br J Dermatol. 2015;172:1364-70.
    [CrossRef] [PubMed] [Google Scholar]
  5. , , , . In vivo confocal microscopy features of cutaneous leishmaniasis. Dermatology. 2014;228:121-4.
    [CrossRef] [PubMed] [Google Scholar]

Fulltext Views

PDF downloads
View/Download PDF
Download Citations
Show Sections