Therapeutic efifect of doxepin in chronic idiopathic urticaria

Abstract

Among 56 recalcitrant cases of chronic idiopathic urticaria 28 subjects (Group A) selected at random, were, treated with doxepin 10 mg thrice daily and the rest ( Group B ) with pheniramine maleate 22.5mgthrice daily.B 3 weeks of therapy group.A and group B respectively showed complete remission in 28.6% and 10.7% cases, partial remission in 64.3% and 39.3% cases and no improvement in 7.1% and 50% cases. The difference in clinical improvement between the two groups was statistii significant (p0.001). One week after stopping the treatment among totally syrnptom - free patients, 37.5% in group A and 100% in-group B developed recurrence. Drowsiness was more common in-group B (60.7%) than in group A (35.7%) whereas dryness of the mouth was more frequent in group A (64.3%) than in group B (46.4%).