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Letter To Editor
2008:74:3;282-283
doi: 10.4103/0378-6323.41394
PMID: 18583815

Tumoral calcinosis

Saurabh Jindal, Amar Surjushe, Prajct Sao, DG Saple
 Department of Dermatology, Venereology and Leprosy, Grant Medical College and Sir JJ Group of Hospitals, Mumbai, India

Correspondence Address:
Saurabh Jindal
6-D Malaygiri Apartments, Anushakti Nagar, Mumbai - 400 094
India
How to cite this article:
Jindal S, Surjushe A, Sao P, Saple D G. Tumoral calcinosis. Indian J Dermatol Venereol Leprol 2008;74:282-283
Copyright: (C)2008 Indian Journal of Dermatology, Venereology, and Leprology

Sir,

Calcinosis cutis, a group of disorders in which calcium is deposited in the skin is of four types: metastatic, dystrophic, idiopathic and intraepidermal calcified nodules. [1] Tumoral calcinosis is a special form of idiopathic calcinosis which affects adolescents and young adults [2] and is characterized by massive subcutaneous deposits of calcium phosphate near the joints such as hips, shoulders, elbows, wrists, feet and hands. The deposits consist of pleomorphic calcium phosphate (hydroxyapatite) crystals.

A 26 year-old married male presented with gradually increasing, painless, bony, hard masses over both the elbows and around the right hip joint prevalent since the last two years. There was no history of excessive milk or antacid intake, endocrinal abnormalities, or any history suggestive of any connective tissue disease. There was also no history of any similar condition in the family members.

On examination, there were firm-to-hard, nontender, irregular, tumorous masses over the lateral aspect of the right gluteal region measuring 15 x 15 cm, and over both elbows measuring about 10 x 8 cm with overlying skin showing atrophic scars. There was minimal restriction of movements at the joints [Figure - 1]. Systemic examination results were normal.

Hemogram, liver and renal function tests, and the erythrocyte sedimentation rate were normal. Serum phosphorus level was 6 mg% (normal range: 2-4.5 mg%). Serum calcium, uric acid, alkaline phosphatase, parathyroid hormone, calcitonin levels were normal. Antinuclear antibodies and the rheumatoid factor were absent. Radiographs showed large, lobulated, radio-opaque, soft tissue masses of calcific density with radiolucent septae in the juxta-articular position of both elbows and the right hip. Magnetic resolution imaging (MRI) of the right hip showed foci of calcification with infiltration into the gluteus medius and quadratus femoris [Figure - 2]. Histopathology from the elbow showed deeply basophilic amorphous granular material surrounded by dense fibrous tissue and infiltration [Figure - 3]. Debulking of the elbow regions was done and the patient is now on regular follow-up to detect any recurrence.

Tumoral calcinosis was first described in 1899. [3] The pathogenesis is obscure but the basic defect is thought to be in the proximal renal tubular cell with an elevated renal phosphate reabsorption threshold and increased production of 1, 25-dihydroxyvitamin D. [4] It is classified into three types depending upon the pathogenesis: primary normophosphatemic tumoral calcinosis (NPTC), primary hyperphosphatemic tumoral calcinosis (PHTC) and secondary tumoral calcinosis. [5] Our case is of subtype 2 having hyperphosphatemia with normal levels of serum calcium, parathyroid hormone and alkaline phosphatase. Tumoral calcinosis is often associated with diseases like chronic renal failure, primary hyperparathyroidism, hypervitaminosis D, milk-alkali syndrome, sarcoidosis and massive osteolysis. [5]

Typical clinical findings, radiology, fine needle aspiration cytology, and histopathology [3] showing calcification help in the diagnosis. Various treatment modalities like aluminium hydroxide or acetazolamide have been tried but none has been found to be effective. Complete surgical excision has been recommended but recurrences are common. [6]

References
1.
Maize J, Metcalf. Metabolic diseases of the skin. In : Elder D, editor. Lever's Histopathology of the skin. 8 th ed. Philadelphia: Lippincott- Raven; 1997. p. 379-82.
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Datta C, Bandyopadhyay D, Bhattacharyya S, Ghosh S. Tumoral calcinosis. Indian J Dermatol Venereol Leprol 2005;71:293.
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Lim S, Daruwalla JS, Wee A. Tumoral calcinosis: A case report. Ann Acad Med Singapore 1985;4:391.
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Lyles KW, Halsey DL, Friedman NE, Lobaugh B. Correlations of serum concentrations of 1,25-dihydroxyvitamin D, phosphorus and parathyroid hormone in tumoral calcinosis. J Clin Endocrinol Metab 1988:67:88.
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Smack DP, Norton SA, Fitzpatrick JE. Proposal for a pathogenesis-based classification of tumoral calcinosis. Int J Dermatol 1996;35:265.
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Bostrom B. Tumoral calcinosis in an infant. Am J Dis Child 1981;135:246.
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