Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current Issue
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
Images in Dermatology
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Media and news
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Images
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Reviewers 2022
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Snippets
Special Article
Specialty Interface
Studies
Study Letter
Study Letters
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Systematic Review and Meta-Analysis
Systematic Reviews and Meta-analyses
Systematic Reviews and Meta-analysis
Tables
Technology
Therapeutic Guideline-IADVL
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
Therapy Letters
View Point
Viewpoint
What’s new in Dermatology
Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current Issue
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
Images in Dermatology
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Media and news
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Images
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Reviewers 2022
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Snippets
Special Article
Specialty Interface
Studies
Study Letter
Study Letters
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Systematic Review and Meta-Analysis
Systematic Reviews and Meta-analyses
Systematic Reviews and Meta-analysis
Tables
Technology
Therapeutic Guideline-IADVL
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
Therapy Letters
View Point
Viewpoint
What’s new in Dermatology
View/Download PDF

Translate this page into:

Letter to the Editor
2017:83:3;367-369
doi: 10.4103/0378-6323.197391
PMID: 28071609

Verrucous eccrine angiomatous hamartoma

Prashant Verma1 , M Kaur2 , V Narula2 , V Ramesh1 , A Singh2 , AK Saxena1
1 Department of Dermatology, VMM College and Safdarjung Hospital, New Delhi, India
2 Department of Pathology, Indian Council of Medical Research, New Delhi, India

Corresponding Author:
Prashant Verma
9 State Bank Colony, G.T. Karnal Road, New Delhi - 110 009
India
drprashant_derma@yahoo.co.in
How to cite this article:
Verma P, Kaur M, Narula V, Ramesh V, Singh A, Saxena A K. Verrucous eccrine angiomatous hamartoma. Indian J Dermatol Venereol Leprol 2017;83:367-369
Copyright: (C)2017 Indian Journal of Dermatology, Venereology, and Leprology

Sir,

A 15-year-old girl presented with a lesion on her left thigh for the last 1 year. The lesion was associated with pain and hyperhidrosis which was often provoked by physical activity and emotional stress. Systemic examination was normal.

Cutaneous examination revealed a 9 cm × 6 cm, bluish-black, verrucous, firm plaque on the medial aspect of left thigh [Figure 1a]. The margins of the plaque were irregular. The lesion was warm and tender. On stroking, the surface of the plaque showed oozing beads of a shiny, transparent and colorless fluid [Figure 1b]. The starch-iodide test was positive.

Figure 1a: Bluish-black, verrucous plaque on the medial aspect of left thigh
Figure 1b: Beads of sweat on the surface of the plaque after stroking the lesion

Biopsy from the plaque revealed hyperkeratosis and marked acanthosis with elongated rete ridges and increased epidermal basal layer melanin. The underlying dermis showed dilated eccrine glands and admixed capillaries within and around these glands [Figure 2a]. In addition, tufts and lobules of vascular proliferation with prominent endothelial cells and slit-like capillaries were present in the dermis [Figure 2b]. Accordingly, a diagnosis of eccrine angiomatous hamartoma was rendered. Surgical excision was planned for the patient; however, she was lost to follow-up.

Figure 2a: Hyperkeratosis, marked acanthosis and increased epidermal basal layer melanin with dilated eccrine glands and admixed capillaries within and around these glands (H and E, ×100)
Figure 2b: Tufts and lobules of vascular proliferation with prominent endothelial cells and slit-like capillaries in the dermis (H and E, ×200)

The term eccrine angiomatous hamartoma was coined by Hyman et al. in the year 1968;[1] however, the clinical description was first put forward by Lotzbeck, in 1895 and the earlier name was sudoriparous angioma.[2] Eccrine angiomatous hamartoma is a rare, benign cutaneous proliferation of eccrine glands and thin-walled vascular channels. The lesions arise at birth or during childhood in 77% of cases.[3] Extremities, palms and soles in particular, are the usual sites affected.[4] Feet, face, neck and trunk may seldom be involved. Solitary, flesh-colored, blue-brown or reddish papules, plaques and nodules are characteristic. Occasionally, eccrine angiomatous hamartoma may manifest multiple lesions.[4] Pain and hyperhidrosis are reported in approximately 42% and 32%, respectively.[5] Interestingly, verrucous changes in the epidermis were noted in the present case which is a rare finding in eccrine angiomatous hamartoma.[6] Unencapsulated, dermal proliferation of mature-appearing eccrine secretory and ductal structures that are intimately associated with thin-walled angiomatous channels usually of a capillary nature but of variable size are the characteristic histopathological features of eccrine angiomatous hamartoma.[7] The exact etiology of this entity is not known. Some authors have proposed a pathophysiological model which considers it a biochemical fault in the interactions between differentiating epithelium and subjacent mesenchyme that gives rise to an abnormal proliferation of adnexal and vascular structures. It might be caused by abnormal induction of heterotypic dependency during organogenesis. Late-onset lesions are related to recurrent trauma.[8]

The differential diagnosis of eccrine angiomatous hamartoma includes tufted angioma, vascular malformations, macular telangiectatic mastocytosis, nevus flammeus, glomus tumor, smooth muscle hamartoma, congenital hamartoma of the eccrine sweat gland, eccrine nevus and single lesion of blue rubber bleb syndrome. These entities can be differentiated by histopathology. Of these, tufted angioma is a close differential as it may also manifest hyperhidrosis as seen in eccrine angiomatous hamartoma; however, histopathologically, tufted angioma shows a pandermal capillary proliferation with characteristic “cannon ball” appearance. Hypertrichosis, hyperhidrosis, pain or itching are valuable diagnostic clues. The natural history of eccrine angiomatous hamartoma is benign and typically slow-growing and hence, aggressive treatment is generally unwarranted. Simple excision is usually curative and is reserved for painful or cosmetically disfiguring lesions.[9] Deep excision with full-thickness grafting or amputation of a finger or toe may be required for symptom control in those with larger lesions on acral parts.[10] Botulinum toxin might be useful in hyperhidrotic cases.[11]

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

References
1.
Hyman AB, Harris H, Brownstein MH. Eccrine angiomatous hamartoma. N Y State J Med 1968;68:2803-6.
[Google Scholar]
2.
Tanaka M, Shimizu S, Miyakawa S. Hypertrophic eccrine glands in eccrine angiomatous hamartoma produce gross cystic disease fluid protein 15. Dermatology 2000;200:336-7.
[Google Scholar]
3.
Cebreiro C, Sánchez-Aguilar D, Gómez Centeno P, Fernández-Redondo V, Toribio J. Eccrine angiomatous hamartoma: Report of seven cases. Clin Exp Dermatol 1998;23:267-70.
[Google Scholar]
4.
Morrell DS, Ghali FE, Stahr BJ, McCauliffe DP. Eccrine angiomatous hamartoma: A report of symmetric and painful lesions of the wrists. Pediatr Dermatol 2001;18:117-9.
[Google Scholar]
5.
Martinelli PT, Tschen JA. Eccrine angiomatous hamartoma: A case report and review of the literature. Cutis 2003;71:449-55.
[Google Scholar]
6.
Galan A, McNiff JM. Eccrine angiomatous hamartoma with features resembling verrucous hemangioma. J Cutan Pathol 2007;34 Suppl 1:68-70.
[Google Scholar]
7.
Fathaddin AA, Alhumidi AA. Eccrine angiomatous hamartoma, with verrocous hemangioma-like features: A case report. Int J Health Sci (Qassim) 2013;7:103-6.
[Google Scholar]
8.
Zeller DJ, Goldman RL. Eccrine-pilar angiomatous hamartoma. Report of a unique case. Dermatologica 1971;143:100-4.
[Google Scholar]
9.
Lin YT, Chen CM, Yang CH, Chuang YH. Eccrine angiomatous hamartoma: A retrospective study of 15 cases. Chang Gung Med J 2012;35:167-77.
[Google Scholar]
10.
Gabrielsen TO, Elgjo K, Sommerschild H. Eccrine angiomatous hamartoma of the finger leading to amputation. Clin Exp Dermatol 1991;16:44-5.
[Google Scholar]
11.
Barco D, Baselga E, Alegre M, Curell R, Alomar A. Successful treatment of eccrine angiomatous hamartoma with botulinum toxin. Arch Dermatol 2009;145:241-3.
[Google Scholar]

Fulltext Views
3,712

PDF downloads
1,659
Show Sections