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2009:75:3;330-330
doi: 10.4103/0378-6323.51255
PMID: 19439907

Vesicular rash in a newborn

A Nogueira1 , C Lisboa2 , C Eloy3 , A Mota2 , F Azevedo1
1 Department of Dermatology, Venereology, Hospital S. Joo, EPE, Portugal
2 Department of Dermatology, Venereology, Hospital S. Joo, EPE; Faculty of Medicine, Oporto University, Portugal
3 Department of Pathology, Hospital S. Joo, EPE, Portugal

Correspondence Address:
A Nogueira
Department of Dermatology and Venereology, Hospital S. Joo, EPE, Alameda Prof. Hernni Monteiro, 4200 - 319 Porto
Portugal
How to cite this article:
Nogueira A, Lisboa C, Eloy C, Mota A, Azevedo F. Vesicular rash in a newborn. Indian J Dermatol Venereol Leprol 2009;75:330
Copyright: (C)2009 Indian Journal of Dermatology, Venereology, and Leprology

A full-term female newborn, with no history of consanguinity in the parents, presented at birth with generalized vesicles, pustules and blisters, appearing in crops, with preferential distribution on the limbs. She was otherwise well and was afebrile. A herpetic infection was considered, so after taking swabs, she was started on intravenous acyclovir. After an initial good response, the dermatosis worsened, assuming a roughly linear pattern [Figure - 1] and manifested with an impressive blood eosinophilia. The infectious cause was excluded (Tzanck test showed no giant cells, and there was a negative PCR for HSV, VZV and bacteriologic examination), and a skin biopsy was performed, which revealed spongiotic intraepidermal vesicles with a rich eosinophil infiltrate [Figure - 2]. Her mother recalled a history of a similar rash in her infancy, and displayed faint linear hypopigmented streaks on her calves, which were better observed with the Wood′s lamp [Figure - 3], conical incisor teeth and vertex alopecia.

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