Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current Issue
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
Images in Dermatology
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Media and news
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Images
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Reviewers 2022
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Snippets
Special Article
Specialty Interface
Studies
Study Letter
Study Letters
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Systematic Review and Meta-Analysis
Systematic Reviews and Meta-analyses
Systematic Reviews and Meta-analysis
Tables
Technology
Therapeutic Guideline-IADVL
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
Therapy Letters
View Point
Viewpoint
What’s new in Dermatology
Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
15th National Conference of the IAOMFP, Chennai, 2006
Abstract
Abstracts from current literature
Acne in India: Guidelines for management - IAA Consensus Document
Addendum
Announcement
Art & Psychiatry
Article
Articles
Association Activities
Association Notes
Award Article
Book Review
Brief Report
Case Analysis
Case Letter
Case Letters
Case Notes
Case Report
Case Reports
Clinical and Laboratory Investigations
Clinical Article
Clinical Studies
Clinical Study
Commentary
Conference Oration
Conference Summary
Continuing Medical Education
Correspondence
Corrigendum
Cosmetic Dermatology
Cosmetology
Current Best Evidence
Current Issue
Current View
Derma Quest
Dermato Surgery
Dermatopathology
Dermatosurgery Specials
Dispensing Pearl
Do you know?
Drug Dialogues
e-IJDVL
Editor Speaks
Editorial
Editorial Remarks
Editorial Report
Editorial Report - 2007
Editorial report for 2004-2005
Errata
Erratum
Focus
Fourth All India Conference Programme
From Our Book Shelf
From the Desk of Chief Editor
General
Get Set for Net
Get set for the net
Guest Article
Guest Editorial
History
How I Manage?
IADVL Announcement
IADVL Announcements
IJDVL Awards
IJDVL AWARDS 2015
IJDVL Awards 2018
IJDVL Awards 2019
IJDVL Awards 2020
IJDVL International Awards 2018
Images in Clinical Practice
Images in Dermatology
In Memorium
Inaugural Address
Index
Knowledge From World Contemporaries
Leprosy Section
Letter in Response to Previous Publication
Letter to Editor
Letter to the Editor
Letter to the Editor - Case Letter
Letter to the Editor - Letter in Response to Published Article
LETTER TO THE EDITOR - LETTERS IN RESPONSE TO PUBLISHED ARTICLES
Letter to the Editor - Observation Letter
Letter to the Editor - Study Letter
Letter to the Editor - Therapy Letter
Letter to the Editor: Articles in Response to Previously Published Articles
Letters in Response to Previous Publication
Letters to the Editor
Letters to the Editor - Letter in Response to Previously Published Articles
Letters to the Editor: Case Letters
Letters to the Editor: Letters in Response to Previously Published Articles
Media and news
Medicolegal Window
Messages
Miscellaneous Letter
Musings
Net Case
Net case report
Net Image
Net Images
Net Letter
Net Quiz
Net Study
New Preparations
News
News & Views
Obituary
Observation Letter
Observation Letters
Oration
Original Article
ORIGINAL CONTRIBUTION
Original Contributions
Pattern of Skin Diseases
Pearls
Pediatric Dermatology
Pediatric Rounds
Perspective
Presedential Address
Presidential Address
Presidents Remarks
Quiz
Recommendations
Regret
Report
Report of chief editor
Report of Hon : Treasurer IADVL
Report of Hon. General Secretary IADVL
Research Methdology
Research Methodology
Resident page
Resident's Page
Resident’s Page
Residents' Corner
Residents' Corner
Residents' Page
Retraction
Review
Review Article
Review Articles
Reviewers 2022
Revision Corner
Self Assessment Programme
SEMINAR
Seminar: Chronic Arsenicosis in India
Seminar: HIV Infection
Short Communication
Short Communications
Short Report
Snippets
Special Article
Specialty Interface
Studies
Study Letter
Study Letters
Supplement-Photoprotection
Supplement-Psoriasis
Symposium - Contact Dermatitis
Symposium - Lasers
Symposium - Pediatric Dermatoses
Symposium - Psoriasis
Symposium - Vesicobullous Disorders
SYMPOSIUM - VITILIGO
Symposium Aesthetic Surgery
Symposium Dermatopathology
Symposium-Hair Disorders
Symposium-Nails Part I
Symposium-Nails-Part II
Systematic Review and Meta-Analysis
Systematic Reviews and Meta-analyses
Systematic Reviews and Meta-analysis
Tables
Technology
Therapeutic Guideline-IADVL
Therapeutic Guidelines
Therapeutic Guidelines - IADVL
Therapeutics
Therapy
Therapy Letter
Therapy Letters
View Point
Viewpoint
What’s new in Dermatology
View/Download PDF

Translate this page into:

Net Letter
2015:81:2;224-224
doi: 10.4103/0378-6323.152325
PMID: 25751362

White fibrous papulosis of the neck

Rajat Kandhari1 , Sanjiv Kandhari1 , Sudhir Jain2
1 Consultant Dermatologist, Dr. Kandhari's Skin and Dental Clinic, New Delhi, India
2 Consultant Pathologist, OncQuest Laboratories, New Delhi, India

Correspondence Address:
Rajat Kandhari
11, Munirka Marg, Vasant Vihar, New Delhi - 110 057
India
How to cite this article:
Kandhari R, Kandhari S, Jain S. White fibrous papulosis of the neck. Indian J Dermatol Venereol Leprol 2015;81:224
Copyright: (C)2015 Indian Journal of Dermatology, Venereology, and Leprology

Sir,

White fibrous papulosis of the neck (WFPN) is an under-reported entity. It is characterized by multiple, 2-3 mm sized, discrete, asymptomatic, pale- to skin-colored, non-follicular, firm papular lesions present predominantly on the neck in elderly individuals. The racial prevalence is unclear although it has been reported from various parts of the world, with no sexual predilection. [1]

A 73-year-old woman presented with mildly pruritic, papular lesions on her neck for 1 year. She had no history of prolonged sun exposure and denied rubbing or scratching the affected areas. Her other illnesses included hypertension, paroxysmal atrial fibrillation, chronic kidney disease and hyperuricemia for which she was being treated with doresemide, clopidogrel and aspirin combination, and febuxostat. There was no history suggestive of vascular, gastrointestinal or ocular disorders and no history of similar lesions in other family members. Dermatological examination revealed multiple, discrete, non-confluent, pale- to skin-colored papular lesions predominantly on the lateral side of her neck extending to the nape of the neck. The lesions were firm, non-follicular, and varied in size from 2-4 mm and had progressively increased in number slowly over the past 1 year [Figure - 1]. Examination of the cardiovascular, respiratory and gastrointestinal systems revealed no abnormalities and her peripheral pulses were normal. Examination of the fundus did not demonstrate angioid streaks. Skin biopsy from the papules revealed mild orthokeratotic hyperkeratosis and haphazardly arranged bundles of collagen fibers in the reticular and deep dermis. The elastic fibers were normal but slightly reduced in number [Figure - 2], [Figure - 3], [Figure - 4]. In view of the normal elastic fibers seen on histology, characteristic clinical features and lack of systemic signs a diagnosis of white fibrous papulosis of neck was made. The patient was counseled regarding the condition and no treatment was given. There had been no change in the lesions on follow up 6 months later.

Figure 1: Multiple, discrete, non-follicular, firm papules on the lateral aspect of the neck
Figure 2: Haphazardly arranged bundles of collagen fibers in the reticular and deep dermis. (H and E, ×100)
Figure 3: Higher magnification with bundles of collagen with elastic fibers (E) (H and E, ×400)
Figure 4: Elastic fibers in black and collagen fibers seen in red (Verhoeff-VanGieson, ×400)

White fibrous papulosis of neck was described in 1985 by Shimizu and Nishikawa. [2] Clinically, it is characterized by multiple, usually asymptomatic, non-confluent, non-pedunculated, and non-follicular, firm papules occurring on the posterior or lateral sides of the neck. They may vary in number and size and may rarely involve other sites such as the trunk and upper arms. [3] No associated systemic co-morbidities have been reported with this condition and the occurrence of paroxysmal atrial fibrillation and chronic kidney disease in our patient may be purely coincidental. Whether systemic conditions or drug intake have a role in triggering the disease needs further elucidation.

Histologically, white fibrous papulosis of neck is characterized by slight, focal increase and thickening of collagen fibers in the papillary dermis. accompanied by normal to decreased elastic fibers. [4] It has clinical and histological similarities with dermatoses such as pseudoxanthoma elasticum-like papillary dermal elastosis (PXE-PDE) and mid-dermal elastosis (MDE).These are distinguishable on the basis of subtle signs[Table - 1]. In circumstances where there is sharing of clinical and histopathological features, the term "fibroelastolytic papules of the neck" (FEPN) has been used. [5],[6] Ultrastructurally, no abnormalities of the elastic fibers are observed and collagen fibrils seem tightly compacted with a slight increase in their diameter. These changes are considered to be non-specific features of papillary dermal fibrosis, associated with structural collagen alterations and/or abnormalities of the extracellular microenvironment. [7],[8]

Table 1: Differential diagnosis of white fibrous papulosis of neck

Treatment of this condition is unsatisfactory and not necessary considering the benign nature of the condition. Natural regression has not been reported.

References
1.
Kim HS, Yu DS, Kim JW. White fibrous papulosis of the neck. J Eur Acad Dermatol Venereol 2007;21:419-20.
[Google Scholar]
2.
Shimizu H, Nishigawa T, Kimura S. White fibrous papulosis of the neck; review of our 16 cases. Nihon Hifuka Gakkai Zasshi 1985;95:1077-84.
[Google Scholar]
3.
Mitoma C, Takahara M, Takeshita T, Kiryu H, Moroi Y, Furue M White fibrous papulosis on the trunk and upper arms. Int J Dermatol 2013;52:337-8.
[Google Scholar]
4.
Chan JY, Chu CY, Hsiao CH, Chen JS. Fibroelastolytic patterns of intrinsic skin aging: Pseudoxanthoma elasticum - like papillary dermal elastolysis and white fibrous papulosis of the neck. Dermatol Sin 2003;21:402-7.
[Google Scholar]
5.
Rongioletti F, Izakovic J, Romanelli P, Lanuti E, Miteva M. Pseudoxanthoma elasticum-like papillary dermal elastolysis: A large case series with clinicopathological correlation. J Am Acad 2012;67:128-35.
[Google Scholar]
6.
Jagdeo J, Ng C, Ronchetti IP, Wilkel C, Bercovitch L, Robinson-Bostom L. Fibroelastolytic papulosis. J Am Acad Dermatol 2004;51:958-64.
[Google Scholar]
7.
Zanca A, Contri MB, Carnevali C, Bertazzoni MG. White fibrous papulosis of the neck. Int J Dermatol 1996;35:720-2.
[Google Scholar]
8.
Rongioletti F, Rebora A. Pseudoxanthoma elasticum like papillary dermal elastolysis. J Am Acad Dermatol 1992;26:648-50.
[Google Scholar]

Fulltext Views
4,812

PDF downloads
2,183
Show Sections