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Short Communication
PMID: 20948052
Paucity of immune complexes in skin lesions of lichen planus
Sandipan Dhar1 , Amrinder J Kanwar1 , Goutam Dawn1 , Shobha Sehgal2
1 Department of Dermatology, Post-graduate Institute of Medical Education and Research, Chandigarh-160 012, India
2 Department of Venereology & Leprology and Immunopathology, Post-graduate Institute of Medical Education and Research, Chandigarh-160 012, India
Correspondence Address:
Shobha Sehgal
Department of Venereology & Leprology and Immunopathology, Post-graduate Institute of Medical Education and Research, Chandigarh-160 012
India
2 Department of Venereology & Leprology and Immunopathology, Post-graduate Institute of Medical Education and Research, Chandigarh-160 012, India
Correspondence Address:
Shobha Sehgal
Department of Venereology & Leprology and Immunopathology, Post-graduate Institute of Medical Education and Research, Chandigarh-160 012
India
| How to cite this article: Dhar S, Kanwar AJ, Dawn G, Sehgal S. Paucity of immune complexes in skin lesions of lichen planus. Indian J Dermatol Venereol Leprol 1995;61:21-25 |
Copyright: (C)1995 Indian Journal of Dermatology, Venereology, and Leprology
Abstract
The significance of deposition, of immunoglobulin and/or complements at the dermoepidermal junction (DEJ) and civatte bodies in skin lesions of 15 histopathologically confirmed cases of lichen planus (LP) was evaluated. Civatte boides were seen in 6 (40%) patients while in 9 (60%) these were absent. IgM, IgG, IgA and C3 were seen within civatte bodies in 6,3, 2 and 3 specimens respectively in various combinations. LP lesions of a shorter duration (one year or less) had cjvatte bodies while these were absent in those with disease of a longer duration (more than 1 year). Immune complex deposition was seen in only 2 patients. It is concluded that civatte bodies are of diagnostic importance in lichen planus lesions of a short duration only and immune complexes do not seem to play a significant role in its pathogenesis.
Keywords: Lichen planus, Civatte body, Immune complex, Complement, Dermoepidermal junction
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